Module Outline Form

Module code: CHY8420

Module Title: Organic Synthesis for Drug Targets
Short Title: Organic Synthesis for Drug Targets
0
Semester 1 credits: Semester 2 credits:
10
Semester 3 credits:
0
ECTS credits:
5.0
FHEQ Level : 7
Owning School : Chemistry
Prof. Michael North Lecturer 50
Dr Julian Gary Knight Module Leader 50
Full Name Contributor Description % Contribution
4
Support Staff Requirements:
N/A 0
Other Institution(s): Proportion of teaching %
PreRequisites :
CHY3101 Advanced Organic Chemistry
Code Short Title
CoRequisites :
PostRequisites :
F124 MChem Medicinal Chem (Ind Train) Yes No No
F107 MChem Chemistry with Study in Europe Yes No No
F123 MChem with Hons in Medicinal Chemistry Yes No No
F106 MChm Hon Chemistry (Industrial Training) Yes No No
F103 MChem with Hons in Chemistry Yes No No
F105 MChem Chemistry with study in N America Yes No No
Code Title Optional Compulsory Core
Other Programme Links :
Academic Year:
Equivalent Modules :
ModuleRole(s) :
Programme Links:
Stage
2011/12 Active: Yes
CHY8820 Organic Synthesis for Drug Targets
Max Capacity:
999
Date:29/03/2011,08:40AM
Mode : Linear Stand alone : Not Available
Availability:
Annually
Aims:
To familiarise students with the key strategies for the stereocontrolled synthesis of organic compounds; to
provide practise in identifying and applying such strategies; to exemplify the principles in the context of the
synthesis of drug targets
Module Summary:
The lectures cover the principles of stereocontrol, regioselectivity, and asymmetric synthesis including:
directed reactions, the Felkin-Ahn model, chelation control, 1,3-allylic strain, chiral auxiliaries, chiral
catalysis, bidirectional chain synthesis double stereodifferentiation, and chiral amplification.
Outline of Syllabus:
ntroduction to synthetic strategy, selectivity and specificity
Regioselectivity
Stereoselectivity
The aldol reaction
Seminar
Asymmetric synthesis. Use of the chiral pool
Chiral auxiliaries
Chiral catalysts
Enzymes in organic synthesis
The use of symmetry
Double stereodifferentiation
Chiral amplification
Seminar
Workshops illustrating, expanding, and consolidating the reactions and principles introduced above in the
context of the synthesis of organic drug targets
Is the module suitable for study abroad students? No
Intended Knowledge Outcomes:
recognise and be able to comment on different synthetic strategies and methods for stereocontrol when
faced with a synthetic scheme
understand the different classes of 'selectivity' and 'specificity'
understand and be able to use the Felkin-Anh model, chelation control, and 1,3-allylic strain to predict the
stereoselectivity of reactions
know about the chair transition state model to explain the stereochemical outcome of reactions when
appropriate (such as enolisations and the aldol reaction)
understand the ideas of topicity, double stereodifferentiation, and chiral amplification
be aware of typical reagents and transformations used in modern organic synthesis
Intended Skill Outcomes:
Subject specific or professional skills, able to:
identify aspects of selectivity and specificity within a given synthetic scheme
Cognitive or intellectual skills, able to:
make a reasoned choice of theoretical model
apply this model in order to predict or explain an observed outcome.
Key skills, able to:
plan coursework effectively
take notes
Graduate Skills Framework:
Cognitive / Intellectual Skill
P - Present, A - Assessed
Teaching and learning methods:
Method Number Length Student Hours Academic Staff
Contact Hours
Lectures:
Seminars:
Tutorials:
Practicals:
Fieldwork:
Private Study:
16 001:00 016:00 016:00
5 001:00 005:00 005:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Class Tests:
Group Learning:
0 0:00 0:00 0:00
0076:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Other method(s)
workshops
3 000:00 003:00 003:00
Description Number Length Student Hours Staff Hours
Total Hours : 024:00 0100:00
Information Literacy
Critical Thinking: Data Synthesis:
Active learning : P Numeracy: A
Literacy: P
Source materials: Synthesise and Present Materials:
Use of Computer Application
Self Management
Self-awareness and Reflection P
Planning & Organisation
Goal setting & action planning: Decision Making:
Personal Enterprise
Innovation and Creativity: Initiative:
Independence: P Adaptability:
Problem Solving A
Budgeting:
Interaction
Communication
Oral: Foreign Languages:
Interpersonal: Written/Other:
P
Team Working
Collaboration: Relationship Building:
Leadership: Negotiation:
Peer Assessment/Review:
Application
Occupational Awareness:
Commercial Acumen
Market Awareness: Governance Awareness:
Financial Awareness: Business Planning:
Ethical Awareness: Social, Cultural & Global Awareness
Legal Awareness:
Timetabling Information:
Two sessions per week over one semester. These sessions follow a cycle of three lectures followed by one
seminar.
The final three sessions are workshops.
Approx Student Numbers:
20
Rationale and relationship to learning outcomes:
The course involves the introduction of a set of principles which may be applied to the analysis and design
of organic synthesis. These principles are addressed in the 16 lectures. These basic principles are
consolidated in 5 seminars (which are spread out over the course) in which problems, each focussing on a
particular example, and attempted in advance by the students, are discussed. The final series of workshops
involve discussion of the application of these principles in the context of total synthesis of drug targets and
serve to draw together the various strands of the course.
Stereoselectivity in
Organic Synthesis
G Procter,
Oxford
Chemistry
Primer
Oxford University Press
1998
019855957
7
No Yes No
Asymmetric Synthesis G Procter Oxford University Press
1996
019855725
6
No Yes No
Asymmetric Synthesis of
Natural Products
A Koskinen Wiley 1993 047193848
3
No Yes No
Principles and
Applications of
Stereochemistry
M North STP 1998 075140420
9
No Yes No
Organic Chemistry J Clayden, N
Greeves, S
Warren, P
Wothers
Oxford University Press,
2000
019850346
6
Yes No No
Title Author Notes ISBN Essent. Bkgrnd. Recmd.
Written Examination 120 2 100
Type Length
(mins)
When Set % of formal
assessment
Comment for assessment
Assessment rationale and relationship:
The written paper will consist of problem-oriented questions, some of which focus on a particular principle or
set of related principles and some which require broader analysis. This is deemed an appropriate method of
ascertaining the principles introduced in the course and to the extent to which they can apply these to
unfamiliar situations.
Resits will normally be by examination only.
CHY8820 Organic Synthesis for Drug Targets
Code Short Title
Jointly taught with:
Reading References:
Exams:
Exams Pairing Requirements:
Other Assessment:
Chemistry Chemistry 100
Academic Cost Centre Jacs Subject Code Subject Proportional
Split (%)
01/01/2005 Signed by Head of School(s) or nominee:
Immunisation / Allergy Screening (complete only if module is taken by non-clinical students)
Immunisation Should be offered (yes/no
Hepatitis A:
Hepatitis B:
Tetanus:
Allergy Screening:
No
No
No
No
Handbook Text:
General Notes:
Hesa Data:
Internal Resourcing:
Module Outline Form
Module code: CHY8421
Module Title: Advanced Methods in Drug Discovery
Short Title: Advanced Methods in Drug Discovery
10
Semester 1 credits: Semester 2 credits:
0
Semester 3 credits:
0
ECTS credits:
5.0
FHEQ Level : 7
Owning School : Chemistry
Dr Celine Cano Other Staff 10
Prof. Roger John Griffin Other Staff 10
Dr Ian Robert Hardcastle Module Leader 80
Full Name Contributor Description % Contribution
4
Support Staff Requirements:
N/A 0
Other Institution(s): Proportion of teaching %
PreRequisites :
CHY3101
CoRequisites :
PostRequisites :
F124 MChem Medicinal Chem (Ind Train) No Yes No
F107 MChem Chemistry with Study in Europe Yes No No
F123 MChem with Hons in Medicinal Chemistry No Yes No
F106 MChm Hon Chemistry (Industrial Training) Yes No No
F103 MChem with Hons in Chemistry Yes No No
F105 MChem Chemistry with study in N America Yes No No
Code Title Optional Compulsory Core
Other Programme Links :
Availability:
Annually
Academic Year:
Equivalent Modules :
ModuleRole(s) :
Programme Links:
Stage
2011/12 Active: Yes
Max Capacity:
999
Date:29/03/2011,08:43AM
Mode : Linear Stand alone : Not Available
Aims:
To demonstrate the role of combinational synthesis in drug discovery; to provide students with an
understanding of the historical development of combinational methods; to introduce the concepts of solid-
phase synthesis and resin- assisted synthesis; to provide students with an understanding of radioisotopes in
medical imaging.
Module Summary:
This module gives a thorough overview of the methods used to discover drugs in use today. The synthesis
and use of combinatorial libraries of both peptides and small drug-like molecules is covered in detail. The
synthesis and uses of radioisotopically labelled drugs is discussed in depth.
Outline of Syllabus:
Peptide synthesis
Peptide libraries strategies and applications
Small-molecule libraries synthesis and applications
Technology in drug discovery
Synthesis of radiolabelled compounds
Applications in medical imaging
Is the module suitable for study abroad students? Yes
Intended Knowledge Outcomes:
thoroughly understand the application of solid-phase methods in the synthesis of peptides, peptide
libraries, and small molecule libraries
thoroughly understand the different combinational techniques including split-mix synthesis and multiple
parallel synthesis
know about a range of solid - phase reactions
know about a range of commonly used radioisotopes and practical aspects relating to their use in a range
applications
Intended Skill Outcomes:
Subject specific or professional skills, able to:
assess the most appropriate technology to apply to a given combinational library synthesis
discuss advantages and disadvantages of specific isotopes in a given application
Cognitive or intellectual skills, able to:
recognise amino acid residues by name, structure and three letter codes
design combinational routes to target molecules
design routes to radiolabelled compounds
solve problems in synthesis
Key skills, able to:
plan and organise coursework effectively
access given references from the library
Graduate Skills Framework:
Cognitive / Intellectual Skill
Information Literacy
Critical Thinking:
P - Present, A - Assessed
Data Synthesis:
Active learning : P Numeracy: A
Literacy: P
Source materials: Synthesise and Present Materials:
Use of Computer Application
Self Management
Self-awareness and Reflection P
Planning & Organisation
Goal setting & action planning: Decision Making:
Teaching and learning methods:
Method Number Length Student Hours Academic Staff
Contact Hours
Lectures:
Seminars:
Tutorials:
Practicals:
Fieldwork:
Private Study:
22 001:00 022:00 022:00
2 001:00 002:00 002:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Class Tests:
Group Learning:
0 0:00 0:00 0:00
0076:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Other method(s)
Timetabling Information:
2 lectures per week. Data projector required. Preference for BEDB LT3 or BTC
Approx Student Numbers:
20
Rationale and relationship to learning outcomes:
CHY8821 Modern Methods in Drug Discovery 1
Code Short Title Semester
Jointly taught with:
Total Hours : 024:00 0100:00
Personal Enterprise
Innovation and Creativity: Initiative: P
Independence: P Adaptability:
Problem Solving A
Budgeting:
Interaction
Communication
Oral: Foreign Languages:
Interpersonal:
P
Written/Other:
A
Team Working
Collaboration: Relationship Building:
Leadership: Negotiation:
Peer Assessment/Review:
Application
Occupational Awareness:
Commercial Acumen
Market Awareness: Governance Awareness:
Financial Awareness: Business Planning:
Ethical Awareness: Social, Cultural & Global Awareness
Legal Awareness:
Key concepts and supporting examples are delivered by lectures.
Concepts are reinforced and skills practiced during problem solving seminars
Written assignments allow students to access and review representative primary literature adding depth to
conceptual understanding
Solid - supported
combinatorial and parallell
synthesis of small -
molecular -weight
compound libraries
D Obrecht
and JM
Villalgordo
Pergamon , 1998 008043257
3
Yes No No
Medicinal Chemistry
Principles and Practice
FD King RSC 2002 085404613
1
No No Yes
Combinational Chemistry NK Terrett Oxford 1998 019850219
2
Yes No No
Title Author Notes ISBN Essent. Bkgrnd. Recmd.
Written Examination 120 1 80
Type Length
(mins)
When Set % of formal
assessment
Comment for assessment
Other 1 20
Type When Set % of formal
assessment
Comment for assessment
Assessment rationale and relationship:
Written examination assesses learning across the taught course material
Written assessment tests students' conceptual understanding of primary literature in the subject area
Resits will normally be by examination only.
For resits taken at the next normal occasion, course work components will be included and may be retaken
by internal candidates.
CHY8821 Modern Methods in Drug Discovery
Code Short Title
Chemistry Chemistry 100
Academic Cost Centre Jacs Subject Code Subject Proportional
Split (%)
01/01/2005 Signed by Head of School(s) or nominee:
Immunisation / Allergy Screening (complete only if module is taken by non-clinical students)
Immunisation Should be offered (yes/no
Hepatitis A:
Hepatitis B:
Tetanus:
No
No
No
Reading References:
Exams:
Exams Pairing Requirements:
Other Assessment:
Hesa Data:
Internal Resourcing:
Allergy Screening: No
Handbook Text:
General Notes:
Module Outline Form
Module code: CHY8422
Module Title: Further Organic Chemistry
Short Title: Further Organic Chemistry
10
Semester 1 credits: Semester 2 credits:
0
Semester 3 credits:
0
ECTS credits:
5.0
FHEQ Level : 7
Owning School : Chemistry
Dr Julian Gary Knight Lecturer 50
Dr Michael John Hall Module Leader 50
Full Name Contributor Description % Contribution
4
Support Staff Requirements:
N/A 0
Other Institution(s): Proportion of teaching %
PreRequisites :
CHY3101 Advanced Organic Chemistry
Code Short Title
CoRequisites :
PostRequisites :
F124 MChem Medicinal Chem (Ind Train) Yes No No
F107 MChem Chemistry with Study in Europe Yes No No
F123 MChem with Hons in Medicinal Chemistry Yes No No
F106 MChm Hon Chemistry (Industrial Training) Yes No No
F103 MChem with Hons in Chemistry Yes No No
F105 MChem Chemistry with study in N America Yes No No
Code Title Optional Compulsory Core
Other Programme Links :
Availability:
Academic Year:
Equivalent Modules :
ModuleRole(s) :
Programme Links:
Stage
2011/12 Active: Yes
Max Capacity:
999
Date:29/03/2011,08:44AM
Mode : Linear Stand alone : Not Available
Annually
Aims:
To introduce and develop the concepts of thermal and photochemical pericyclic reactions and Frontier
Molecular Orbital (FMO) theory; to describe the methods used to determine the mechanisms of such
reactions; to discuss radical chemistry; to explore reactions involving radicals and ions in cyclisation
reactions.
Module Summary:
There are numerous reactions in organic chemistry that involve cyclic transition states and these have a
wide range of applications in synthesis, biological processes, industry and mechanistic study. This module
will explore the underlying chemistry of such reactions, their theoretical basis and their utility.
Outline of Syllabus:
Concerted and stepwise mechanisms
Frontier Molecular Orbital Theory
Pericyclic reactions and orbital symmetry
Thermal and photochemical processes
Cycloaddition Reactions
Electrocyclic Reactions
Sigmatropic Rearrangements
Determination of reaction mechanism
Anionic and cationic cyclisations (eg biomimetic synthesis)
Radicals: formation, structure, properties and stability
Radical reactions: chain reactions, ring closure reactions, cascade reactions
Baldwin's rules
Kinetics of ring closure reactions
Transition metal mediated cyclisations
Applications of radical chemistry in synthesis
Is the module suitable for study abroad students? Yes
Intended Knowledge Outcomes:
understand Frontier Molecular Orbital (FMO) theory
know the major types of pericyclic reactions
know how to investigate reaction mechanism
understand the chemistry of radicals
know how radicals and ions are involved in cyclisation reactions
know Baldwin's rules
know a range of applications of reactions that go through cyclic transition states in synthesis and
mechanistic study
Intended Skill Outcomes:
Subject specific or professional skills, able to:
interpret experimental evidence and use this to elucidate reaction mechanisms
apply FMO theory appropriately
apply Baldwin's rules to ring closure reactions
Cognitive or intellectual skills, able to:
draw curly arrow mechanisms for a wide range of reactions that proceed via cyclic transition states
solve problems of synthesis and mechanism with respect to such reactions
analyse the kinetics of ring closure reactions
Key skills, able to:
search the primary scientific literature to identify examples of relevance to the module
Graduate Skills Framework:
Cognitive / Intellectual Skill
Critical Thinking:
P - Present, A - Assessed
Data Synthesis:
Active learning : P Numeracy: A
Teaching and learning methods:
Method Number Length Student Hours Academic Staff
Contact Hours
Lectures:
Seminars:
Tutorials:
Practicals:
Fieldwork:
Private Study:
16 001:00 016:00 016:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Class Tests:
Group Learning:
0 0:00 0:00 0:00
0080:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Other method(s)
Workshops
4 001:00 004:00 004:00
Description Number Length Student Hours Staff Hours
Timetabling Information:
Total Hours : 020:00 0100:00
Information Literacy
Literacy: P
Source materials: Synthesise and Present Materials:
Use of Computer Application
Self Management
Self-awareness and Reflection P
Planning & Organisation
Goal setting & action planning: Decision Making:
Personal Enterprise
Innovation and Creativity: Initiative: P
Independence: P Adaptability:
Problem Solving A
Budgeting:
Interaction
Communication
Oral: Foreign Languages:
Interpersonal:
P
Written/Other:
A
Team Working
Collaboration: Relationship Building:
Leadership: Negotiation:
Peer Assessment/Review:
Application
Occupational Awareness:
Commercial Acumen
Market Awareness: Governance Awareness:
Financial Awareness: Business Planning:
Ethical Awareness: Social, Cultural & Global Awareness
Legal Awareness:
2 lecture slots per week (data projector required)
Approx Student Numbers:
15
Rationale and relationship to learning outcomes:
In lectures student learn advanced concepts in the organic chemistry of reactions involving cyclic transition
states which, encompasses synthetic, theoretical and mechanistic principles. In workshops they apply
learnt material to solve problems.
Frontier Orbitals and
Organic Chemical
Reactions
I Fleming Wiley
1976
047101819
8
No Yes No
Organic Reactions and
Orbital Symmetry
TL Gilchrist
RC Storr
Out of print; copies
available from the
Robinson library
No Yes No
Organic Chemistry J Clayden
N Greeves
S Warren
PWothers
Oxford University Press
2000
019850346
6
Yes No No
Title Author Notes ISBN Essent. Bkgrnd. Recmd.
Written Examination 120 1 100
Type Length
(mins)
When Set % of formal
assessment
Comment for assessment
Assessment rationale and relationship:
The examination will test the students' knowledge and understanding of the content of this module in the
context of both synthetic and mechanistic chemistry.
Resits will normally be by examination only.
Chemistry Chemistry 100
Academic Cost Centre Jacs Subject Code Subject Proportional
Split (%)
01/01/2005 Signed by Head of School(s) or nominee:
Immunisation / Allergy Screening (complete only if module is taken by non-clinical students)
Immunisation Should be offered (yes/no
Hepatitis A: No
Jointly taught with:
Reading References:
Exams:
Exams Pairing Requirements:
Other Assessment:
Hesa Data:
Internal Resourcing:
Hepatitis B:
Tetanus:
Allergy Screening:
No
No
No
Handbook Text:
General Notes:
Module Outline Form
Module code: CHY8423
Module Title: Advanced Topics in Contemporary Physical Chemistry
Short Title: Advanced Topics
0
Semester 1 credits: Semester 2 credits:
10
Semester 3 credits:
0
ECTS credits:
5.0
FHEQ Level : 7
Owning School : Chemistry
Dr Ulrich Baisch Lecturer 30
Dr Benjamin Richard Horrocks Lecturer 30
Prof. Anthony Harriman Module Leader 40
Full Name Contributor Description % Contribution
4
Support Staff Requirements:
N/A 100
Other Institution(s): Proportion of teaching %
PreRequisites :
CHY3201 Advanced Physical Chemistry
CHY2201 Physical Chemistry
Code Short Title
CoRequisites :
an industrial placement
PostRequisites :
F106 MChm Hon Chemistry (Industrial Training) Yes No No
F107 MChem Chemistry with Study in Europe Yes No No
F123 MChem with Hons in Medicinal Chemistry Yes No No
F105 MChem Chemistry with study in N America Yes No No
F103 MChem with Hons in Chemistry Yes No No
Code Title Optional Compulsory Core
Other Programme Links :
Availability:
Academic Year:
Equivalent Modules :
ModuleRole(s) :
Programme Links:
Stage
2011/12 Active: Yes
Max Capacity:
999
Date:29/03/2011,08:45AM
Mode : Linear Stand alone : Not Available
Annually
Aims:
To describe modern advances in applied physical chemistry by reference to three selected topics; namely,
advanced electrochemistry, crystallography and electron-transfer reactions. Included are the basic
principles involved in each topic and a logical development of the subject. Attention is given to modern
aspects of the field and to the application of that topic to contemporary research issues. Emphasis will be
given to practical aspects of the technique, without recourse to detailed mathematical approaches.
Module Summary:
Contemporary physical chemistry makes important contributions to all areas of science. This module, which
sets out to avoid mathematics, will highlight recent advances in three separate fields; namely, (A)
electrochemistry, (B) crystallography and (c) electron-transfer processes. A field day will be used to
demonstrate many of the important techniques and to indicate how the science fits in a modern research
laboratory.
Electrochemistry (Section A) is the science at the interface of electronics and chemistry and is the basis of
numerous applications in sensing, clean energy technology and medicine. The course will cover the
fundamentals of electrode reactions and will be illustrated with examples of modern electrochemical
technologies.
Section B will discuss process of crystal growth and the different methods to obtain crystalline materials.
This leads naturally to an advanced knowledge of the various analytical methods available to characterise
crystalline materials. Attention will then be given to understanding some important relationships between
the crystal structure of a solid and its physical or chemical properties. Examples of advanced materials will
be used where the relationship between structure and function becomes evident.
Electron transfer (Section C) is the single most important type of chemical process and is responsible for an
enormous range of chemical and biochemical reactions. Such processes underpin the emerging field of
molecular electronics. Here, we extend the field of electron-transfer chemistry (Marcus theory) to include
biopolymers, light-emitting diodes and molecular computers.
Outline of Syllabus:
Section A covers the principles of electrochemical cells and potentio-stats, including the electrical double
layer. Attention then turns to mass transport under stead-state conditions before addressing transient
electrochemistry. Further consideration is given to impedance spectroscopy and dual-electrode techniques,
the latter being ideal for measuring electrode kinetics and mechanisms. The importance of electrochemical
mechanisms in chemical reactions such as corrosion and catalysis will be explored.
Section B aims to provide an overview on how to obtain and analyse crystalline materials using the new
synthetic approach of Crystal Engineering and modern state-of-the-art techniques. Furthermore, the
relationship between structure and function (the physical or chemical property of a crystalline compound)
will be explained. Examples of compounds will be discussed to explain the underlying methods and theory.
Section C covers the basic principles of electron and proton transfer in molecular systems. Consideration is
given to nuclear tunnelling and to the optical properties of semiconductor nano-crystals. Attention then turns
to recent discoveries in single-molecule spectroscopy and to the optical properties of conducting polymers.
Finally, charge transfer in proteins and DNA will be highlighted.
Is the module suitable for study abroad students? Yes
Intended Knowledge Outcomes:
understanding of the basic principles of each of the three topics covered in the module
understanding of modern electrochemistry, including electrochemical mechanisms
understanding of relationship between structure and function of materials
knowledge of the various experimental protocols that underpin these techniques
appreciation of the methodologies use in data interpretation
understanding of electron-transfer reactions with special reference to solar energy conversion
knowledge of crystallography and microscopy, including time-dependent methods
Intended Skill Outcomes:
Subject specific or professional skills, able to:
design experiments to deduce chemical structures or properties
derive important chemical information from experimental protocols
use such information to optimise chemical systems
Cognitive or intellectual skills, able to:
critically evaluate various experimental and/or theoretical techniques
recognise the most appropriate technique to use for a particular operation
evaluate statistical data
Key skills, able to:
read critically the scientific and technical literature
write reports
describe progress and status of an experiment
Teaching and learning methods:
Method Number Length Student Hours Academic Staff
Contact Hours
Graduate Skills Framework:
Cognitive / Intellectual Skill
Information Literacy
Critical Thinking:
P - Present, A - Assessed
Data Synthesis:
Active learning : P Numeracy: P
Literacy: P
Source materials: Synthesise and Present Materials:
Use of Computer Application
Self Management
Self-awareness and Reflection P
Planning & Organisation
Goal setting & action planning: Decision Making:
Personal Enterprise
Innovation and Creativity: Initiative: P
Independence: P Adaptability: P
Problem Solving A
Budgeting:
Interaction
Communication
Oral: Foreign Languages:
Interpersonal: Written/Other:
A
Team Working
Collaboration: Relationship Building:
Leadership: Negotiation:
Peer Assessment/Review:
Application
Occupational Awareness:
Commercial Acumen
Market Awareness: Governance Awareness:
Financial Awareness: Business Planning:
Ethical Awareness: Social, Cultural & Global Awareness
Legal Awareness:
Lectures:
Seminars:
Tutorials:
Practicals:
Fieldwork:
Private Study:
24 001:00 024:00 024:00
3 001:00 003:00 003:00
0 0:00 0:00 0:00
1 001:00 001:00 001:00
Class Tests:
Group Learning:
1 001:00 001:00 001:00
0070:00
0 0:00 0:00 0:00
1 001:00 001:00 001:00
Other method(s)
Timetabling Information:
2 lectures per week and one seminar/workshop per month
Approx Student Numbers:
15
Rationale and relationship to learning outcomes:
Students acquire knowledge and understanding through lectures and by the way of research articles
available on the web. Handouts will provide additional knowledge. Students will undertake organised trips
to research labs to see the various techniques in operation and will have opportunity to talk to specialists
about these experimental protocols. Research articles will be discussed both formally and informally and
used to illustrate the formal lectures. Students will be directed to key websites where additional information
can be found in a more user-friendly manner than advanced textbooks.
Charge and Energy
Transfer Dynamics in
Molecular Systems
V May & O
Kuhn
Wiley-VCH 352729608
5
No Yes Yes
Crystallization JW Mullin Butterworth-Heinemann
Oxford, 1993
075061129
4
No Yes Yes
Molecular Electronics J Jortner &
MA Ratner
IUPAC/Blackwell Science
Ltd
063204284
2
No Yes Yes
Electrode Potentials RG Compton OU Chemistry Series 019855684
5
No Yes Yes
Electrochemical Methods AJ Bard & LR
Faulkner
John Wiley & Sons; 2nd
Edition
047104372
9
No Yes Yes
Dynamic Electrochemistry AC Fisher OU Chemistry 074925189
1
No Yes Yes
Title Author Notes ISBN Essent. Bkgrnd. Recmd.
Written Examination 120 2 40 Open book examination
Type Length
(mins)
When Set % of formal
assessment
Comment for assessment
Jointly taught with:
Reading References:
Exams:
Exams Pairing Requirements:
Other Assessment:
Total Hours : 030:00 0100:00
Other 2 30 Research Assignment (week 3) A set of three
assignments, developed around a research
topic closely related to the taught material
Other 2 30 Assignment (week 6) combination of three
separate assignments set by individual lecturer
Type When Set % of formal
assessment
Comment for assessment
Assessment rationale and relationship:
The examination assesses the students' knowledge of the principles of the subject, ability to solve problems
and to discuss critically various topics. Assignments (each worth 10%) test the ability of the student to
discuss the various techniques in terms of modern research issues.
Resits will normally be by examination only; coursework marks are carried.
Chemistry Chemistry 100
Academic Cost Centre Jacs Subject Code Subject Proportional
Split (%)
03/02/2010 Signed by Head of School(s) or nominee:
Immunisation / Allergy Screening (complete only if module is taken by non-clinical students)
Immunisation Should be offered (yes/no
Hepatitis A:
Hepatitis B:
Tetanus:
Allergy Screening:
No
No
No
No
Handbook Text:
General Notes:
Hesa Data:
Internal Resourcing:
Module Outline Form
Module code: CHY8424
Module Title: Catalyst Application and Design
Short Title: Catalyst Application and Design
10
Semester 1 credits: Semester 2 credits:
0
Semester 3 credits:
0
ECTS credits:
5.0
FHEQ Level : 7
Owning School : Chemistry
Dr Robert John Errington Lecturer 50
Dr Simon Doherty Module Leader 50
Full Name Contributor Description % Contribution
4
Support Staff Requirements:
PreRequisites :
CHY3301 Advanced Inorganic Chemistry
Code Short Title
CoRequisites :
PostRequisites :
F106 MChm Hon Chemistry (Industrial Training) Yes No No
F124 MChem Medicinal Chem (Ind Train) Yes No No
F123 MChem with Hons in Medicinal Chemistry Yes No No
F107 MChem Chemistry with Study in Europe Yes No No
5099F MSc Drug Chemistry (FT) Yes No No
F105 MChem Chemistry with study in N America Yes No No
F103 MChem with Hons in Chemistry Yes No No
5099P MSc Drug Chemistry (PT) Yes No No
Code Title Optional Compulsory Core
Other Programme Links :
Availability:
Annually
Academic Year:
Equivalent Modules :
ModuleRole(s) :
Programme Links:
Stage
2011/12 Active: Yes
Max Capacity:
999
Date:29/03/2011,08:45AM
Mode : Linear Stand alone : Not Available
Aims:
To use selected industrial processes and environmental challenges to illustrate current approaches to
catalyst development
Module Summary:
This course will discuss the importance of a number of hetereogenous processes including Fischer-Tropsch
chemistry ammonia synthesis, oxidation methanol syntheis and aspects of solid acid catalysis.
This module will also introduce the basic principles and elementary steps required to understand
homogeneous catalysis.
A range of metal catalysed processes important to the chemical industry will be investigated including
rhodium- and cobalt-catalysed hydroformylation, rhodium and ruthenium-catalysed hydrogenation, alkene
oligomerisation and polymerisation, metathesis, isomerisation reactions, palladium catalysed cross
couplings and carbonylation of alkenes, epoxidations, hydrosilylation and applications of chiral Lewis acids
to important catalytic processes such as Michael additions, hydrocyanation of aldehydes, Strecker reactions
and organozinc addition to aldehydes. The industrial relevance and importance of selected reactions will be
highlighted and discussed.
Outline of Syllabus:
Ammonia and methanol synthesis
Acid catalysts cracking and reforming of hydrocarbons.
Zeolites and polyoxometalates as selective catalysts
An introduction to the basic mechanisms required to understand homogenous catalysis,
Palladium catalysed carbonylations, cross couplings and related C-C and C-N bond forming reactions,
hydroamination and C-H activation.
Ruthenium catalysed hydrogenation and transfer hydrogenation, cobalt and rhodium catalysed
hydroformylation; an industrial perspective, acetic acid synthesis, metathesis, alkene polymerisation,
isomerisation and epoxidation, aqueous and fluorophase catalysis, tandem reactino sequences,
Lewis acid catalysis including key principles of stereochemistry, the design of Lewis acid catalysts and
applications
Is the module suitable for study abroad students? Yes
Intended Knowledge Outcomes:
understand the general principles of homogeneous and heterogeneous catalysis, including the
manufacture, activity, selectivity and operability of industrial catalysts
know about the activity patterns of metal catalysts
know about some specific examples of industrial heterogeneous catalysis and catalytic processes
know about the relationships between fundamental organometallic chemistry and developments in
homogeneous catalysis
know about recent major developments in homogenous catalysis with potential importance to the
chemical industry
appreciate current/evolving challenges in homogeneous catalysis
understand how ligand design can be used to optimise catalyst performance
understand the way in which Lewis acids can catalyse chemical reactions
Intended Skill Outcomes:
Subject specific or professional skills, able to
demonstrate how catalysts are optimized to improve activity, selectivity, operability and lifetime
rationalise how a catalyst can be optimised for a particular transformation
predict mechanisms of selected catalytic transformations and understand the concept behind cascade
reactions
rationalise the regio-, chemo- and enantioselectivity obtained in catalytic reactions
Cognitive or intellectual skills:
understanding of mechanistic principles
design of catalytic transformations
Key skills:
problem solving skills
understanding scientific literature
Teaching and learning methods:
Method Number Length Student Hours Academic Staff
Contact Hours
Lectures:
Seminars:
Tutorials:
Practicals:
Fieldwork:
Private Study:
24 001:00 024:00 024:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Class Tests:
Group Learning:
0 0:00 0:00 0:00
0076:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Other method(s)
Total Hours : 024:00 0100:00
Graduate Skills Framework:
Cognitive / Intellectual Skill
Information Literacy
Critical Thinking:
P - Present, A - Assessed
Data Synthesis:
Active learning : P Numeracy: A
Literacy: P
Source materials: Synthesise and Present Materials:
Use of Computer Application
Self Management
Self-awareness and Reflection P
Planning & Organisation
Goal setting & action planning: Decision Making:
Personal Enterprise
Innovation and Creativity: Initiative:
Independence: P Adaptability:
Problem Solving
Budgeting:
Interaction
Communication
Oral: Foreign Languages:
Interpersonal: Written/Other:
A
Team Working
Collaboration: Relationship Building:
Leadership: Negotiation:
Peer Assessment/Review:
Application
Occupational Awareness:
Commercial Acumen
Market Awareness: Governance Awareness:
Financial Awareness: Business Planning:
Ethical Awareness: Social, Cultural & Global Awareness
Legal Awareness:
Timetabling Information:
2 lectures per week
Approx Student Numbers:
20-25
Rationale and relationship to learning outcomes:
Much of the key material is conceptual and is suited to delivery via lectures. The problem solving sessions
are designed to complement the lectures and provide the students with an increased appreciation of the
topics involved
Applied Homogeneous
Catalysis with
Organometallic
Compounds
B. Cornils,
W. Hermann
2005 352729288
8
No No Yes
Homogeneous Catalysis
Understanding the Art
P. W. N. van
Leeuwen
2004 140203176
9
Yes No No
Title Author Notes ISBN Essent. Bkgrnd. Recmd.
Written Examination 120 1 100
Type Length
(mins)
When Set % of formal
assessment
Comment for assessment
Assessment rationale and relationship:
The examination will assess the student's knowledge and understanding of the principles, development and
practice of homogeneous and heterogeneous catalysis
Resits will normally be by examination only.
Chemistry Chemistry 100
Academic Cost Centre Jacs Subject Code Subject Proportional
Split (%)
Chemistry 100
Contributing School FTE Proportional split (%)
01/01/2005 Signed by Head of School(s) or nominee:
Immunisation / Allergy Screening (complete only if module is taken by non-clinical students)
Immunisation Should be offered (yes/no
Hepatitis A:
Hepatitis B:
No
No
Jointly taught with:
Reading References:
Exams:
Exams Pairing Requirements:
Other Assessment:
Hesa Data:
Internal Resourcing:
Tetanus:
Allergy Screening:
No
No
Handbook Text:
General Notes:
Module Outline Form
Module code: CHY8425
Module Title: Further Inorganic Chemistry
Short Title: Further Inorganic Chemistry
0
Semester 1 credits: Semester 2 credits:
10
Semester 3 credits:
0
ECTS credits:
5.0
FHEQ Level : 7
Owning School : Chemistry
Dr Robert John Errington Lecturer 33
Prof. Andrew Houlton Lecturer 33
Dr Keith James Izod Module Leader 34
Full Name Contributor Description % Contribution
4
Support Staff Requirements:
N/A 0
Other Institution(s): Proportion of teaching %
PreRequisites :
CHY3301 Advanced Inorganic Chemistry
CHY3101 Advanced Organic Chemistry
Code Short Title
CoRequisites :
PostRequisites :
F124 MChem Medicinal Chem (Ind Train) Yes No No
F107 MChem Chemistry with Study in Europe Yes No No
F123 MChem with Hons in Medicinal Chemistry Yes No No
F106 MChm Hon Chemistry (Industrial Training) Yes No No
F103 MChem with Hons in Chemistry Yes No No
F105 MChem Chemistry with study in N America Yes No No
Code Title Optional Compulsory Core
Other Programme Links :
Academic Year:
Equivalent Modules :
ModuleRole(s) :
Programme Links:
Stage
2011/12 Active: Yes
Max Capacity:
999
Date:29/03/2011,08:46AM
Mode : Linear Stand alone : Not Available
Availability:
Annually
Aims:
To present a series of short courses on advanced topics in contemporary inorganic chemistry; to show how
fundamental aspects of inorganic chemistry are being used to develop new concepts in chemistry and
applied in modern chemical industry.
Module Summary:
This module shows how concepts learnt in earlier stages of the students studies are used in modern
inorganic chemistry with an emphasis on contemporary research topics. The module will comprise 3
different, but related, aspects of inorganic chemistry
Outline of Syllabus:
The module will comprise 3 of the topics shown below. Students will be informed of the composition of the
module at pre-registration.
Lanthanide Chemistry. The elements, common coordination numbers, oxidation states, geometries and
reactivites.
Electronic Spectroscopy in Metal Complexes. The shapes and positions of peaks in the electronic spectra
of transition metal complexes. nterpreting electronic spectra.
norganic Materials.
Structural Methods in norganic Chemistry. Applications and limitations of techniques such as Mossbauer,
EPR spectroscopies, electron diffraction etc.
Organometallic Chemistry Reaction Mechanisms. The fundamental mechanisms associated with
organometallic compounds and their application in understanding complex multistep reactions.
Is the module suitable for study abroad students? Yes
Intended Knowledge Outcomes:
understand the fundamental chemistry of the f-block elements
understand the shapes and intensities of electronic spectra of complexes
be aware of the ways in which inorganic compounds can be designed to give rise to commercially
important new materials
be aware of the application of some of the less common spectroscopic and structural methods used to
analyse inorganic compounds
understand the reactivity of organometallic compounds by application of mechanistic principles and
predict the reactivity of new complexes
Intended Skill Outcomes:
Subject specific or professional skills, able to:
interpret electronic spectra of metal complexes
apply specialist techniques to elucidate the structure and bonding in inorganic compounds
use simple mechanistic principles to understand and predict the outcome of complicated organometallic
transformations.
predict the mechanism and products of the reactions of organometallic compounds
Graduate Skills Framework:
Cognitive / Intellectual Skill
Information Literacy
Critical Thinking:
P - Present, A - Assessed
Data Synthesis:
Active learning : P Numeracy: A
Literacy: P
Source materials: Synthesise and Present Materials:
Use of Computer Application
Self Management
Self-awareness and Reflection P
Teaching and learning methods:
Method Number Length Student Hours Academic Staff
Contact Hours
Lectures:
Seminars:
Tutorials:
Practicals:
Fieldwork:
Private Study:
24 001:00 024:00 024:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Class Tests:
Group Learning:
0 0:00 0:00 0:00
0076:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Other method(s)
Timetabling Information:
3 lectures per week. Data projection required.
Approx Student Numbers:
12
Rationale and relationship to learning outcomes:
Jointly taught with:
Total Hours : 024:00 0100:00
Planning & Organisation
Goal setting & action planning: Decision Making:
Personal Enterprise
Innovation and Creativity: Initiative: P
Independence: P Adaptability: P
Problem Solving A
Budgeting:
Interaction
Communication
Oral: Foreign Languages:
Interpersonal:
P
Written/Other:
A
Team Working
Collaboration: Relationship Building:
Leadership: Negotiation:
Peer Assessment/Review:
Application
Occupational Awareness:
Commercial Acumen
Market Awareness: Governance Awareness:
Financial Awareness: Business Planning:
Ethical Awareness: Social, Cultural & Global Awareness
Legal Awareness:
This module presents a diverse range of topics in inorganic chemistry. Some of the topics build on modules
presented at Stage 3 but take the topic to a more advanced level. Others are topics to which the student
has never been exposed before. All of the topics represent contemporary research areas in inorganic
chemistry and are suitable for advanced students wanting to specialise in inorganic (or allied) chemistry.
Students will acquire their knowledge and understanding through lectures and problem sheets.
Written Examination 120 2 100
Type Length
(mins)
When Set % of formal
assessment
Comment for assessment
Assessment rationale and relationship:
The examination will assess the student's knowledge and understanding of selected topics in inorganic
chemistry.
Resits will normally be by examination only.
Chemistry Chemistry 100
Academic Cost Centre Jacs Subject Code Subject Proportional
Split (%)
01/01/2005 Signed by Head of School(s) or nominee:
Immunisation / Allergy Screening (complete only if module is taken by non-clinical students)
Immunisation Should be offered (yes/no
Hepatitis A:
Hepatitis B:
Tetanus:
Allergy Screening:
No
No
No
No
Handbook Text:
General Notes:
Reading References:
Exams:
Exams Pairing Requirements:
Other Assessment:
Hesa Data:
Internal Resourcing:
Module Outline Form
Module code: CHY8426
Module Title: Functional Molecules
Short Title: Functional Molecules
10
Semester 1 credits: Semester 2 credits:
0
Semester 3 credits:
0
ECTS credits:
5.0
FHEQ Level : 7
Owning School : Chemistry
Dr Andrew Christopher Benniston Lecturer 50
Prof. Anthony Harriman Module Leader 50
Full Name Contributor Description % Contribution
4
Support Staff Requirements:
N/A 0
Other Institution(s): Proportion of teaching %
PreRequisites :
CHY3001 Advanced Practical Chemistry
Code Short Title
CoRequisites :
PostRequisites :
F106 MChm Hon Chemistry (Industrial Training) Yes No No
F107 MChem Chemistry with Study in Europe Yes No No
F123 MChem with Hons in Medicinal Chemistry Yes No No
F105 MChem Chemistry with study in N America Yes No No
F103 MChem with Hons in Chemistry Yes No No
Code Title Optional Compulsory Core
Other Programme Links :
Availability:
Annually
Academic Year:
Equivalent Modules :
ModuleRole(s) :
Programme Links:
Stage
2011/12 Active: Yes
Max Capacity:
999
Date:29/03/2011,08:47AM
Mode : Linear Stand alone : Not Available
Aims:
To introduce the basic principles involved in the design, synthesis and application of molecular systems
used for a variety of purposes and to develop new materials
Module Summary:
The course is intended to introduce students to the concept of designing a molecular system for a particular
purpose, e.g. the quantitative detection of glucose in blood. This will be followed by a careful consideration
of how to synthesise an appropriate molecule equipped with all the necessary functions to carry out its
intended purpose. The final component deals with how to test the system under operating conditions.
Outline of Syllabus:
ntroduction
Design of luminescent sensors for analytical protocols
Novel anti-cancer drugs for eradication of tumours
A new generation of conducting polymers and light-emitting diodes
Storing solar energy
Magnetic resonance imaging of the brain
How to build a molecular computer
Is the module suitable for study abroad students? Yes
Intended Knowledge Outcomes:
To understand the basic principles of designing molecular systems for predetermined applications
To explain how to synthesize a suitable molecule that is fully compatible with the intended application
To demonstrate how to evaluate and test the molecule under operating conditions
Intended Skill Outcomes:
Subject specific or professional skills, able to:
apply the principles of photochemistry to unseen problems.
Key skills, able to:
read critically the scientific and technical literature.
write reports
Graduate Skills Framework:
Cognitive / Intellectual Skill
Information Literacy
P Critical Thinking:
P - Present, A - Assessed
P Data Synthesis:
Active learning : P Numeracy: A
Literacy: P
Source materials: Synthesise and Present Materials: A
Use of Computer Application A
Self Management
Self-awareness and Reflection P
Planning & Organisation
Goal setting & action planning: Decision Making:
Personal Enterprise
Innovation and Creativity: P Initiative: P
Independence: P Adaptability:
Problem Solving A
Budgeting:
Teaching and learning methods:
Method Number Length Student Hours Academic Staff
Contact Hours
Lectures:
Seminars:
Tutorials:
Practicals:
Fieldwork:
Private Study:
24 001:00 024:00 024:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Class Tests:
Group Learning:
0 0:00 0:00 0:00
0076:00
0 0:00 0:00 0:00
0 0:00 0:00 0:00
Other method(s)
Timetabling Information:
2 lectures per week
Approx Student Numbers:
15
Rationale and relationship to learning outcomes:
Students acquire knowledge and understanding through lectures and problem sheets. Fundamentals will be
built upon rapidly to take the students from basic ideas to the design of a suitable prototype and its
subsequent synthesis and testing.
CHY8826 Functional Molecules 1
Code Short Title Semester
Jointly taught with:
Reading References:
Total Hours : 024:00 0100:00
Interaction
Communication
Oral: Foreign Languages:
Interpersonal:
P
Written/Other:
A
Team Working
Collaboration:
P
Relationship Building:
P
Leadership: Negotiation:
Peer Assessment/Review:
Application
Occupational Awareness:
Commercial Acumen
Market Awareness: Governance Awareness:
Financial Awareness: Business Planning:
Ethical Awareness: Social, Cultural & Global Awareness
Legal Awareness:
Modern methods of
organic synthesis
W Carruthers
Coldham
052177830
1
No No Yes
Essentials of molecular
Photochemistry
Blackwell Scientific
Publications
1990
A Gilbert
J Baggot
063202429
1
No No Yes
Molecular design and
bioorganic catalysis
C S Wilcox
A D Hamilton
079234024
8
No No Yes
How to tackle organic
syntheses
O Meth-Cohn No No Yes
Chemical Sensors and
Biosensors
B R Eggins 047189914
3
No Yes No
Title Author Notes ISBN Essent. Bkgrnd. Recmd.
Written Examination 105 1 50
Type Length
(mins)
When Set % of formal
assessment
Comment for assessment
Coursework 1 50
Type When Set % of formal
assessment
Comment for assessment
Assessment rationale and relationship:
The exam will cover all aspects of the course, and will assess the ability of the students to discriminate
between various theoretical approaches. The assignment will involve the design of selected prototypes and
a consideration of their synthesis and testing.
Resits will normally be by examination only; coursework marks are carried.
For resits taken at the next normal occasion, coursework components will be included and may be retaken
by internal candidates.
CHY8826 Functional Molecules
Code Short Title
Chemistry Physical Chemistry 100
Academic Cost Centre Jacs Subject Code Subject Proportional
Split (%)
01/01/2005 Signed by Head of School(s) or nominee:
Immunisation / Allergy Screening (complete only if module is taken by non-clinical students)
Immunisation Should be offered (yes/no
Hepatitis A:
Hepatitis B:
Tetanus:
Allergy Screening:
No
No
No
No
Exams:
Exams Pairing Requirements:
Other Assessment:
Hesa Data:
Internal Resourcing:
Handbook Text:
General Notes: