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IMMUNOCAL ®

Medical Breakthrough

Immunotec Research Ltd. announces the release of a powerful and unique nutraceutical. IMMUNOCAL®, a 100% natural bonded
cysteine dietary supplement with superior nutritional value, is formulated to contain significantly high amounts of the rare precursors
(building blocks) of GLUTATHIONE (GSH). GSH is the cells' own natural and most vital antioxidant, and detoxifier. GSH serves to
reinforce both healthy and deficient immune systems. Immunocal® is essentially lactose-, and fat-free (under 1%), and has no
known side effects.

It was the original discovery of the importance of GSH (Glutathione) in boosting the immune system that led to the development of
IMMUNOCAL®. As a result of many years of research which began in the late 1970's, Dr. Gustavo Bounous (world expert on GSH)
and a team of McGill University physicians and scientists demonstrated that by using a whey protein isolate in the diet of
experimental animals, the animals' life span was increased by as much as 30% to 50%. This effect was a result of immune-function
enhancement which occurred in a variety of ways, including a heightened resistance to infection, a lowered incidence of cancer,
and a greater immune response when challenged with bacteria, viruses, or foreign antigens.

Glutathione is a substance made up of three amino acids: glutamic acid, glycine, and most importantly, cysteine which gives the
molecule its biological activity. GSH is found in almost all human cells. GSH cannot be transported into cells; it must be
manufactured within the cells. The only way to do this is by supplying the appropriate building blocks (precursors), which are the
active ingredients in IMMUNOCAL®.
In the course of normal cell metabolism, by-products called 'oxyradicals', or 'free radicals', are created, which, unless immediately
neutralized, can lead to poor health. High GSH levels are the key to this protective response. Other antioxidants such as Vitamin C
and E depend on GSH for their own function.
GSH is concentrated in the liver, where it functions as a key detoxifying agent. Multiple toxins, pollutants and carcinogens are
eliminated from our bodies via GSH enzymatic pathways.
Our immune system depends on the proper response to foreign challenges like bacteria, viruses and parasites, and abnormal cells.
GSH plays a crucial role in the function and multiplication of our lymphocytes to combat these organisms.
IMMUNOCAL® is the only natural product patented to safely raise and sustain GSH. Other methods to raise intracellular
glutathione in the past have included N-acetylcysteine (NAC) as well as other drugs. However, these have very short-lived effects.
Actual ingestion of glutathione, although possible, has clearly been shown to be ineffective, as it is almost completely digested and
excreted intestinally. Dr. James Balch stated in his book The Super Antioxidants, "people have thrown money away taking
glutathione supplements that their body cannot use." The isolated amino acid cysteine, when taken by itself, is poorly absorbed and
potentially toxic. Other forms of whey protein have variable or negligible bioavailability of GSH precursors and are easily denatured
(damaged) in the manufacturing and handling process, leading to low bioactivity.*

*For more information, please see "GSH, Your Body's Most Powerful Healing Agent" or "Breakthrough in Cell Defense" available at
book stores or through the return address on this pamphlet. These two books contain exhaustive references.
IMMUNOCAL®/HMS 90® is a patented, highly concentrated protein that in nature is most similar to mother's milk. In Canada it is
called HMS 90® to denote Humanized milk Serum. It shares with mother's milk many immune promoting benefits.
High in rare cysteine-delivering properties, it is prepared using a propriety process leading to a non-denatured 90% protein powder,
preserving the original bioactivity of the thermolabile components. In other words, this guarantees the highest level of GSH-

To get more information p.416.769.2971, immunotec@3web.com or www.immunotec.com/maktek

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promoting activity available. It is the only concentrate patented for immuno-optimizing and glutathione-enhancing effects.
Although marketed in Europe, North Africa, and the Far East by pharmaceutical firms, this all-natural product can be purchased
without prescription in North America. It is listed in the Physicians Desk Reference Drug catalog, and the Pharmacist's Red Book of
prescription products, and it meets criteria for reimbursement for medicare/medicaid.

Clinical trials in the USA, Canada, and Japan point to the benefits of IMMUNICAL®. A series of case reports on the use of
IMMUNOCAL® in urogenital cancer was published in the journal of Anti-Cancer Research (Anti-Cancer Research 2000 Nov-Dec;
20(6c):4785-92.) The data corroborates the anti-cancer, anti-tumor effect on cancer seen in earlier animal studies and small human
studies. In another study by Ammunomed accepted for presentation at the 2002 Int. meeting of the institute of Human Virology,
IMMUNOCAL® alleviated side effects of HAART treatment in AIDS patients, and contributed to weight gain and marked
improvement. The Nova Scotia Cancer Center (Dalhousie University) has published on IMMUNOCAL® and metastatic cancer and
has undertaken a phase III trial on breast cancer. Japanese studies have shown its positive effects on hepatitis B. IMMUNOCAL®
has been demonstrated to combat major bacterial and viral infections. Also, a phase II trial on Cystic Fibrosis is underway in
Montreal. Immunotec Research Ltd. has established a fund to promote further studies.

IMMUNE SYTEM
Clinical studies have proven that immune depressed individuals have lower GSH concentrations. Healthy people also experience a
drop in GSH levels when fighting disease. Lymphocytes, cells vital for your immune response, depend on GSH for their proper
function and replication.
IMMUNOLOGY 61:503-508, 1987

ANTIOXIDANT FUNCTIONS
Antioxidants are well-documented to play vital roles in health maintenance and disease prevention. GSH is the cell's own major
antioxidant. It recycles other antioxidants, such as vitamins C and E.
BIOCHEMICAL PHARMACOLOGY 47:2113-2123, 1994

TOXINS, POLLUTION, RADIATION

GSH detoxifies pollutants, carcinogens, and poisons, including many found in fuel exhaust and cigarette smoke. It retards damage
from radiation such as that caused by the increased losses of the ozone layer. It reduces neurotoxicity, an underestimated hazard.
ANNUAL REVIEWS OF BIOCHEMISTRY 52:711-760, 1983

AGING PROCESS
By the age of 40 there is a precipitous drop in GSH levels. Lower glutathione levels are evident in many diseases associated with
aging including cataracts, Alzheimer's disease, Parkinson's, arteriosclerosis, etc.
JOURNAL OF CLINICAL EPIDEMIOLOGY 47:1021-26, 1994

HEALTHY INDIVIDUALS & ATHLETES

Intense muscular activity generates oxyradicals leading to muscle fatigue and poorer performance. GSH neautralizes exercised-
induced oxyradicals. A recent study with healthy individuals showed a 13% muscular performance increase when Immunocal was
used for 90 days.
AMERICAN J. RESP.CRIT. CARE MED. 159:A719, 1999

CARDIOVASCULAR APPLICATIONS
GSH has been shown to prevent atheriosclerosis and even reverse it. GSH retards the oxidation of cholesterol and is greatly

To get more information p.416.769.2971, immunotec@3web.com or www.immunotec.com/maktek

IMMUNO-PRESS Page 3 of 3 FOR IMMEDIATE REVIEW
beneficial in preventing heart disease, strokes, and reperfusion injury.
NUTRITION REVIEWS 54:1-30, 1996

INFECTIOUS & AUTOIMMUNE DISEASES

GSH supports and rebalances the body's anti-infective defenses. This impacts bacterial infections, autoimmune dysfunctions,
Chronic Fatigue Syndrome, herpes, hepatitis, etc.
IMMUNOLOGY 61: 503-508, 1987

CANCER
GSH eliminates many carcinogens and also maintains immune function. IMMUNOCAL® has Method-of-Use Patents for preventing
and treating cancer. It can reduce side effects from some cancer therapies.
CANCER LETTERS 57:91-94, 1991

NEUROLOGICAL DISEASE
Low GSH levels is a common denominator in neurodegenerative diseases such as Multiple Sclerosis (MS), "Lou Gehrig's Disease"
(ALS), Alzheimer's, Parkinson's and others.
THE LANCET 344:796-798, 1994

PULMONARY DISORDERS
Chronic Bronchitis, Cystic Fibrosis, and Asthma have been clinically shown to impact and lower glutathione levels. Repleting
glutathione shows clinical benefits.
AMERICAN J. MED. SCI. 307:119-127, 1994

AIDS
IMMUNOCAL® HAS A Method-of-Use Patent for HIV/AIDS treatment. Low Glutathione levels correlate with poor survival in AIDS
victims. Scientific studies demonstrate the benefits of enhancing GSH in AIDS patients.
PROC. NATIONALACAD. SCIENCE USA94:1967-72, 1997

Instructions for use: One pouch (10g) daily; mix and shake vigorously in a closed container with 2 oz. of your favorite beverage,
preferable nonacidic, at room temperature or cooler. Allow 2 minutes to dissolve, then add 4 oz. more liquid, shake and drink.
Immunocal can also be added to milk, cereals, apple sauce or other foods, as part of a healthy dietary regimen.

To get more information p.416.769.2971, immunotec@3web.com or www.immunotec.com/maktek