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SHAIK AZEEZA
OBJECTIVE
To pursue Postdoctoral position in the area of synthetic organic and medicinal chemistry
such as multidisciplinary drug discovery, drugs based on molecular mechanism,
prodrugs, selective cancer chemotherapy.
EDUCATIONAL BACKGROUND
Ph. D., (Organic/Medicinal Chemistry)
Indian Institute of Chemical Technology (IICT), Hyderabad, India. (2004 till to
date)
Research work towards the “Design and synthesis of new molecules based on
thiolactomycin as potential antitubercular, antimalarial agents and new synthetic
approaches for the precursors of biologically active compounds” (Thesis has been
submitted to Acharya Nagarjuna University, Guntur, India)
Research Supervisor: Dr. Ahmed Kamal, Director Grade Scientist, IICT, Hyderabad,
India
M. Sc., (Organic Chemistry)
Andhra University, Visakhapatnam, India (2003, First Division)
B. Sc., (Chemistry, Physics, Maths)
Acharya Nagarjuna University, Guntur, India (2001, First Division)
Intermediate (Chemistry, Physics, Maths) Board of Intermediate, Hyderabad,
India (1998, First Division)
PERSONAL PROFILE
Male, Indian, born on July 24th, 1981
RESEARCH EXPERIENCE
Four plus years of research training under the guidance of Dr. Ahmed Kamal, an
eminent scientist in the Division of Organic Chemistry at IICT, Hyderabad, India.
Based on SAR studies of thiolactomycin, Design and synthesized more than 30
novel quinolino substituted analogues of thiolactomycin as potential
antitubercular agents
Keeping pace on Drug Resistance (MDR and XDR TB) synthesized a library of
sulfonamide linked analogues of thiolactomycin active against tuberculosis and
malaria
Synthesized the dimers and conjugates of thiolactone and evaluated against
different strains of Plasmodium falciparum.
Synthesized both enantiomers (3S,4R) and (3R,4S) of 3-methoxy-4-
methylaminopyrrolidine a key intermediate for a new quinolone antitumor
compound AG-7352, which claiming as a drug candidature.
Synthesized both the enantiomers of (3R,4R) and (3S,4S)dihydroxy pyrrolodine
by catalytic and biocatalytic approach which are useful intermediates for the
preparation of biologically active Sialyl Lewis X mimetics and novel
carbohydrate mimics.
Developed new approaches towards the synthesis of biologically active
compounds.
Synthesized many pharmaceutically important compounds like fluoxetine,
duloxetine curcumene and curcuphenol with high enantioselectivity.
Lipase mediated resolution of a key intermediate of thiolactomycin has been
developed and configuration was also assigned.
PROJECTS HANDLED
Involved as a key member in the completion of three year collaborative research
project between IICT (INDIA) and University of Capetown (South Africa) under
Department of Science and Technology Programmed for the “Biocatalytic and
combinatorial approaches to novel product based antimalarial and antitubercular
agents” (Year 2004-2007).
AWARDS AND HONORS
Qualified Council of Scientific and Industrial Research (CSIR) examination at the
national level for Junior Research Fellowships (Dec. 2003).
Qualified Council of Scientific and Industrial Research (CSIR) a Senior Research
Fellowship (Aug. 2006).
PROFESSIONAL AND PERSONAL STRENGTHS
Synthesis of library of compounds based on SAR studies
Synthesis of biologically active natural and synthetic products
Design of new drugs based on modification of the drugs that are being known
Study of structure activity relation ship of a new compound
Familiar with mechanism of action of known drugs
Familiar with pharmacology
Acquaintance with biological properties of known and recent drugs
Acquaintance with process of biological evaluation
Development of new and safe methods for the synthesis of pharmaceutically
important compounds
Acquaintance with most of experimental techniques and safe hands on
instruments like HPLC and GC
Interpretation of the structures using 1H NMR, 13C NMR, IR, and various mass
spectrometric data
Capable of both collaborative and independent research
Maintain good interpersonal relationships and excellent communication skills
Knowledge of computers: MS office, Database management packages,
Chemoffice, preparation of research reports, review articles, manuscripts for
publications.
PRESENTATION AT SYMPOSIA
International symposium on “Advanced in organic chemistry”, January 2-6, 2006
Kottayam, India
International symposium on “green/sustainable chemistry”, January 9-15, 2006, at
New Delhi, India
National conference on “National symposium on current trends in chemistry”
January 30-31, 2007, at Kalyani, West Bengal, India
LIST OF PUBLICATIONS
List of reviews
7. Approaches based on enzyme mediated kinetic to dynamic kinetic resolutions: A
versatile route for chiral intermediates
Ahmed Kamal, M. Ameruddin Azhar, Tadiparthi Krishnaji, M. Shaheer Malik and
Shaik Azeeza
Coord. Chem. Rev. 2008, 252, 569-592.
Book
REFERENCES