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Generic & Brand Name Generic: Galantamine hydrobromide

Dose, Strength & Formulation Ordered:

Indication/ Mechanisms of Drug Action Indications: -used for the treatment of mild to moderatedementia of the Alzheimer's type.

Adverse/Side Effect Drug Interaction Side effects:

Nursing Responsibilities

Rationale

Client Teaching

Brand: Razadyne

Classification: cholinesterase inhibitors

The most frequent side effects seen with galantamine arenausea (one in six treated persons), vomiting (up to one in ten persons),diarrhea (up to one in eight persons), anorexia (loss of Timing: appetite), and weight loss. These Mechanism of side effects generally occur during Action: the beginning of treatment or when Cholinesterase the dose is increased. These side inhibitors inhibit effects typically are mild and Duration: (block) the action of temporary. Taking galantamine 1 hour acetylcholinesterase, with food and ensuring adequate the enzyme fluid intake may reduce the impact responsible for the of these side effects. Fewer than Other Form: destruction of one in ten persons will need to stop Tablets: 4, 8, treatment due to side effects. In acetylcholine. and 12 mg . Extended Acetylcholine is one one two-year study, 1.3% of patients receiving galantamine died release of several compared to 0.1% of patients capsules: 8, 16, neurotransmitters in receiving placebo. Half of the and 24 mg. the brain, chemicals deaths were due to vascular Oral solution: 4 that nerve cells use to disease (heart attack, stroke) or mg/mL communicate with sudden death which are expected one another. Reduced in an elderly population. levels of Drug Interactions: acetylcholine in the

Assess patients cognitive ability before and after administeri ng the drug and regularly thereafter. Be alert for adverse reactions and drug interaction s.

To monitor drugs effectivenes s.

1. Advise patient and caregiver to report signs and symptoms of bradycardia immediately to the prescriber.
2. Instruct S.O. to let

the patient take drug with or without food. To establish proper precautiona ry measures when adverse reactions or drug interactions occur. 3. Inform patient and family that the drug doesnt alter underlying degenerative disease. 4. Explain to the patient and family that the effect of therapy depends on taking the drug at regular intervals.

brain are believed to be responsible for some of the symptoms of Alzheimer's disease. By blocking the enzyme that destroys acetylcholine, galantamine increases the concentration of acetylcholine in the brain, and this increase is believed to be responsible for the improvement in thinking seen with galantamine.

Drugs with anticholinergic properties and which cross into the brain, such as atropine, benztropine (Cogentin), and trihexyphenidyl (Artane) produce opposite effects of (counteract) galantamine and should be avoided during therapy with galantamine. Unlike donepezil (Aricept), galantamine does not increase blood levels of other medications and increase their risk for side effects.

Assess patients and familys knowledge of drug therapy.

To ensure that family follows appropriate drug regimen.

5. Advise patient and caregivers to report immediately any significant adverse effects or changes in status.