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Abstract No: P.

37-04

COMPARATIVE STUDY OF THE EFFICACY OF GLEPTOFERRON AND IRON DEXTRAN


IN ANAEMIA PREVENTION IN PIGLETS

E Salle1, V Auvigne2
1
CEVA Santé Animale, LIBOURNE CEDEX, France
2
Ekipaj, ST GREGOIRE, France

Introduction 11.0
Clinical iron-deficient anaemia is very rare these days, as 10.5
the administration of iron to piglets during their first days 10.0

of life is a systematic practice in most pig farms. 9.5

Hg level at day 0 (g/dl)


9.0
Nevertheless, different molecules and different
8.5
administration routes are used, their relative efficacy is

levels at T0
8.0
currently under discussion. Gleptoferron (Gleptosil®, 7.5
CEVA), is a sterile aqueous colloidal solution of beta- 7.0
ferric oxyhydroxide and dextran glucoheptonic acid. In this 6.5

Hb
multicentric field study, Gleptoferron was compared to 6.0

injectable iron dextran for the prevention of iron-deficient 5.5


5.0
anaemia in piglets.
0 1 2 3 4 5 6
Age Age
at T0at(days)
day 0
Materials and Methods
A field study was carried out in 8 farrow-to-finish farms in Figure 1 Relation between age at T0 and Hb level at T0
France between December 2004 and December 2005. A (box-whiskers plot indicates mean-1 SD and 2 SD)
total of 60 litters (5 to 10 per farm) were monitored. Ten
piglets of each litter were randomly divided in two groups Haemoglobin levels after treatment
of five: the ‘gleptoferron’ and the ‘iron dextran’ group. At Haemoglobin levels after treatment (T1) was significantly
T0 (0 to 6 hours after birth), the piglets were identified, higher in piglets of the ‘gleproferron’ group when
and their level of haemoglobin was measured after which compared to the ‘iron dextran’ group (11.3 vs. 10.8 g/dl,
the piglets received 200 mg iron (gleptoferron or iron Table 1).
dextran, according to the randomised group) by IM
injection. The level of haemoglobin was measured again at Table 1 Evolution of haemoglobin levels between groups
the time of weaning (T1, 16 to 31 days after birth i.e. 14 to
31 days after the iron injection). Haemoglobin (g/dl)
gleptoferron iron dextran p
Analysis was carried out in the field using an instant, T0 (before injection) 8.40 8.38 0.84
pocket-sized quantitative Haemoglobin analyser (Hemocue
Hb 201 +, www.hemocue.com). Analysis was carried out T1 (at weaning) 11.27 10.83 0.001
in 607 piglets at T0 and 526 piglets at T1.
Discussion
Statistical analysis was carried out using the t-Test for This study was carried out in the field in farms located far
correlated samples, considering litters as a statistical unit from each other, and it was not possible to sample all
(http://vassun.vassar.edu). For each group within each animals at the same age. Since the daily iron needs of the
litter, the average level of haemoglobin was calculated at piglet are much higher than their intake by milk
T0 and T1. The animals of which the haemoglobin could (15 mg/day vs. 1 mg/day), it seems logical that the level of
not be checked at T1 were excluded from the study. haemoglobin at T0 is correlated to the piglet’s age.
Nevertheless, since each litter was subdivided into two
Results groups, a comparison of the groups is possible.
Haemoglobin levels before treatment
The average haemoglobin level of piglets at T0 was 8.4 In this study, piglets that received gleptoferron had a
g/dl. There was a significant correlation (Anova, p=0.003) higher level of haemoglobin at weaning than the group
between the age at the first blood sample and the level of receiving iron dextran. This indicates a higher
haemoglobin. This effect was particularly notable in bioavailability of gleptoferron. This difference was not
piglets that were sampled between days 3 and 6 of age observed in previous studies, which were carried out in a
(Fig. 1). There was no significant difference between the single farm on a lower number of litters (1, 2).
‘gleptoferron’ and ‘iron dextran’ groups (Table 1).
References
1. Pollmann DS, et al. (1983) J Anim Sci., 56(3):640-4.
2. Vermeer JE, et al. (2002) Tijdschr Diergeneeskd.
127(4):110-4.

Proceedings of the 19th IPVS Congress, Copenhagen, Denmark, 2006 · Volume 2 567

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