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3
.
WP-EUD rev. 1, 0310
Copyright 2003 RaySearch Laboratories AB All Rights Reserved
Pinnacle
3
and P
3
IMRT are registered trademarks of Philips Medical Systems. NPSOL
\
|
=
=
,
where
i
d is the dose in voxel i , N is the number of
voxels in the ROI, and a is called the volume pa-
rameter, which will be described further below.
In P
3
IMRT the equation is slightly modified to allow
voxels to be only partially included in a region of in-
terest. With
i
v denoting the fraction of the ROI that
is occupied by voxel i , the EUD is calculated as
a N
i
a
i i
d v EUD
1
1
|
|
.
|
\
|
=
=
.
The volume parameter, a
The EUD model is parameterized by one biological
parameter, a . The parameter should be chosen so
that the EUD reflects the intended biological proper-
ties. The choice of a has the following effect on the
EUD value
Effect Suitable organs
1 < a
Lower doses are given
higher weight, so that
cold spots affect the
EUD to a large extent.
Targets.
1 = a
This corresponds to the
mean dose. Cold and
hot spots are given
equal weight.
Parallel organized
normal tissue,
such as lung and
liver.
1 > a
Larger doses are given
higher weight, so that
hot spots affect the
EUD to a large extent
Serial tissue, such
as the spinal cord.
Parameter a may be determined empirically by fit-
ting with dose-volume data. As an alternative, a can
be treated as a freely adjustable parameter whose
value is determined by trial-and-error to achieve the
best dose distributions, which is the ultimate goal.
RaySearch White Paper Biological optimization using the equivalent uniform dose (EUD) in Pinnacle
3
.
WP-EUD rev. 1, 0310
Copyright 2003 RaySearch Laboratories AB All Rights Reserved
Pinnacle
3
and P
3
IMRT are registered trademarks of Philips Medical Systems. NPSOL
\
|
=
EUD
EUD EUD
EUD EUD EUD F ,
where
0
EUD is a dose level specified by the user, and
( )
( ) EUD min for
EUD for target
EUD max for
1 ) , (
0
0
0
=
EUD EUD H
EUD EUD H
EUD EUD ,
where ( ) H is the Heaviside step function. The max
and min EUD objective function have the obvious
interpretations of penalizing too high or too low
EUD values respectively. Target EUD means that any
deviation from the given
0
EUD will be penalized, so
the optimizer will try to achieve exactly that value.
The logical choice of objective functions for a critical
structure is therefore a maximum EUD objec-
tive/constraint with 1 a . The higher the value of a ,
the more effort will be given to avoiding hot spots.
For targets, the logical choice would be a minimum
or target EUD objective/constraint with 1 < a . The
lower the value of a , the more effort will be given to
avoiding cold spots.
References
[1] Niemierko A. A generalized concept of equivalent
uniform dose (EUD). Med. Phys. 26(6):1101, 1999.
[2] J. Lf, Development of a general framework for
optimization of radiation therapy, Stockholm Uni-
versity, 2000.
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