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GENERAL GYNECOLOGY
sample of 398 women who received elective abortion in an urban hospital. All participants answered demographic, reproductive, and other
questions.
RESULTS: Older women were more likely to have had a previous abor-
tion than teenagers (odds ratio for women 20-29 years old, 2.9 [95%
CI, 1.5-5.7]; odds ratio for women 30 years old, 6.7 [95% CI, 2.8-
16.0]). Alcohol/drug abuse (odds ratio, 2.6; 95% CI, 1.3-5.3) also correlated with increased odds of previous abortion. Depo medroxyprogesterone acetate use approached a significant association (odds ratio,
3.2; 95% CI, 1.0-10.5).
CONCLUSION: The associations between both alcohol/drug abuse and
depo medroxyprogesterone acetate use and repeat abortion are new
findings. Future studies are needed to identify modifiable risk factors
for repeat abortion and to identify populations in which interventions,
such as long-term contraception, may lower the risk.
Cite this article as: Prager SW, Steinauer JE, Foster DG, Darney PD, Drey EA. Risk factors for repeat elective abortion. Am J Obstet Gynecol 2007;197:575.e1575.e6.
575.e1
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General Gynecology
Patients in the first and second trimesters represent very different populations
at our clinic. In general, first-trimester
patients are residents of the city of San
Francisco, but second-trimester patients
are from a larger geographic region. This
is because the Womens Options Center
is the primary abortion clinic in Northern California that provides abortions
after 18 weeks gestation for women with
state-funded insurance, and it is also a
referral clinic for patients with any medical complication in the region. Thus, we
assessed interaction between trimester
and the other variables. In this analysis,
trimester was not found to be an important or significant effect modifier. We
also performed a subanalysis to study the
relationship between all variables and
the outcome of repeat abortion after
stratification by trimester; there were no
significant changes in the results between strata. Therefore, we believed that
trimester was not causing significant interaction, and we adjusted for it by including it in our final model.
R ESULTS
Of the 398 women, 234 (59%) were obtaining a repeat abortion. The participants
were young (mean age, 25 6.5 [SD]
years) and primarily African American
(162 women [41%]) or Latina women
(101 [25%]). Teenaged women were more
likely to be seen for a primary abortion
(65% primary vs 35% repeat), whereas
women in their twenties (38% primary vs
62% repeat) and women aged 30-46 years
(23% primary vs 77% repeat) were more
likely to be seen for a repeat abortion. Most
of the women had lived in the United
States only (316 women [79%]).
Two-thirds of the participants had a
household income over $20,000, and 84%
of the women had some type of insurance,
at least for this pregnancy (ie, Medi-Cal).
Approximately 70% of the participants
had at least a high school education, and
most women considered themselves to be
moderately or very religious (249 women
[63%]). Most of the subjects were single
(258 women [65%]), already had at least 1
child (268 women [67%]), and were using
some method of birth control at the time
of conception (278 women [70%]). Some
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subjects reported conflict with their partner (65 women [16%]) and/or friends or
family (124 women [31%]); only 14 women
(3.5%) reported a history of domestic violence and/or sexual abuse (Table 1).
In the final multivariable model, African
American women were more likely than
Latina women to be seeking a repeat abortion (odds ratio [OR], 2.8; 95% CI, 1.3-5.9;
Table 2). Both white and Asian women
had a higher odds of repeat abortion compared with Latinas, although this did not
reach statistical significance (OR, 1.5; 95%
CI, 0.6-3.5; and OR, 2.1; 95% CI, 0.8-5.1,
respectively). Having lived outside of the
country was found to be associated
strongly with a decreased odds of seeking
repeat abortion (OR, 0.3; 95% CI, 0.1-0.6).
Being seen in the second trimester of this
current pregnancy was found to have a decreased association with repeat abortion
(OR, 0.6; 95% CI, 0.3-.97).
We evaluated markers of socioeconomic status for their associations with
the outcome. In a multivariable model,
neither insurance (OR, 0.7; 95% CI, 0.41.4 for private insurance; OR, 0.8, 95%
CI, 0.4-1.8 for no insurance [self-pay], as
compared with Medi-Cal) nor low income (OR, 1.2; 95% CI, 0.7-2.2) was correlated with repeat abortion. Marital status was not associated significantly with
repeat abortion (OR, 1.8; 95% CI, 0.74.8 for cohabiting; OR, 0.9; 95% CI, 0.84.4 for being single as compared with
married). After being controlled for age,
nulliparity did not have a significant effect on the likelihood of repeat abortion
(OR, 0.9; 95% CI, 0.5-1.7).
The use of any birth control was not
associated significantly with repeat abortion. In bivariable analyses, the use of depot medroxyprogesterone acetate and
oral contraceptive pills were the only 2
birth control methods to be associated
with repeat abortion; however, after adjustment for other variables, only the use
of depot medroxyprogesterone acetate
approached significance (OR, 3.2; 95%
CI, 1.0-10.5).
The abuse of alcohol (as defined by
drinking 3 alcoholic drinks in a day) or
drugs (as defined by using heroin, cocaine, or amphetamines in the previous 6
months) was associated significantly
with increased odds of seeking repeat
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TABLE 1
Baseline characteristics of women who sought abortion that were assessed for repeat abortion risks
Characteristic
Age (y)
P value
.000
.......................................................................................................................................................................................................................................................................................................................................................................
15-19
66 (65.3)
35 (34.7)
20-29
76 (37.6)
126 (62.4)
30-46
22 (23.2)
73 (76.8)
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Race/ethnicity
.000
.......................................................................................................................................................................................................................................................................................................................................................................
Latina
59 (58.4)
42 (41.6)
White
23 (37.1)
39 (62.9)
Asian
24 (53.3)
21 (46.7)
African American
45 (27.8)
117 (72.2)
Other
13 (48.1)
14 (51.9)
54 (65.9)
28 (34.1)
46 (34.3)
88 (65.7)
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
.000
................................................................................................................................................................................................................................................................................................................................................................................
.047
................................................................................................................................................................................................................................................................................................................................................................................
Education
.000
.......................................................................................................................................................................................................................................................................................................................................................................
75 (61.5)
47 (38.5)
62 (32.0)
132 (68.0)
26 (32.1)
55 (67.9)
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Insurance
.746
.......................................................................................................................................................................................................................................................................................................................................................................
80 (39.2)
124 (60.8)
Private
34 (36.6)
59 (63.3)
None (self-pay)
24 (42.9)
32 (57.1)
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.746
................................................................................................................................................................................................................................................................................................................................................................................
Marital status
.021
.......................................................................................................................................................................................................................................................................................................................................................................
Single
118 (45.7)
140 (54.3)
Married
16 (41.0)
23 (59.0)
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
Cohabitating
30 (29.7)
71 (70.3)
98 (35.6)
170 (63.3)
................................................................................................................................................................................................................................................................................................................................................................................
Parous
.007
................................................................................................................................................................................................................................................................................................................................................................................
Menstrual characteristics
.......................................................................................................................................................................................................................................................................................................................................................................
52 (43.0)
69 (57.0)
.636
Irregular periods
39 (43.3)
51 (56.7)
.641
27 (42.2)
37 (57.8)
.862
22 (61.1)
14 (38.9)
.011
33 (33.0)
67 (67.0)
.054
88 (42.5)
119 (57.5)
.582
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
111 (39.9)
167 (60.1)
.430
78 (42.9)
104 (57.1)
.539
................................................................................................................................................................................................................................................................................................................................................................................
Condom user
................................................................................................................................................................................................................................................................................................................................................................................
5 (20.0)
20 (80.0)
.026
14 (28.0)
36 (72.0)
.042
Tubal user
1 (50.0)
1 (50.0)
.655
2 (66.7)
1 (33.3)
.571
15 (39.5)
23 (60.5)
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
.82
575.e3
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General Gynecology
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TABLE 1
Baseline characteristics of women who sought abortion that were assessed for repeat abortion risks
Continued from page 575.e3.
Characteristic
No method user
53 (44.2)
67 (55.8)
P value
.43
................................................................................................................................................................................................................................................................................................................................................................................
Medical barriers
.......................................................................................................................................................................................................................................................................................................................................................................
Abuse of drugs/alcohol
27 (32.9)
55 (67.1)
.087
Obesity
35 (27.6)
92 (72.4)
.000
104 (41.8)
145 (58.2)
.769
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Moderately/very religious
................................................................................................................................................................................................................................................................................................................................................................................
Intrapersonal barriers
.......................................................................................................................................................................................................................................................................................................................................................................
29 (44.6)
36 (55.4)
.542
51 (41.1)
73 (58.9)
.983
6 (42.9)
8 (57.1)
.898
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Prager. Risk factors for repeat elective abortion. Am J Obstet Gynecol 2007.
C OMMENT
Our cross-sectional study identifies 7
characteristics that are correlated independently with repeat abortion in an urban abortion clinic; some are in agreement and others are in contradiction
with previous studies. The association
between increased age and repeat abortion is consistent with other published
data3,10 and, as mentioned earlier, is
more of a confounder than a true association. The association between race and
repeat abortion is also consistent with
other studies,3 because previous research
has indicated that non-white race/ethnicity usually is associated more highly
with repeat abortion. However, in our
population, Latina women were less
likely to seek repeat abortions than African American, Asian, and white women.
The original study that used these data
found that women with a history of a previous second-trimester abortion were
more likely to be seen in the second trimester for their current abortion.8 However,
the analyses from both studies indicate that
a history of any previous abortion actually
had a decreased association with secondtrimester abortion. There are several pos575.e4
sible explanations for the reason that second-trimester abortion has a decreased
association with repeat abortion. Women
who have had a previous abortion may be
more comfortable with abortion as an option and find it easier to make a decision to
abort. This would enable them to be seen
earlier in their pregnancy for their subsequent abortion. Or it could simply be that,
having accessed abortion care previously,
they now know how to navigate the system
and therefore are seen earlier in pregnancy.
By design, this study included equal
numbers of women who were seeking
first- and second-trimester abortions. This
is discrepant with the overall distribution
nationally, with only approximately 12%
of abortions performed in the second trimester.11 In many instances, the characteristics and/or risk factors for women differ
significantly by trimester. Thus, these data
may be skewed toward better representing
women who are seen in the second
trimester.
The original questionnaire did not ask
specifically whether subjects were born in
the United States, but it did ask subjects
whether they had ever lived outside of the
country. This variable was used as a surrogate marker for being foreign born and,
given the low socioeconomic status of
most of the subjects, was felt to be reasonably accurate. This characteristic was also
associated negatively with repeat abortion,
possibly because the cultural beliefs of
women who are born outside of the country (most commonly Latin America in our
sample) make them less likely to use abortion services and therefore less likely to
have had a previous abortion. They may
also be less likely to report a previous abortion, even if they had obtained one previously. Additionally, subjects who come
from Latin America almost uniformly
would not have had access to safe, legal
abortion in their home country,12 which in
itself may have decreased their likelihood
of a previous abortion.
We found no association between insurance and repeat abortion in this
study. Higher rates of Medicaid use
among women who seek repeat abortion
has been reported previously.7 However,
other studies have not further divided
the non-Medicaid group into the separate components of private insurance
and no insurance (self-pay), as we did. It
is possible that the reason we found no
difference among any of these groups is
that almost all women, regardless of economic status, are able to access abortion
in the state of California. It is known that
there is a significantly higher rate of repeat abortion in states that allow Medicaid to pay for abortion services, as compared with states that do not (53% and
44%, respectively).7 Similarly, it is probable that women without any insurance
would be less likely to obtain a repeat
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Research
TABLE 2
Predictor variable
95% CI
P value
Age (y)
.......................................................................................................................................................................................................................................................................................................................................................................
20
Reference
Reference
Reference
20-29
2.86
1.45-5.66
.00
30-44
6.65
2.76-16.0
.00
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Race/ethnicity
.......................................................................................................................................................................................................................................................................................................................................................................
Latina
Reference
Reference
Reference
White
1.46
0.61-3.53
Asian
2.05
0.81-5.14
.13
African American
2.8
1.34-5.85
.00
Other
0.79
0.26-2.41
.68
0.25
0.11-0.56
.00
1.2
0.66-2.18
.56
.......................................................................................................................................................................................................................................................................................................................................................................
.39
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Insurance
.......................................................................................................................................................................................................................................................................................................................................................................
Medi-Cal
Reference
Reference
Reference
Private
0.72
0.37-1.40
.33
None (self-pay)
0.81
0.37-1.79
.61
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Education
.......................................................................................................................................................................................................................................................................................................................................................................
Reference
Reference
Reference
1.59
0.85-3.00
.15
1.91
0.83-4.38
.13
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Marital status
.......................................................................................................................................................................................................................................................................................................................................................................
Married
Reference
Reference
Cohabiting
1.78
0.65-4.82
Reference
.......................................................................................................................................................................................................................................................................................................................................................................
.26
.......................................................................................................................................................................................................................................................................................................................................................................
0.91
0.36-2.28
.84
Single
0.56
0.32-0.97
.04
Nulliparity
0.91
0.48-1.74
.78
Spotting/bleeding
1.75
0.92-3.33
.09
3.22
0.99-10.5
.05
1.58
0.73-3.44
.25
0.8
0.30-2.16
.66
Abuse of drugs/alcohol
2.6
1.28-5.28
.00
Obesity
1.62
0.89-2.96
.11
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
Prager. Risk factors for repeat elective abortion. Am J Obstet Gynecol 2007.
575.e5
Research
General Gynecology
still at higher risk for unintended pregnancy. Or it may be that these women
have an especially strong desire to avoid
an unintended pregnancy, which makes
them more likely to abort if they do become pregnant. It is also possible that
our sample size was too small to find the
expected association between other contraceptive methods and repeat abortion.
Finally, it is important to recognize that
more than two-thirds of the subjects
who sought either a first or repeat abortion were using some method of contraception at the time of conception. This is
higher overall contraception use than the
54% that is usually cited for women seeking abortion.2 It could be that the public
funding for contraception in California
allows for earlier and improved contraception use for all women, even before
they have had 1 unintended pregnancy.
However, this still exemplifies that typical contraception use is not sufficient to
prevent many unintended pregnancies.
This study is the first to find an association between alcohol and/or drug abuse
and repeat abortion. One previous study
looked at this variable and found a positive
association between drug abuse and a history of abortion, as compared with no history of abortion, but there was no difference in the rates of drug abuse in women
who have 1 vs 2 abortions. This association between alcohol and/or drugs and repeat abortion, as found in our study, presents an interesting possibility for targeted
intervention. If women could be convinced to enter treatment programs or to
otherwise decrease their alcohol and drug
use, we might be able to influence their
ability to prevent future unplanned pregnancies. Alternatively, recommending
long-term birth control options for these
higher-risk women would be another possible intervention.
Unlike other studies,4,10 we found no
association between conflict with partner,
family and/or friends, or domestic violence
and/or sexual abuse and repeat abortion.
However, the number of women who reported domestic violence was small (14
women); therefore, we may have missed
an association because of lack of power. In
addition, a history of domestic violence
and/or sexual abuse was elicited by staff
members during their routine counseling
575.e6
sessions and then abstracted by the research assistants from the clinic chart; it
was not a part of the ACASI questionnaire.
This less private method of obtaining the
information may have also contributed to
the low level of reported domestic violence
and/or sexual abuse. The association between domestic violence and/or sexual
abuse and repeat abortion remains of interest for future study, because there is a
potential opportunity for intervention.
Small sample size may explain the lack of
association between repeat abortion and
certain characteristics that displayed significant associations in other studies (ie,
use of birth control). The questionnaire
was not designed originally to study repeat
abortions; thus, other information that
might have been helpful (such as when
previous abortions had occurred, the circumstances that influenced current and
previous decisions, or age at previous pregnancies) was not ascertained. In addition,
there were limited questions about domestic violence and/or sexual abuse, which
may not have been adequate to derive
meaningful results with respect to this
variable. Finally, it is important to realize
that this study was conducted in California, a state where access to abortion is better than in most other states. Repeat abortion in general is more common in states,
such as California, with better access to and
higher rates of abortion.7 However, these
rates may be inflated by women crossing
state borders to access abortion more easily. It is possible that the characteristics of
women who seek repeat abortion may differ, depending on how difficult and expensive it is to access abortion in a specific
state. Therefore, the results from this study
may not be generalizable to states with
more restrictive abortion laws.
To assess more effectively characteristics that are associated with obtaining a
repeat elective abortion, additional studies should be undertaken. Two possible
designs are a cross-sectional analysis of
women who have all had 1 abortion and
are subsequently pregnant again or a
prospective cohort study of women who
are seen for a primary abortion.
It is important to understand risk factors
for repeat abortion so that women who
undergo abortion and who are at higher
risk for repeat abortion can be identified
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and targeted for specific interventions.
Studies of interventions, such as counseling techniques, that are directed towards
these high-risk women could then be done
so that we can reduce their chance of needing a future abortion. In part, repeat abortion represents a failure of the medical
community to help women prevent another unintended pregnancy. It is critical
therefore that we understand this complex
issue to help women gain control of their
reproductive lives.
f
ACKNOWLEDGMENT
We thank Dr Mark Pletcher and Dr Steve Shiboski for their help with epidemiologic and biostatistical issues, respectively.
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