CONFIDENTIAL

Æsis Research Group

Ogan Gurel, MD MPHIL
Chairman & Chief Executive

15 August 2007

Jonathan Metzl
Assistant Director
Studley
191 N Wacker Dr Ste 2700
Chicago, IL 60606-1881

Dear Jonathan,

Thank you again for the NeoPharm RFP which we received last week. We are pleased to provide you with
this attached proposal for NeoPharm to occupy mixed office and laboratory space in this world-class facility.
As discussed, we are able to deliver approximately 12,445 for occupancy commencing January 1st, 2008 or
shortly thereafter.

As you know the Excellerant project we have been developing at the Mundelein site has generated
considerable interest among government, business and academic leaders in the greater Chicago area and
indeed nationally. Our mandate is to create a nationally recognized life sciences accelerator which combines
an extremely high-end research facility, with an experienced, full-service in-house CRO, and top-notch shared
business services support all in a dynamic environment supporting rapid and efficient development among
startup and development-stage life sciences companies.

The economics of any deal is important but in addition, we seek tenants who we feel will be a great fit for the
facility. Indeed, our preliminary assessment is that NeoPharm would be an ideal anchor tenant for what will
be a very high profile and prominent facility with exposure nationwide to the academic, biopharmaceutical,
government and investment communities.

This proposal is roughly split into three parts.

1. A description of the Excellerant Life Sciences Accelerator and the facility

2. Specific discussion of the proposed space plans and value proposition for NeoPharm

3. The specifics (in bullet-form) of our proposal including proposed lease terms, space
allocation, etc.

Please note that as stipulated in your RFP, final terms will depend, of course, on execution of a negotiated
lease. We look forward hearing from you and are eager to answer any questions you may have going forward.

We are very excited about working with NeoPharm and, of course, with Studley.

Yours sincerely,

PO Box 578025 Chicago IL 60657 | Tel (312) 246- 5160| Fax (773) 409- 5897 | www.aesisgroup.com
Building value for healthcare and life sciences companies and investment firms
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About The Excellerant Life Sciences Accelerator

Excellerant aims to be the world’s leading Life Sciences Accelerator whose mission is to help
bridge the Innovation Gap and bring life-saving life sciences technologies faster to market.
The Excellerant Life Sciences Accelerator combines three basic elements to create a truly unique
environment for development-stage life sciences companies to grow and thrive. These include:

1. Excellerant Real Estate – a world-class laboratory and associated office space facility with
virtually no bounds on the range and scope of experiments that can be performed,

2. Excellerant Research - a full-service contract research organization (CRO)

3. Excellerant Management - a well-connected, committed management company that

assists it’s tenant companies – to the extent necessary – with providing shared business
services, a stimulating academic environment and access to other business and investment
resources.

Obviously, for the purposes of this RFP the main focus is on the building.

This single-story building is approximately 70,000 sf with 63,400 under heat and air and the rest
closed docks. Ample employee and visitor parking spaces are also included and the total land space
(included) is 130,680 sf. A satellite photo of the building and floor plan are shown below.

The building and accompanying infrastructure is extensively built out for chemical, biological
microbiological and/or pharmaceutical work with 35 separate air handling systems, over 40 separate
labs, heavy duty ventilation, heating, electrical, back-up generators, clean rooms (class 100, 1000 and
10,000). The building was also structurally engineered for a possible 2 nd floor expansion. Extensive
conference room space, office space, educational spaces, etc. are also included. The building is
located in Mundelein, Illinois with good access to transportation (two miles west of IL-60) and
O’Hare International Airport.

PO Box 578025 Chicago IL 60657 | Tel (312) 246- 5160| Fax (773) 409- 5897 | www.aesisgroup.com
Building value for healthcare and life sciences companies and investment firms
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Æsis Research Group

Summary of Building Research Capabilities

 70,000 Sq. Ft. Facility with 40+ Laboratories and 32 separate air handling facilities
 High-end biochemistry, molecular biology, microbiology equipment
 Outstanding educational and training facilities
 While much of these capabilities depend upon specialized equipment – all of which is available for use
either through Excellerant Research or rental use of such equipment as necessary.

With multiple research, development and industry capabilities such as:

 Nanotechnology  Regenerative Medicine / Stem Cell

o 100,000 rated cleanrooms Research
o Particulate Analysis o Tissue culture facilities

 Forensic science  Chemistry & Biochemistry

o Investigation of Criminal o Water Testing
Defendants o Chemical Analysis including D-
o Sex offender and Violent Felon value/z-value Analysis
Database DNA profiling o Stability studies
o Unknown Soldier Identification o Analytical and Protein chemistry
o Forensic DNA Analysis o USP Monograph testing
o Missing Person Identification  Microbiology
o Mass Accident or Terrorist Attack o Sterile Cleanrooms For Sensitive
Victim Identification Analyses
o Paternity Testing o Vaccine development
 Molecular Biology o Endotoxin Identification
o Genetic Profiling o Microbial Identification
o Complete DNA analysis o Sterility testing with multiple
o Ribotyping sterility suites
o DNA sequencing o Bacterial and Fungal Taxonomy
o High capacity incubators
 Manufacturing support (GMP)
o D-value/Z-value Analyses
o Closure/Package Integrity
o Viable/Non-viable Environmental
Monitoring
o Analytical Method
Development/Validation

PO Box 578025 Chicago, IL 60657-8025 | Tel (312) 246-5160 | Fax (773) 409-5897 | gurel@aesisgroup.com P. 3
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Overall Space Plan for the Facility

Square Feet
Total 70,000
Covered dock 6,600
Interior Space 63,400
Common Areas 10,000
Excellerant Mgmt Office 2,000
Reserved 5,000
CRO 8,796

Total rentable space is approximately 37,600 sf of which half is roughly office space and the other
half high-end laboratory space.

All spaces come fully furnished with high-end office furniture and top-of-the line laboratory fixtures.
The estimated replacement value of the laboratory fixtures alone (table tops, etc.) is $789,000.

NeoPharm proposed space

PO Box 578025 Chicago IL 60657 | Tel (312) 246- 5160| Fax (773) 409- 5897 | www.aesisgroup.com
Building value for healthcare and life sciences companies and investment firms
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Æsis Research Group
Common spaces
A full range of common spaces are included include

 small and large conference rooms (in addition to whatever the tenant builds out in their
own space)
 dining facility (900 sf)
 fully equipped exercise facility (800 sf)
 trade show staging room and/or large conference space (3,400 sf)
 covered dock (6,600) and adjoining receiving warehouse space
 Shared use (on a rental basis) large incubator rooms

All common areas are included in the gross rental fee and are available on a “sign-up” basis with the
management company although an anchor tenant such as NeoPharm can receive priority scheduling
for such space. Large walk-in incubator use would constitute an additional charge as with all other
high-end equipment rentals. The facility includes an onsite cooled server room which has high-end
T1 access and can accommodate additional equipment per tenant needs.

Equipment Rental
Below is a partial list of equipment available for rental use by tenants per availability.
Equipement ETO sterilizer Non-Porous Package Tester Stop Watch
12-Channel Auto Pipette Filler Sealer - Vitek Vacuum Gauge Storage Unit
3M aHest 290-Auto Reader Flow Meter Oscilloscope Syringe pump
Absorbance Detector Fluke DMM Oven Dry Heat Tachometer-Shimpa
Agilen 1100 Series Freezer Particle Counter teledyne gurley densitoner
Air compressor Gas Chromatograph Pipetaide Temperature Recorder
Air Dryer Genetic Analyzer Pipette Auto Tension Compression Tester
Air Sampler Guided Wave Pipetteman Thermal Cycler
Alpha Unit Block Gvam Stainer Plate Washer Thermal Impulse Heat sealing
Amtrol Pressuriser Heat block Polarimeter Thermix Stirring Hot Plate
Analect FTIR Spectrometer Hood 6' Portable Kaye Validator Thermolyne Mixer
Aquabath Hood Overhead Hepa Precision DC source Thermometer
Auto Dispenser Hot Air Gun Pressure Gauge Thermometer hand held
Autoclave Hot Plate Promac Calibrator Timer
Balance Hot Plate Stirrer Protean IEF Cell Titrator
Bier Unit HPLC Mainframe Pulse UV Turbo Guage
Biological Cabinet HTR-400 Pump Ultra Cleaner
Biorad ICAL Module SIM Block Refrigerator/Cooler UltraPlow Bath
Bioreactor ICE Point Reference Kaye RH Generator Ultrasonic Cleaner
Biotech International B. Braun Impulse foot pedal Sealer Ribo Printer UV germicidal chamber
Caliper In Line Heater Rocker UV Light
Centrifuge Incubator Rotator UV-Visible Spectrophotometer
Chart Recorder Intact packaging chamber Sanyo CO2 Incubatoer Vacuuum Oven
Chatillan TCP200 integrity chamber pH temp Scale Vacuum pump
Clamp Meter meter Scan RDI Chemuner Validator 2000
CO2 Incubator IRTD Scientemp Freezer Variac
Cold Room Freezer Isolator Scope VHP BIER Unit prototype
Colony Counter Joslyn Steam Bier Sensor Input Module VhyPhR
Darkfield Colony Counter Kay LTR 40/140 Shaker Volometer Alnor
DC Power Supply LabLine CO2 Incubator SIM Voltmeter
DI Water System Lindberg Blue SIM Block Vortexer
Digital Scale G42820 LTR140 Sonifier VWR Anaerobic Incubator
Dish Washer LTR-4/140 Spectra Max WaterBath
Dry Oven Manometer Spectrometer Watlow Infrared
Dual Absorbance Detector Mass Flow Controller Spectrophotometer Fermentor
Easy Pure Water Barnstead Mechanical Shaker Stage Micrometer YSI-BIO-ANALYZER
Eco-Fuge Mettler AE100 Steam Bath SHIMADZU TOC
Envi-chamber Microbial Container Steritest Integral
ETO Abator Microscope Stirrer
ETO bier Unit Napco Incubator Stirring Hot Plate

PO Box 578025 Chicago, IL 60657-8025 | Tel (312) 246-5160 | Fax (773) 409-5897 | gurel@aesisgroup.com P. 5
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Overall Proposed Space Plan for NeoPharm

Based on prior visits by the NeoPharm team and the RFP presented by Studley, a specific section of
the facility has been identified that optimally fit’s NeoPharm’s current needs. Obviously, since
nearly 38,000 sf is available, there is room for ample expansion. Even if the facility is fully occupied
by incubator (startup) tenants, these leases are typically short at 6 months to one year so that will be
ample opportunity to accommodate growth even in the context of full occupancy.

“F” section (“sun-room”) + private office entry

APPROXIMATE SF

F space total 8,785 Office Entry 3,660

Office Entry 3,660 F Mid 1,976
Total 12,445 F East 2,562
Total 8,199

Lab Total 4,246

The advantages of this space are considerable. They include:

 A single, contiguous space
 However, there is a rough separation into an executive area and a mixed lab/office area
 a private entrance (upper right hand – SE - corner)
 optional other entrance at the SW corner (currently an emergency exit)
 ability to quickly access common area spaces (also can be locked/coded)
 Private restroom facilities (on the west side)
 A range of office, laboratory and cubicle options. Cubicles would be in the center area
surround by lab space
 We can work with NeoPharm to ensure that surrounding areas are rent to other tenants last
so that easy, contiguous expansion may be possible.

PO Box 578025 Chicago, IL 60657-8025 | Tel (312) 246-5160 | Fax (773) 409-5897 | gurel@aesisgroup.com P. 6
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Overall Value Proposition for NeoPharm

 Contiguous space, set off from other spaces in the building

 Private entrance

 Private restroom facilities

 High-end facility with virtually unlimited experimental potential

 Access to high-end equipment on a rental basis per availability

 Dynamic, vibrant community planned

 Potential in-licensing opportunities from incubator co-tenants

 Outstanding common room facilities for large conferences, trade show set up

 Employee exercise facility

 As an anchor tenant an opportunity to gain significant exposure among industry and

institutional investors as the overall Excellerant project is promoted

 Significant (and potentially contiguous) expansion availability

 Fully furnished

 Fully available January 1st, 2008

PO Box 578025 Chicago, IL 60657-8025 | Tel (312) 246-5160 | Fax (773) 409-5897 | gurel@aesisgroup.com P. 7
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Æsis Research Group

Proposal

Based on the “F” section above + private executive office entry “tail”

Approx sq ft
Office 8,199
Lab 4,246
Total 12,445

Per sf/year Monthly

Net Rent $22.12 $22,940
Operating Expenses (*) $12.13 $12,580
Taxes $0.94 $975
Gross Rent $35.19 $36,495

(*) includes

 Common area usage (per availability) including conference rooms, loading dock, trade show
staging area, exercise facility
 Telecommunications and internet connectivity
 All HVAC costs prorated to tenant space
 All insurance, maintenance, landscaping, upkeep and other costs
 Parking (exceeds proposal request)
 Fully furnished
 Tenant specific backup generator

Other terms

 5-year lease, renewable

 Security deposit to be determined based on review of financials
 Rent to increase 2% per year with increase commencing on January 1st of each calendar year.
 Lease can commence as early as January 1st , 2008 but no later than March 1st, 2008
 If commencing January 1st , 2008, then the first two months are charged at ½ gross rent
 Rent converts to full gross lease on March 1st , 2008 as quoted.

As per the RFP request, any terms and conditions referenced above shall not be binding upon
Landlord or Tenant until a lease agreement and related documents have been fully executed by both
Landlord and Tenant. Until such time neither party shall be contractually obligated to the other in
any way.

This RFP is valid through August 31 st, 2007. Both Aesis, Excellerant and Studley should be keep
this proposal except to the extent required to serve NeoPharm and NeoPharm only.

PO Box 578025 Chicago, IL 60657-8025 | Tel (312) 246-5160 | Fax (773) 409-5897 | gurel@aesisgroup.com P. 8
Providing investment intelligence and research services to healthcare investment decision makers