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Source
Pinderfields General Hospital, Wakefield.
Abstract
PURPOSE OF STUDY: To compare both the speed of onset and efficacy of the analgesia produced by the effervescent granule formulation with that produced by the conventional-release tablet formulation of ibuprofen in patients suffering acute dental pain and to record the incidence and severity of any adverse events. POPULATION STUDIED: Dental out-patients of either sex and over 16 years of age requiring surgical removal of unilateral or bilateral lower third molar teeth under general anaesthesia as day cases. METHODS: A total of 50 patients received the effervescent granules formulation of ibuprofen 600 mg (Brufen Granules) as study treatment and 50 received the 600 mg tablet formulation in this investigator-blind, parallel-group multiple-dose study. Surgery was performed under general anaesthesia by one or two dental surgeons. Patients received either one sachet of ibuprofen granules or one tablet of ibuprofen at six-hourly intervals for up to 24 hours once postoperative pain became moderate to severe. FINDINGS: Both treatments were shown to be efficacious in treating post-operative dental pain. The granules were found to give significantly better pain relief in the first 30 minutes following the first dose. This may be owing to a more rapid absorption from the granules formulation in these patients and/or a local action of ibuprofen in solution in the mouth. CONCLUSION: The effervescent soluble form of ibuprofen (Brufen Granules) is preferable to the conventional tablet form in managing the immediate dental pain experienced post-operatively by most patients because of its faster onset of action.
[Evaluation of the antipyretic safety and accuracy of two pediatric ibuprofen formulations].
[Article in Spanish] Dez Domingo J, Planelles Cantarino MV, Moreno Madrid F, Uberos Fernndez J, Moreno Martn J, Molina Carballo A, Antelo Cortizas J, Armenteros Gonzlez S, Domnguez Granados R, Moreno Carretero E.
Source
Centro de Salud de Nazaret. Valencia. diez_jav@gva.es
Abstract
AIM: To compare the efficacy and to evaluate the clinical bioequivalence of two different formulations of ibuprofen (suspension and effervescent granules) in febrile children. METHODS: An open, randomized, multicenter study. Febrile children (axillary temperature 38 degrees C) weighing more than 25 kg, admitted into the emergency departments of the participating hospitals were randomly assigned to either of the two treatment groups: ibuprofen suspension (7 mg/kg) or effervescent granules at the following dosages: 200 mg in children weighing 2540 kg or 400mg in children weighing 3540 kg and with an axillary temperature above 39 degrees C. This latter dose of 400 mg was also given to children weighing more than 40 kg.The investigators took axillary temperature before treatment and 30, 60, 90, 120, 180 and 240 min after administration of the corresponding dose. Possible adverse events were noted. RESULTS: A total of 103 patients were included in the study; 51 received the effervescent granules and 52 received the suspension formulation. The mean temperature was reduced in both groups during the study (p < 0.005). No differences were found between the formulations. The mean differences of temperatures at each point of the study were within the clinical bioequivalence interval (+/-0.5 degrees C). Only one patient had an axillary temperature of 35.9 degrees C. This was the only adverse event recorded in the study. CONCLUSIONS: Both ibuprofen formulations were effective in reducing fever and may be considered clinically bioequivalent.
Source Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya Sagar, India. Abstract Proliposomes of ibuprofen were successfully prepared using effervescent granules as solid carriers of dried phospholipids along with other lipids (soyabean lecithin, stearylamine and cholesterol). Liposomes of regular size with uniform size distribution resulted when proliposomal formulations were hydrated under the effervescence produced by the production of carbon dioxide gas. The inert atmosphere of carbon dioxide gas prevents the chance of oxidative degradation of phospholipids. The size distribution of liposomes was noted to be related to the degree of agitation provided by effervescence. Encapsulation efficiency of liposomes derived from proliposomes was shown to be nearly 100 per cent. Preparations were shown to be quite stable at 20 degrees C when stored under an umbrella of nitrogen. The enhanced anti-inflammatory activity of ibuprofen entrapped in liposomes was exhibited when compared with plain ibuprofen following intravenous administration using the carrageenan induced paw oedema test
Source
Department of Pharmaceutical Sciences, Dr H.S. Gour Vishwavidyalaya, Sagar, India.
Abstract
Plain liposomal systems composed of soyabean lecithin, cholesterol and stearylamine were formulated using various approaches. The prepared products were characterized and evaluated for their cytoprotective performance against the necrotizing NSAID's (i.e. aspirin and phenylbutazone). Liposomes derived from proliposomes (effervescent granules based) demonstrated the best cytoprotective activity and physical and stability characteristics. This system was shown to be superior. An increased availability of regular and small sized liposome born phospholipids to the damaged mucosal systems accounted for its better and enhanced performance.