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. (H5N1)
( Fowl plague ) A
(H5N1)
(H9N2)
H9N2
(H5N1)
(H7N7)
83
(H5N1)
Orthomyxoviridae
A A, B, C.
C B
.
Subtypes A
(N) (H)
(N) (H)
(H5N7). N7 H5
(H5N7 A (H4N9).
B A
Wisconsin A H,N
H8N4
:A/turkey/Wisconsin/1/68/H8N4
A/Chicken/Scotland/59/H5N1
A/Turkey/Ontario/7732/66/H5N6
A (H5N2)
Low (H7N1)
pathogenic form
H5N1
H5N3
H5N1 ,
:-
1-
closed system
cariar
.
2-
3-
4.
5-
1-
2 :
3-
4-
.
. 5. 6 7-
. 8. 9 10-
) .
H5
H9 H7
.
:-
. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10-
:
Low pathogenic form
Viremia
Endothelial cells
.
A Free-ranging
.
.
,
% .
Guinea fowl
.
. Sinusitis
A
14 A
:
( ELISA ) . -
. 2-
H & N . 3-
Tamiflu Oseltamivir
Nature
Nature H5N1
Relenza . Zanamivir
Neuraminidase inhibitors .Neuraminidase (N)
rimantadine
.
:
:
1-
. 2-
3-
. A
4-
pH)
).
5-
6-
H N
:-
.
.
.
.
:
Paramyxovirus 1-
PMV-1
120-300 2-
RNA 3-
Hemagglutinin .
hemagglutination 4-
ha
: h1
hemolysin 5-
6-
7-
.
.
8-
..
9-
bpl 10 -
. 11-
doyle form 1-
3- baudette form
4- hitchener form
. 5- lancaster
:-
:-
.
:
:-
mean death
time mdt .
icpi plindex
ivpi .
:-
:-
lentogenic ) (
.
mesogentic strian : (
velogenic strain (
:neurotropic velogenic ndv 1-
.
pneumotropic velogenic ndv 2-
:- 3:-
:-
. ,
...
. ...
...
.
:
:
1.
2-
3-
4-
...
6-
:
1-
.
2-
3-
4-
:
peracute
...
1-
2-
proventriculus 3-
coecal
toncil
mesentry
5-
. crd
. 6-
7-
:
:
1-
. 2-
. 3 4-
5-
6-
7-
: 8-
9-
: -
. 1 2-
h.a
.
(
.
(
.
. 3 4-
5-
...
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