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BenefitsofHumanGenomeProject

Rapidprogressingenomescienceandaglimpseintoitspotentialapplicationshavespurredobservers topredictthatbiologywillbetheforemostscienceofthe21stcentury.Technologyandresources generatedbytheHumanGenomeProjectandothergenomicsresearcharealreadyhavingamajor impactonresearchacrossthelifesciences.Thepotentialforcommercialdevelopmentofgenomics researchpresentsU.S.industrywithawealthofopportunities,andsalesofDNAbasedproductsand technologiesinthebiotechnologyindustryareprojectedtoexceed$45billionby2009(Consulting ResourcesCorporationNewsletter,Spring1999). Somecurrentandpotentialapplicationsofgenomeresearchincludemolecularmedicine,microbial genomics,riskassessment,bioarchaeology,anthropology,evolution,humanmigration,DNAforensics (identification),agriculture,livestockbreeding,andbioprocessing. TechnologyandresourcespromotedbytheHumanGenomeProjecthaveprofoundimpactson biomedicalresearchespeciallyinclinicalmedicine.Increasinglydetailedgenomemapshaveaided researchersseekinggenesassociatedwithdozensofgeneticconditions,includingmyotonicdystrophy, fragileXsyndrome,neurofibromatosistypes1and2,inheritedcoloncancer,Alzheimer'sdisease,and familialbreastcancer.Thiswillprovokeaneweraofmolecularmedicinecharacterizedlessbytreating symptomsandmorebylookingtothemostfundamentalcausesofdisease.Rapidandmorespecific diagnostictestswillmakepossibleearliertreatmentofcountlessmaladies.Medicalresearchersalso willbeabletodevisenoveltherapeuticregimensbasedonnewclassesofdrugs,immunotherapy techniques,avoidanceofenvironmentalconditionsthatmaytriggerdisease,andpossibleaugmentation orevenreplacementofdefectivegenesthroughgenetherapy.Besides,researchonhumanevolution becomeeasierandclearerwhenafullanddetailedgenomemaphavebeencreated. Understandingthehumangenomewillhaveanenormousimpactontheabilitytoassessrisksposedto individualsbyexposuretotoxicagents.Scientistsknowthatgeneticdifferencesmakesomepeople moresusceptibleandothersmoreresistanttosuchagents.HumanGenomeProjecttechnologiesalso canhelptoassesshealthdamageandriskscausedbyradiationexposure,includinglowdoseexposures. Furthermore,damageandriskscausedbyexposuretomutagenicchemicalsandcancercausingtoxins alsocanbeassessed.Consequently,thelikelihoodofheritablemutationscanbereduced. Otherbenefitsgainedfromthehumangenomeprojecttowardsimprovementofhumanlifeinclude: identifypotentialsuspectswhoseDNAmaymatchevidenceleftatcrimescenes establishpaternityandotherfamilyrelationships detectbacteriaandotherorganismsthatmaypolluteair,water,soil,andfood matchorgandonorswithrecipientsintransplantprograms determinepedigreeforseedorlivestockbreeds understandingdiseasevulnerabilitiesandrevealingdrugtargets environmentalmonitoringtodetectpollutants

protectionfrombiologicalandchemicalwarfare

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