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ABCDs resuscitation :
A ==== Airway
B ==== Breathing
C ==== Circulation
D ====drug induced C.N.S Depression
Airway ===A
Causes of obstruction الحل
#Secretions===Suction of secretions
#Posterior displacement of the tongue===pull tongue
using tongue depressor or support jaw (head tilt chin left
maneuver)
#Foreign body e,g artificial teeth=== Remove FB
# Insert endotracheal tube (cuffed in comatosed
patient)V.I.P.
# Tracheostomy (not need definition)
B=== Breathing (Maintain respiration):
*Oxygen therapy ==Oronasal mask (Carbogen5%CO2
,95%O2)
*Artificial respiration== Mechanical ventilation If too slow
respiration i.e no chest movement or paralysis of resp.
muscles
C===circulation
Seizures(convulsions )
Management:
#airway must be kept patent+O2
# Diazepam (valium)of choice
#in status epilepticus phenytoin or Phenobarbital
Eye decontamination
In corrosives: with normal saline for at least 15-20 minute.
DONOT USE NEUTRALIZING SUBSTANCE (heat release)
Skin decontamination
1. For corrosives: use water or saline for 10-15 minute.
2. for other toxic substances: use cold water then
wash with soap.
3. Some chemicals require special TTT such as:
*Lime & cement → ttt like alkali burn
*Flammable metals →remove the large
particles & cover the surface with mineral oil.
*Phenols (cresols) → Polyethylene.
*White phosphorus →use copper sulfate
solution.(Oxidizing agent)
GIT Decontamination
a) Emesis
b) Gastric lavage
c) Activated charcoal
d) Cathartics
e) Whole-Bowel irrigation
f ) Surgical decontamination
g) Local antidotes
a)Emesis
Indications :
-Patient: alert (intact gag reflex).
-Time of ingestion: not more than 4-6 hours
-Poison: not adsorbed by activated charcoal.
- Sustained release or enteric-coated tablets or big lumps.
Contraindications:
-Patient: absent or impaired gag reflex, heart disease,
gastric ulcers , pregnancy,….
- Time of ingestion: more than 4-6 h after ingestion
- Poison: corrosives, sharp solid objects, drugs causing
convulsions, volatile hydrocarbons (kerosine).
b)Gastric lavage
Principle :
Insert tube into stomach ,washing it with water or
harmless solvent to remove unabsorbed poison
Indications :
1- After ingestion as soon as possible
2- Useful for as long as 3hrs after ingeastion
3- If delayed gastric emptying lavage useful for 12hrs
4- Considered only if patient ingested life threatening
amount of toxic substance within one hour of
presentation .
Contraindications:
As for emesis but can be used for hysterical ,
comatosed ,or any uncooperative patient
Precautions :
1- In case of C.N.S depression or pulmonary irritant
ingestion insert cuffed endotracheal tube before lavaging
2-It can be performed under general anesthesia in patient
with convulsions
Procedure :
Tube:150 cm long ,1.25 cm in diameter Having multiple
openings on sides &At tips.
Contraindications
d) Cathartics:
two groups are present :
1) saline cathartics :e.g. sodium sulphate ,magnesium
sulphate
2) Saccharides :e.g.e.g. sorbitol (is the cathartic of
choice )
Contraindication:
Ingestion of corrosive, sever diarrhea,ileus ,serious
electrolyte imbalance &bowel injury
e)Whole bowel irrigation
It is a useful safe &rapid method to empty the gut in 4-6
hours .It produces a through cleansing of the entire
intestinal tract
Method :
By use of High molecular weight polyethelene glycol (PEG)
and isosomlar electrolyte solution (sodium sulphate) are
used as isotonic solutions for WBI and available as
Golytely & Colyte
Indications:
• Ingestion of massive amounts of highly toxic drugs .
• Ingestion of large amounts of drugs in patients
presenting late(more than 4 hours)
• Ingestion of drug packets by body packers (cocaine
filled packets ) ()تجار المخدرات
• Ingestion of substances not adsorbed by activated
charcoal
Contraindications:
- G.I.T Haemorrhage ,perforation ,ileus
&obstruction
- Inadequate air way protection .
f) Surgical decontamination:
Indications :
Concretion of sustained-release tablets .
Drug packets by body packers or body stuffers
Patients with bowel obstruction
When there is a contraindication to gut
decontamination.
g) Local antidotes:
1- Adsorbents : Activated charcoal
2-Dilution&Neutralization:
dilution with fluids (water or milk)
But note that :
If Alkali (any strength ) or weak acid caustic ,the oral
dilution with cold fluids immediately after exposure may
reduce oropharyngeal & gastric mucosal damage as it
reduce the contact time with tissues .
If strong acid :It is contraindicated due to production of
heat &gases which lead to more destruction of tissues
3-precipitation مهم
e.g. tannic acid for= alkaloids e.g opium
Albumin water =mercury
Magnesium sulphate=Carbolic acid
Calcium hydroxide =oxalic acid
4-oxidation
potassium permanganate solution =oxidize most
alkaloids e.g.Atropin
cupper sulphate =phosphorus
5- Reduction
e.g. sodium formaldhyde sulphoxylate = reduce mercuric
chloride to metallic mercury which is less soluble &thus
non absorbable.
INDICATIONS
In toxicity with drug that are:
(1) Weak acid or weak base
(2) Low protein binding
(3) Have limited metabolism
(4) Have high renal clearance
(5) Have small volume of distribution
COMPLICATIONS
(1) Fluid overload
(2) Pulmonary oedema
(3) Cerebral oedema
(4) Acid base disturbance
(5) Electrolyte imbalance
INVESTIGATION
(1)Plasma drug concentration
(2)Fluid balance
(3)Central venous pressure
(4)Electrolytes , Serum sodium, Potassium. calcium and
magnesium
ACID DIURESIS
INDICATIONS
Amphetamine .strechnine. Quinidine and
phencyclidine
METHOD
500ML dextrose 5%+
500ml saline 0.9%+
75ml ammonium chloride 2% give over 6 hours
ALKALINE DIURESIS
INDICATIONS
Salicylates phenobarbital and phenoxyacetate herbicide
METHOD
500ml dextrose 5%+
500ml saline 0.9% +
500ml Na bicarbonate 1.26% over 3_4 hours
HEMODIALYSIS
Only eliminate drugs or toxins which can pass easily
across the dialysis membrane
i.e characterized by
A) low molecular weight
B) high water solubility
C) small volume of distribution
(high plasma concentration)
INDICATIONS
1)Several clinical intoxications with vital signs
abnormalities such as apnea, hypotension that do not
respond to supportive care.
2)Impaired normal excretion routes e.g renal failure
3)progressive clinical deterioration and presence of
complications such as aspiration pneumonia
4)prolonged coma with complications
5)presence of underlying diseases .
6)ingestion of alethal dose of poison .
7)ingestion of large dose of toxin that is metabolized to
more toxic metabolites such as methanol and ethylene
glycol .
8)drug produce delayed toxicity e.g paraquat.
CONTRAINDICATIONS
1) Presence of antidotes
2)Coagulopathy
3)Cardiogenic shock
4) Non dialyzable toxins
COMPLICATIONS
1) Hypotension
2) Electrolyte and Osmolar imbalance
3) Hypoxemia
4) Vascular access Complications
5) Spontaneous Bleeding
6) Infections
7) mechanical Complications
8)sever anaphylactic
9)sudden death fromMachine malfunction,
Electrocution& Coagulopathy
3-HemoPerfusion
Blood is pumped through a cartridge of absorbent material
(activated charcoal or resins)
Indications:-
The same as in hem dialysis, but hemoperfusion is not
limited by the high molecular weight, protein binding or
poor water solubility of the toxin because charcoal or resin
can adsorb these toxins
Contraindication:-
Similar to those for hem dialysis
Complications:-
Similar to those for hem dialysis + thrombocytopenia,
leucopenia and hypocalcaemia
4- Peritoneal dialysis :-
Peritoneal dialysis operates on principles similar to those
of hem dialysis diffusions of toxins from mesenteric
capillaries across the peritoneal ( membrane into dial sate
dwelling in the peritoneal cavity
Indications:-
1- Patients with acute renal failure
2- Patients with bleeding disorders
3- Patients with venous access problems
4- Hem dialysis is not available
5- Patients for whom hem dialysis and
hemoperfusion are contraindicated
Method:-
Through a catheter inserted intraperitoneally , adialysate
fluid is instilled and 1-2 liters is exchanged each hours
Complications:-
1- Pain
2- Hemorrhage
3- Leakage
4- Inadequate drainage
5- Perforation of viscera
6- Bacterial peritonitis
7- Arrhythmias
8- Volume depletion or overload
9- Hyperglycemia and electrolyte disorders
10- Pneumonic and pleural effusion
5- Gut dialysis :-
Complications :-
7- Exchange Transfusion:-
1-B.A.L.
B.A.L=British anti-lewisite (lewisite is the gas of war)
Mechanism of Action:
It acts by fixing the metal ions which have high affinity for
SH group forming a relatively harmless &poorly dissociable
ring compounds ‘chelates ‘ that prevent the poison from
inactivating the SH containing respiratory enzymes .
Uses:
It is the physiological antidote of poisoning with
heavy metals e.g. Arsenic, Mercury, Antimony,
Antimony, and Gold &Bismuth.
It is of little value in ttt of lead poisoning because it
only chelate lead ions present in the blood while the
ions in the bones &tissues are too firmly bound to be
mobilized by it
BAL is not used in iron poisoning because BAL – iron
complex is even more toxic than the unchelated iron.
Dose:
Deep I.M. injection of 10% BAL in peanut oil is given in a
dose of 2.5 mg/kg body weight every 4-6 hours for 2 days
then every 12 hours for 7-10 days.
Why deep? To avoid abscess formation
EDETA
EDETA&EDETA salts :[ Na2 EDETA &Ca Na2 EDETA ]
Ca salts are used because rapid I.V. administration of
Na2 EDETA result in hypocalcemic tetany .This is the
reflection of high affinity of EDTA for calcium.
CaNa2EdETA can chelate any metal that has a
greater affinity for EDETA than has calcium & can
thus replace calcium from the complex
Lead has high affinity for EDETA than calcium &can
replace calcium in the complex forming a poorly
dissociable chelate which is harmless &excreted in
urine.
Mercury poisoning responds poorly to ttt with Ca Na 2
EDETA in vitro because it doesn’t pass into areas of
mercury
Dose:
CaNa2 edetate injection 20%solution 1g. (5ml)in 250-
500 ml of 5% glucose in water or saline solution
slowly by IV drip over a 1 hour period ,twice daily for
3-5 days
The drug is then withheld for 2 days to allow
redistribution of the lead, thus increasing the amount
of metal available for chelation.
Dicobalt Edetate (Kelocyanor)
It is a cobalt salt that forms a relatively nontoxic
stable ion complex with cyanide.
Dose :
300mg I.V Followed immediately by 50 ml of 50% glucose
I.v this may be repeated after 5 minutes if there is no
response .
Side effects :Vomiting ,urticaria ,facial &neck edema
,hypotension ,chest pain &anaphylactic shock .
Penicillamine :
It posses one SH group
It is prepared by hydrolic degradation of penicillin .
It is an effective chelator of Copper ,Mercury, zinc
&lead that promotes their excretion in urine
It is well absorbed from G.I.T so it can be given orally
.
Dose :
Penicillamine capsules :250 mg/capsules the usual
dose is 1-2 capsules (250-500mg) every 6 hours on
empty stomach to avoid interference by dietary
metals .
Deferoxamine ( Desferal )
It is the chemically modified metal free ligand from
streptomyces pilosus .
It has high affinity for ferric ions ,& very low affinity
for calcium
It readily competes for the iron of ferritin
&hemosiderin ,but
the iron of transferring is very minimally affected
Dose:
Deferroxamine mesylate 500mg ampules .
1g is given I.M ,followed by 500 mg every 4hours for
two doses .
The dose can be repeated at 4 or 12 hours intervals
,depending on clinical response ,but a total of 6g/24
hours shouldn't be exceeded
In case of acute iron toxicity ,8g has to be given by
nasogastric tube to be followed by IM injection
described above
DMSA (Succimer)
DMSA is relatively selective orally active water
soluble chelating agent
It can be used in ttt of lead , arsenic ,organic
&inorganic mercury poisoning .
It is more effective than I.V. CaNa2-EDTA in lowering
blood lead level , restoring red cell gamma
aminolevulinic acid dehydratase (ALA-D)activity ,and
increasing urinary lead excretion .
Dose
10 mg /kg/8hrs orally for 5 days followed by
10mg/kg/12 hr for 14 days to delay the eventual
rebound in blood lead concentration.
Advantages of DMSA
1- It is less toxic
2- Orally active&highly effective .
3- Relatively specific i.e. doesn't significantly chelate ca
,Mg,Fe, Cu, &Zn.
4- Given safely to patient with G6Pd deficiency while
BAL can cause hemolysis
5- Iron supplementation can be given concomitantly
with DMSA without any adverse effects ,while BAL –
Iron complex is a potent emetic
تطبيق
عايزين نطبق اللي خدناه
كويس
7-Supportive Therapy.
تطبيق تاني
CO poisoning
الخطوات بتاعتنا ايه؟
1-
2-
3-
4-
5-
6-
7-
ماشي
طب افرض مثل أن التعرض كان بكمية بسيطة والشخص جالك وقالك أنا
ي خلص طالما فايق أحطه تحت الملحظة
أغمى عل ّ
7- Supportive Therapy.
ممكن ايه
Warm patient with blankets
Blood transfusion
Part 2
Corrosives
General characters:
– هنجيب العراض من فوق لتحت من أول الفم وبعدين الحنجرة والبلعوم
أمعاء- مرئ –معدة
8-ttt
Cause of death
A-Early ''Immediate ''
*Shock ,collapse :due destructive action on mucosa
(Neurogenic due to sever pain
Hypovolemic due to vomiting & diarrhea )
**Asphyxia :due to choking from acute oedema of
glottis caused by irritating fumes e.g. Ammonia ,nitric
,acetic acid
B-Late
*Gastric perforation ,Peritonitis : in case of deep
ulceration reaching muscle layer
**Cashexia ,Emaciation :from chronic starvation
resulting from cicatricial contraction of oesophagus
,stomach ,pylorus or impaired gastric function
هنبدأ بالحماض
وأدي أول جدول
بس حضرتك اللي هتكتبه لن المنتدى ل يقبل الجداول
خانات4 هنعمل جدول
هنقارن بين الحماض الغير عضوية الكبريتيك والهيدروكلوريك والنيتريك
و خانة وجه المقارنة
#3C
Constipation (Because Acid)
Collapse
Cold Clammy skin
وهنزود في النيتريك
More volatile Irritate airway passage, Edema of glottis
Coughing, Dyspnea
Pulmonary complications as bronchitis ,bronchopneumonia
Treatment
هنقول نفس الكلم فوق
بس هنزود
• Egg white or olive oil can be used as demulcent
• Morphine 5-15 mg IV for sever pain ,shock
• I.V. fluids for dehydration ,correction of electrolyte
imbalance
• Nutrient enemata can be used Surgical ttt graft
operation in oesophageal stricture
Post mortem
نفس الكلم ف الثلثة
• Necrosis of mm
• Lesions in larynx ,esophagus, stomach may show
haemorrhage with altered blood
• Antemortem or postmortem perforation in stomach
may occur
• With HCL +dirty white to ashy grey nccrosis of
mucosa .
الجدول التاني
الله المستعان
هنقارن بين
Carbolic &oxalic
الول كلمتين ع الفنيك قبل ما نقول الجدول
أهم حاجة واحنا بنذاكر ال
Toxicology
هي أنك تعرف
الtarget organ
وتعرف ال
Mechanism of action
وأنت هتقول الباقي لوحدك
Carbolic
من اسمه هنطلع بيؤثر على ايه
حرفcCNS
حرفr renal
حرفcCVS
علىCNS
Stimulation followed by depression
وعلشان نتفق بعد كده أي حاجة هتلقي فيها
Stimulation on CNS
هنقول
Irritability, Restlessness, Anxiety
Agitation, Hallucinations, Convulsions
لنها هتتكرر بعد كده كتير فمش كل شوية هنقعد نقول كلم مش شكل
)بعضه)زي ما بقول لك كده هنحط الكلمتين دول وهيطلعو صح
علىRenal
Direct toxic nephritis (Acute Glom.Nephritis)
Renal failure with oliguria or even anuria
Urine contain Blood &albumin cast, Turns Green on
Exposure to air due to formation of Hydroquinone
(oxidative product of phenol)
علىCVS
Myocardial depression
Ventricular arrhythmias, Rapid, weak, irregular pulse
Marked hypotension, Subnormal temperature
Carbolic
SourcePhenol is used as disinfectant ,insecticide &in
Some outpatient Pediatric surgery .
Phenique contains 2-5%phenol
It is also present in Cresol
NB It can be absorbed from intact skin
Oxalic
Sourcein Bleaches &metal cleaners &many plants
especially citrus fruit &rhubarb leaves
CarbolicFatal dose3-6 gm
OxalicFatal dose15-30gm
Oxalic
Local action
1- Local corrosive action on alimentary tract
2- With production of gastroenteritis
Remote action
أول ما تسمع أوكزاليك على طول يجي علي بالك الكالسيوم
Oxalic acid chelates ionisable calcium from the blood
symptoms Related to hypocalcaemia
When large fatal dose is taken it produce fatal
decalcification of blood
Also calcium Oxalate crystals Plug Renal Tubules
Renal Failure within 10 days Death occurs
Clinical picture
Carbolic
• Burning sensation in mouth,oesophagus ,stomach
followed by Tingling due to local anesthetic action
• No or scanty vomiting due to local anesthetic
action
• Ishures colour
Around mouth Brownish
At mouth & oesophagus Whitish
With characteristic aromatic odour
• من الحاجات اللي بيؤثر عليها عندنا ايه
CNS at first anxiety then followed by coma with
cyanosis
الكلم اللي قولناه فوق
CVS
Pulse
Bl.Pressure
Temperature
Respir.
*Pupils constricted reactive
(N.B. in Morphine Poisoning pinpoint pupil Irreactive )
Arrhythmia
Large dose coma with unrecordable blood pressure
,Resp. arrest ,death
Delayed death from acute Renal failure
Oxalic
حاجات3 هنتكلم على
الولى
• It has local corrosive effect Sever pain in mouth
,esophagus ,stomach +sever vomiting
&haematemsis+oxalate crystals in vomitus
+Diarrhea (dehydration ,collapse )
خللي بالك أن ده حمض وعمل
Diarrhea
على العكس من باقي الحماض
التانية
• Large fatal dose Death in few minutes due to
fatal decalcification as Ca is necessary for muscle
contraction &nerve coduction So cause of death is
CNS depression & Myocardial depression
التالتة
• Sublethal dose
Symptoms &signs are of hypocalcemia as
#Muscle twitches ,Ms cramps, tetany
#Cardiac arrhythemia, convulsions
#Shock, stupor, coma
Ca oxalate crystals are deposited in Bl.vessels
,Kidney ,liver heart ,lungs
Renal tubules Oliguria or even anuria Death from
Uremia
Urine contain Ca oxalate crystals +blood +albumin
Treatment
Carbolic
1-Prevent further exposure .
2-Emergency stabilization of the patient.
3-Proper clinical evaluation .
4- Prevent further absorption .
Skin decontamination with extensive irrigation using H2O
then Olive Oil
Gastric Decontamination
Emesis: Not contraindicated Because we said scanty
vomiting or no vomiting at all
Stomach wash: Is allowed No fear of perforation due to
coagulative necrosis wall is thick
Stomach wash is done using water then olive oil as it
dissolves phenol &prevent its absorption
After lavaging you can leave olive oil in the stomach as
local antidate that retard absorption of any remaining
phenol Also we can leave Mg sulphate to ppt poison as Mg
sulpho carbolate
5- Eliminate absorbed poison .
Dialysis isn't beneficial here so ttt is mainly supportive
6- Antidotal therapy if available.
7- Supportive Therapy.
Supportive in coma
المقصود هنا مش الكوما كوكتيل اللي قولنا عليه
المقصود أن لو العيان ده فضل عندي في المستشفي مغمى عليه
Prolonged Coma
فيهMeasures تانية
1- Maintenance of body temp. by blankets
2- Frequent change in patient's position with rubbing
skin with alcohol to avoid bedsores
3- Prophylactic antibiotic safe guard against
bronchopneumonia
4- Regular catheterization for liability of retention of
urine
5- Maintenencce of Fluid &electrolyte balance especially
Potassium
#Safeguard against resp.
#ttt of shock
#symptomatic ttt
# Follow up this patient For fear of oesophageal stricture
Oxalic
1-Prevent further exposure .
2-Emergency stabilization of the patient.
Here it is life saving to give this patient Calcium
gluconate I.V.to prevent hypocalcemia
Also rapidly make patient orally drink calcium
lactate water and /or milk to supply large amount
of calcium to inactivate Oxalate by forming an
insoluble calcium oxalate in the stomach . lime