SCHB Joseph Sabol

Monday, March 26, 2012

Oral Session Exponential Technologies: Disruptive Influences and Rapid Advancements in Chemistry - PM Session

Location:

San Diego Convention Center Monday March 26, 2012

Room: Room 26B Cosponsored by: Organizers: Presiders: Duration: Pres Time 1:30 pm Introductory Remarks CEPA, COMSCI

Lisa Butters Lisa Butters 1:30 pm - 4:20 pm Pub # Presentation Title

1:35 pm

Digital biology: Life under Moore's Law Raymond McCauley, Genomera, Inc., Mountain View, CA 94041, United States The ability to read DNA is in the midst of an unprecedented exponential change. The Human Genome Project took about $300 million and 11 years to complete, we now do for under $5000 in a week, and there's no end in sight. What are the practical applications of this technology? What are the technical and economic trends driving this revolution? How can small, agile companies ride along? And where are we going next? 2:05 pm 7

Broadband magnetic signatures of solvated chemistries Bennett M. Butters, Nativis, Inc., United States A low temperature SQUID (super conducting quantum interference device) based approach to broadband molecular interrogation is discussed with an emphasis on the technical basis for detection, signal analysis, and the usefulness of acquired data. Also, presented are the analytical results of selected materials and the implications to biochemistry. 2:35 pm 8

Nanostructured materials for large and small molecule selectivity Robert Meagley, ONE Nanotechnologies, LLC, Berkeley, CA 94710, United States We describe work ongoing at ONE Nanotechnologies, LLC to create and refine chemoselective films for application as recognition elements in several sensor platforms. Organic materials and nanocomposites have been developed that allow gas phase and liquid phase detection of explosives and chemical agents. Very high surface area interfaces are achieved through processes suitable for high volume manufacture. Novel strategies enabling high molecular weight precursors to be used in a plasma enhanced deposition mode will be shown. Highly structured surfaces shown to have significant capability to recognize individual proteins from mixtures will be presented and implications for advanced biomarker sensing will be discussed. The thrust of this work illustrates the value of an interdisciplinary approach to advanced material design and integration in devices. 3:05 pm Intermission

3:15 pm

Sequencing DNA by looking at it: Seeing chemistry with atoms rather than ensembles of atoms (or, "Why I left a full professorship to join a startup") Andrew Bleloch, Halcyon Molecular, Redwood City, CA 94063, United States The development of highly multiplexed sequencing reactions via clonal oligonucleotide clusters has provided the means to reduce the cost of sequencing by roughly five orders of magnitude over the last six years. This "next generation" sequencing has enabled sequencing as a basic tool to inquire the state of DNA variation, the transcriptional levels of the multitude of RNAs, the location of transcriptional cofactors, and many other molecular characteristics that can be expressed as an oligonucleotide. This presentation will summarize the technology and showcase several vignettes of current biological and medical interest. 3:45 pm 10

Next generation sequencing: Redefining growth beyond Moore's Law Scott D. Kahn, Illumina, Inc., San Diego, CA 92121, United States The development of highly multiplexed sequencing reactions via clonal oligonucleotide clusters has provided the means to reduce the cost of sequencing by roughly five orders of magnitude over the last six years. This "next generation" sequencing has enabled sequencing as a basic tool to inquire the state of DNA variation, the transcriptional levels of the multitude of RNAs, the location of transcriptional cofactors, and many other molecular characteristics that can be expressed as an oligonucleotide. This presentation will summarize the technology and showcase several vignettes of current biological and medical interest. 4:15 pm Concluding Remarks