UNIVERSITY OF PUNE

UNDER FACULTY OF PHARMACEUTICAL SCIENCES SYLLABI, MODEL QUESTION PAPER

1. PHARMACEUTICS 2. PHARMACEUTICAL CHEMISTRY 3. PHARMACOLOGY 4. PHARMACOGNOSY ANNEXURE-II
Syllabus for Ph. D Admission Entrance Test (Paper-II) in Pharmaceutical Sciences 1. Pharmaceutics (PY-01): Development, manufacturing standards, Q.C. limits of Pharmaceutical products and medical devices, labeling of Pharmaceutical products, and the storage as per the pharmacopoeial and other regulatory requirements. Storage of different dosage forms and new drug delivery systems. Biopharmaceutics and Pharmacokinetics and their importance in formulation. Formulation and preparation of cosmetics lipstick, shampoo, creams, nail preparations and dentifrices, Pharmaceutical calculations. 2. Pharmaceutical & Medicinal Chemistry(PY-02): Structure, nomenclature, classification, synthesis, SAR and metabolism of the following category of drugs, which are official in Indian Pharmacopoeia and British Pharmacopoeia. Introduction to drug design. Brief introduction to QSAR, Stereochemistry of drug molecules. Hypnotics & Sedatives, Analgesics, NSAIDS. Neuroleptics, Antidepressants, Anxiolytics, Anticonvulsants, Antihistaminics, Local Anaesthetics, Cardiovascular drugs Antianginal agents, Vasodilator, Adrenergic and Cholinergic drugs, Cardiotonic agents, Diuretics, Antihypertensive drugs, antihyperglycemic agents, Antilipidemic agents, Coagulants, Anticoagulants, Antiplatelet aggregating agents. Chemotherapeutic agents Antibiotics, Antibacterials, Sulphadrugs. Antiprotozoal drugs, Antiviral, Antitubercular, Antimalarial, Anticancer, Antiamoebic drugs. Diagnostic agents. Preparation, storage and uses of official Radiopharmaceuticals, Vitamins and Hormones. Eicosanoids and their applications. 3. Pharmacology (PY-03): General pharmacology, Pharmacokinetics, Pharmacodynamics and Toxicology. OECD guidelines, Drug interaction. Pharmacology of drugs acting on central nervous system, Cardiovascular system, Autonomic nervous system, Gastrointestinal system and Respiratory system. Pharmacology of Autocoids, Hormones, Hormone antagonists, chemotherapeutic agents including anticancer drugs. Bioassays, Immuno-pharmacology. Drugs acting on the blood and blood forming organs. Drugs acting on the renal system. Pre-Clinical and Clinical testing of drugs. 4. Pharmacognosy (PY-04): Pharmacognosy and Phytochemistry, Chemistry, tests, isolation, characterization and estimation of phytopharmaceuticals belonging to the group of Alkaloids, Glycosides, Terpenoids, Steroids, Bioflavanoids, Purines, Guggul lipids. Pharmacognosy of crude drugs that contain the above constituents. Standardization of raw materials and herbal products. WHO guidelines for Standardisation. Quantitative microscopy including modern techniques used for evaluation. Biotechnological principles and techniques for plant development, Tissue culture. 9 Common syllabus for all four branches of Pharmaceutical Sciences 1. Drug Regulatory Affairs: Drugs and Cosmetics Act and rules with respect to manufacture

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sales and storage. Pharmacy Act, Pharmaceutical ethics, Indian Patent Act 1970,its amendments, concepts of IPR, criteria for granting patents and filing a Indian patent, PCT, Patent infringement. INDA/NDA/ANDA filing. Para-I, II, III, IV filing Hatch-Waxman amendments. Introduction to Patent Search. 2. Pharmaceutical Analysis: Principles, instrumentation and applications of the following: Absorption spectroscopy (UV, visible and IR), Fluorimetry, Flame Emission, Atomic Emission, Electro analytical Techniques. Pharmacopoeial assays. Principles of NMR, ESR, Mass spectroscopy, X-ray diffraction analysis and different chromatographic methods, Thermal Techniques. 3. Pharmaceutical Biochemistry & Microbiology: Biochemical role of hormones, Vitamins, Enzymes, Nucleic acids, Bioenergetics, General principles of immunology. Metabolism of carbohydrates, lipids, proteins, Methods to determine, kidney & liver function, Lipid tests and Immunological Assays. Principles and methods of Pharmacopoeial microbiological assays. Methods of preparation of official sera and vaccines. Serological and diagnostics tests. Applications of microorganisms in Bio-conversions and in Pharmaceutical industry. 4. Clinical Pharmacy: Therapeutic Drug Monitoring, (Dosage regimen in Pregnancy and Lactation, Pediatrics and Geriatrics). Renal and Hepatic Impairment. Drug-Drug interactions and Drug-Food interactions, Adverse Drug reactions. Medication History, Interview and Patient counseling. Statistical Analysis: Design of Experiments, Optimization techniques, Correlation of data, Parametric and nonparametric tests, Statistical interpretations, Hypothesis testing, Level of significance. ---10

ANNEXURE-III
Model Question Paper for Ph. D Admission Entrance Test (Paper-II) in Pharmaceutical Sciences -----------------------------------------------------------------------------------------------------------------University of Pune Paper code Faculty: Pharmaceutical Sciences Subject & Subject code: Pharmaceutics (PY01) Date: Time: (Max. time for section-I:30 min.) ---------------------------------------------------------------------------------------------------------------SECTION-I Q. 1.0: Solve all following sub-questions (One mark each) 20 marks 1.1. Molarity of simple syrup USP is A) 5.8 B) 8.5 C) 4.7 D) 85 1.2. Complete mixing of magnesium stearate with tablet granules will A) Decrease the crushing strength of tablets B) Increase tablet hardness C) Increase tablet dissolution D) Increase tablet disintegration 1.3. Rate of elimination of drug from body is, if follows zero order kinetics, then it A) is constant B) Depends on plasma concentration C) Depends on type of metabolic pathway D) None of the above 1.4. 2, 2 , 2, 2 - {[4, 8 dipiperidino (5, 4 -D) pyrimidino - 2, 6 - diyl}dinitrilo} tetraethanol is A) Disopyramide B) Dipyridamole C) Dicyclomine D) Disulfiram 1.5. The parent nucleus present in the structure aconitine is A) Benzazulene B) Imidazole C) Indole D) Piperidine 11 1.6. The malonic ester synthesis of barbital yields which of the following main form? A) -form B) -form C) -form D) -form 1.7. Following receptors are membrane proteins, except a) Receptors for fast neurotransmitters coupled directly to an ion channel

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b) Receptors for many hormones and slow transmitters, coupled to effectors System c) Receptors for insulin and various growth factors, which are directly linked to Tyrosine kinase. d) Receptors for steroid hormone 1.8. Opoid receptors act via a) Opening of potassium channels b) Inhibition of calcium channels c) Both (a) and (b) d) Opening of sodium channels 1.9. _1- receptors are coupled with_______ G protein. a) Gs b) Gi c) Gq d) Go 1.10. The apparatus recommended in BP for the hydrodistillation of volatile oil is known as ____________ A) Soxhlet apparatus B) Clavengers apparatus C) Supercritical fluid extractor D) Enfleurage 1.11. The amount of volatile oil in volatile oil containing plant is determined by using A) Soxhlet apparatus B) Karl-Fischer apparatus C) Clevenger apparatus D) Wildman trap flask 1.12. The chemicals which are coloured red when diluted tincture of alkane stains the cell walls are A) Peptidoglycan, mucilage B) Cutin, suberin C) Lignin, protein D) Starch, calcium oxalate 1.13. The C=O (aldehydic) bond shows characteristic stretching band at about A) 1730 - 1700 cm-1 B) 2830 - 2695 cm-1 C) 1060 - 1275 cm-1 D) 1000 - 1200 cm-1 12 1.14. A Ramachandran plot shows __________ (A) The amino acid residues that have the greatest degrees of rotational freedom. (B) The sterically allowed rotational angles between the side chain groups in a peptide and the peptide backbone. (C) The sterically limited rotational angles (domains) where phi and psi are allowed in the protein backbone. (D) The angles that are allowed about the bonds connecting the amide nitrogen in a peptide bond. 1.15. The neurotransmitter derived from tryptophan is a. GABA b. Epinephrine c. Serotonin d. nor-epinephrine 1.16. Sterilization indicator used for ethylene oxide sterilization is A) Bacillus osteoarthropathies B) Bacillus pumilus C) Bacillus subtilis var. niger D) Pseudomonas dimunata 1.17. If a drug is not labeled in a prescribed manner, it is deemed to be .. A) Spurious B) Adulterated C) Substandard D) Misbranded 1.18. The patient suffering from complex partial seizures was treated for six months with carbamazepine, but recently, has been experiencing breakthrough seizures on a more frequent basis. You are considering adding a second drug to this patient s anti-seizure regimen. Which one of the following is least likely to have a pharmacokinetic interaction with carbamazepine A) Topiramate B) Tiagabine C) Levetiracetam D) Lamotrigine 1.19. The chi-square distribution always has . A) Positive values B) Negative values C) Positive and Negative Values D) None of the above 1.20. The paired T- test is used to compare . A) Median B) Standard deviation C) Mean D) None of the above

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