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my understanding of bioinformatics and computational biologyfollows the NIH definitions listed below: Bioinformatics: Research. genetics.edu/ Bioinformatics = Hot Field Smart Money: #1 among next hot jobs http://smartmoney. including those to acquire. molecular biology and mathematics. mathematical modeling and computational simulation techniques to the study of biological.kwing. I'll throw my two cents in.html Image Source: http://ccb.000 results! Inthe past few years. analyze.Bioinformatics can lead to important discoveries as well as help companies save time andmoney in the long run.htm So why is bioinformatics a hot field? One answer to this question is that it is tied to thehuman genome project which has generated a lot of popular interest. biochemestry. involvingresearchers from different areas of specialty. Others have offered various opinions into these definitions as well:http://kbrin. behavioral or health data.Introduction to Bioinformatics Lecture 1: Overview of Bioinformatics and Molecular BiologyWhat is Bioinformatics? Defining the terms bioinformatics and computational biology is not necessarily aneasy task. One of the biggest reasons for bioinformatics being a hot field is the old supplyand demand . behavioral. while for others.louisville. archive. The goal of these two fields is as follows: • Bioinformatics: Typically refers to the field concerned with the collectionand storage of biological information. there needs to be methods to manage large amountsof data.Computational biology and bioinformatics are multidisciplinary fields. physics. Computational Biology: The development and application of data-analytical and theoreticalmethods. or visualize such data. All matters concerned with biologicaldatabases are considered bioinformatics. organize. computer science. there isa great distinction.wustl. what does it all mean? That’s where bioinformatics steps in.edu/~rouchka/definition.In this respect. based on what my experience hasbeen to the consensus use of these two terms.com/consumer/index. • Computational biology: Refers to the aspect of developing algorithmsand statistical models necessary to analyze biological data through the aidof computers. and social systems.cfm?story=working-june02 Business Week: Among 50 Masters of Innovation http://www. medical. or application of computational tools and approachesfor expanding the use of biological. Various advancesin molecular biology techniques (such as genome sequencing and microarrays) has led toa large amount of data that needs to be analyzed.businessweek. For some.store. including (but in no means limitedto) statistics. In addition. as evidenced by multiple definitions available over the web. Now that we are close to having thehuman genome finished. the terms bioinformatics and computationalbiology have become completely interchangeable terms.com/bw50/content/mar2001/bf20010323_198. a greater confusion into these twoterms has prevailed. as the areas have grown. A recentgoogle search for "definition of bioinformatics" returned over 43. development.

uk/microarray/ biology_intro. One copy of each pair is inherited from each parent. such as bacteria and baker’s yeast are composed of only asingle cell (i.ebi.ac. Karyotype showing the 23 pairs of human chromosomes.htm There are two types of organisms: eukaryotes and prokaryotes.html Image source: www. guanine (G) .edu/WSSP/StudentScholars/Session8/Session8. let’s make surethe basics are covered. cytosine (C).uk/microarray/biology_intro.ebi. Inside the nucleus are thechromosomes. mitochondria.which is separated from the rest of the cell by a membrane. including plants and animals.html )In order to be a good computational biologist. eukaryotic cells contain membrane bound organelles with various functions. Structure of an animal cell.th/Genome/ whatGenome.e. Other organisms are made up of many differentcells (i.html DNA Deoxyribonucleic Acid (DNA) is the basis for the building blocks encoding theinformation of life. Inaddition. Introduction to Molecular Biology (For a good overview of this topic. For humans.ac.including centrioles. where all of the genetic information for the organism is stored. But first.or. There just are too few people adequately trained in both biology andcomputer science to solve the problems that biologists need to have solved. or bases: adenosine (A). as well as one pair of sex chromosomes.Contained within the nucleus are one or several long double stranded DNA moleculesorganized as chromosomes. Humans have about 320 different cell types.adage. Image source: www. etc. A single stranded DNA molecule.e. is a chain of small molecules called nucleotides.biotec. Each cell is in itself a complex system enclosed in amembrane. There are two different types of biologicalsequences studied in this class: DNA/RNA and amino acids. they are multicellular). the human body is composed of around 60trillion cells.Prokaryotes are single cellular organisms (but not all single-celled organisms are prokaryotes!)So what is the difference between the two types of cells? A eukaryotic cell has a nucleus. there are 22 pairs of autosomes. Image source: http://avery. lysosomes. For instance. Some organisms. Many interesting problems arise out of sequence analysis. Prokaryotes (such as bacteria) are smaller than eukaryotic cells and have simpler structure. There are four differentnucleotides. called a polynucleotide or oligomer . it is important to understand theterminology and basic processes behind the biological problems. each having a different type of function or structural property. they are unicellular).rutgers. please read:http://www. Eukaryotes (or as BruceRoe from the University of Oklahoma calls them the “You and I” Karyotes) representmost of the organisms which we can see. Often these cells are too smallto be seen with the naked eye. ribosomes. Cells Every organism is made up of tiny structures called cells.

and thymine (T). When DNA is double-stranded. and C binds to G. the following is a polynucleotide: 5’ G → T → A → A → A → G → T → C → C → C → G → T → T → A → G → C3’ DNA can be either single-stranded or double stranded. the ends of the polynucleotide are different. For the polynucleotide given above. the double-stranded polynucleotide is as follows: 5’ G → T → .The bases can be separated into two different types: purines (A and G) and pyrimidines(C and T). This name is derivedfrom the fact that the directionality of this second strand runs in the opposite direction asthe first. The general convention is to label the codingstrand from 5’ to 3’ (left to right). However. and the fact that the bases in the second strand are complementary to the bases inthe first. Complementary bases are determined by which pairs of nucleotides can form bonds between them. In the case of DNA.Stringing together a simple alphabet of four characters together we can get enoughinformation to create a complex organism! Different nucleotides can be strung together to form a polynucleotide.the second strand is referred to as the reverse complement strand. A binds to T. The ends of the polynucleotide are marked either 3’ or 5’. The difference between purines and pyrimidines is in the base structure. For instance. meaningthat each polynucleotide sequence will have a directionality.

A → A → A → G → T → C → C → C → G → T → T → A → G → C3’ | | | | | | | | | | | | | | | | 3’C ← A ← T ← T ← T ← C ← A ← G ← G ← G ← C ← A ← A ← T ← C ← G5’ .

com/uherou> nice book reply06 / 09 / 2011 . Crick and Franklin.genecrc.scribd.com/santosh_divya_1> Santosh Divya <http://www.scribd.scribd.com/shantiabrookie> shantiabrookie <http://www.scribd.scribd.org/site/ lc/lc2b.com/login> to leave a comment. RNA can be found as double-stranded or single-stranded.com/econ_nutsugah> Emmanuel Con-Nutsugah <http://www.com/events/2007659594?user_id=9073643-shantiabrookie> <http://www.RNA folding will be discussed in detail during a later class period.scribd. there appear to be two types of grooves: A larger one.com/events/2017032187?user_id=133485705-santosh-divya> <http://www. Submit Characters: 400 <http://www.htm Note that in this image.scribd. In addition. thereare roughly 10. You must be logged in <http://www.scribd. and can also be part of ahybrid helix where one strand is an RNA strand and the other is a DNA strand.scribd.com/shantiabrookie> very nice reply03 / 12 / 2012 <http://www. an alternative base uracil (U) is found inRNA.Two complementary polynucleotide chains form a stable structure known as the DNAdouble helix. RNA Ribonucleic Acid (RNA) is similar to DNA in the fact that it is constructed fromnucleotides.Image source: www.scribd. This spring represents the 50 th anniversary of the discovery of the doublehelix structure of DNA by Watson.com/uherou> Uwizeye Herou <http://www.com/econ_nutsugah> thnx bt i can seem to download this file reply01 / 14 / 2012 <http://www. which iscalled the major groove and a smaller one.5 base pairs in one complete turn of the helix. However. known as the minor groove.scribd. instead of thymine (T).com/santosh_divya_1> nice reply03 / 20 / 2012 <http://www. RNA isgenerally found as a single stranded molecule that may form a secondary structure or tertiary structures due to the complementary bases between parts of the same strand. DNA double helix structure .scribd.com/events/1957562197?user_id=112345244-emmanuel-con-nutsugah > <http://www. RNA is important in of 232 Leave a Comment Comment must not be empty.

scribd.scribd.com/marmiw> Marmi Nancy Wei <http://www.com/rajesh_sahu_1> Rajesh Kumar Sahu <http://www.com/login> to leave a comment.com/rajesh_sahu_1> bio informatics reply05 / 24 / 2010 <http://www.com/events/242625613?user_id=76377581-marmi-nancy-wei> <http://www.com/events/178037124?user_id=40240272-minesh-jethva> <http://www.com/events/260580205?user_id=79979870-uwizeye-herou> <http://www.scribd.com/jminesh> Minesh Jethva <http://www..com/pablasarabjot> Uploaded by pablasarabjot <http://www.com/tag/Science-Biology?l=1> bioinformatics <http://www.<http://www.scribd. complete notes on Bioinformatics this is a pdf document with complete notes on bioinformatics for students.com/tag/Science-Biology?l=1> (fewer <#>) Flag document for inapproriate content This is a private document.scribd.com/jminesh> thanx for share reply03 / 11 / 2011 <http://www.scribd.com/events/31740222?user_id=27989511-rajesh-kumar-sahu> <http://www.scribd.scribd.scribd.com/marmiw> Thank you very much!! reply05 / 23 / 2011 <http://www.scribd.scribd.com/tag/bioinformatics?l=1> Science-Biology <http://www.scribd.scribd.scribd.scribd./ Rating: (55 Ratings) Upload Date: 03/25/2007 Copyright: Attribution Non-commercial Tags: bioinformatics <http://www.540 Reads/ Info and Rating Category: /Uncategorized.scribd.scribd. You must be logged in <http://www. Submit Characters: .com/events/20687676?user_id=20788707-naveenbt> Show More Comment must not be empty.com/naveenbt> this is very usefull thanks a lot reply12 / 24 / 2009 <http://www.scribd..com/pablasarabjot> . </static/help?type=private> <http://www.com/naveenbt> naveenbt <http://www.scribd. Download or Print /54.com/tag/bioinformatics?l=1> Science-Biology <http://www.scribd.

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