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SFARI NEWS

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27 March 2012

A Newsletter from the Simons Foundation Autism Research Initiative

NEWS Researchers seek 'active ingredients' of early intervention Scientists link new deficits to FOXP2 mutations in mice IN BRIEF Cognition and behavior: Mirror neurons age normally in autism Genetics: Autism risk higher in full than in half siblings Molecular mechanisms: Maternal infection linked to autism TOOLBOX Online tool can predict effects of genetic variants BLOG Big neuroscience Adolescent woes

NEWS

Researchers seek 'active ingredients' of early intervention


Early intensive intervention is the only therapy that has been shown to be effective in young children with autism, according to a 2011 review of autism treatments commissioned by the U.S. Agency for Healthcare Research and Quality. But researchers are just beginning to tease out what they refer to as its 'active ingredients.' Read More >

Scientists link new deficits to FOXP2 mutations in mice


Mice with mutations in a gene tied to language impairment and to autism have trouble learning to associate sounds with motor patterns, says a study published last week in PLoS ONE.

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SFARI NEWS

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IN BRIEF

Cognition and behavior: Mirror neurons age normally in autism


Age-related changes to the mirror neuron system a pathway thought to be involved in empathy are no different in individuals with autism compared with controls, according to a meta-analysis published 1 February in Social Cognitive and Affective Neuroscience.

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Genetics: Autism risk higher in full than in half siblings


Full siblings are twice as likely as half siblings to share a diagnosis of autism, according to a short report published 28 February in Molecular Psychiatry. The results suggest that genetic factors play an important role in the risk of developing autism, the researchers say.

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Molecular mechanisms: Maternal infection linked to autism


Molecules generated by an immune reaction in pregnant mice affect the brains of their offspring, leading to changes in gene expression, according to a study published 30 January in Brain, Behavior and Immunity.

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TOOLBOX

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SFARI NEWS

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Online tool can predict effects of genetic variants


Researchers have developed a tool that can predict whether DNA mutations that change a single base pair are likely to alter RNA splicing, a process that modifies the sequence of mRNA, the genetic message that codes for protein. The results were published 10 February in Bioinformatics.

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BLOG

Big neuroscience
Two large-scale neuroscience projects aim to integrate many different types of information about the brain into cohesive models and to share resources with the research community.

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Adolescent woes
Adolescents with autism report lower quality of life when it comes to relationships, but a better self-image and relationships with parents and teachers than do their typically developing peers, including those with diabetes.

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