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By: Charlene N. Rivera Bonet RISE Program Summer 2012

By: Charlene N. Rivera Bonet RISE Program Summer 2012

Objectives

  • Analyze if there is a hormone-dopamine

relation. (Specially testosterone)

  • Help to find new ways to treat Tourette ’s syndrome.

Intoduction

What is Tourette’s Syndrome?

  • Involuntary, unusual movements or

sounds, “tics.”

  • Theory of excessive amount of dopamine produced.

Introduction

Statistics

  • More common in men than in women.

  • Twice as common among teenagers as among children.

Introduction

Comparison

  • Parkinson

    • - Trembling

    • - Is more common in men than in women.

    • - Men 50 or more.

    • - Neurons that make dopamine die or do not work properly.

What is dopamine?

  • Neurotransmissor produced in the basal

ganglia.

What is dopamine?  Neurotransmissor produced in the basal ganglia. <a href=http://imueos.wordpress.com/page/7/ " id="pdf-obj-5-9" src="pdf-obj-5-9.jpg">

What is dopamine?

  • Regulates:

-movement

-emotion (also affected by hormones)

-motivation

-pleasure

Hypothesis

  • Hormone levels can interfere with

dopamine production.

Why?

  • One of the most remarkable differences between men and women are hormones.

  • Tourette’s syndrome is diagnosed in

teenagers in a higher rate. Stage in

which hormones are raging.

Methodology

  • Experimental Group

-16 men with Tourette’s Syndrome

  • 4 children (6-11)

  • 8 teenagers (12-17)

  • 4 adults (18 & up)

-16 women with Tourette’s Syndrome

  • 4 children

  • 8 teenagers

  • 4 adults

Methodology

  • Control Group

-16 men without Tourette’s Syndrome

  • 4 children

  • 8 teenagers

  • 4 adults -16 women without Tourette’s Syndrome

  • 4 children

  • 8 teenagers

  • 4 adults

Methodology

  • Similar life styles.

  • Measure levels of bio-available

testosterone and estrogen.

  • Measure dopamine production through DaT Scan.

  • Institutional Review Board (IRB) consent and assent pages will be needed.

Expected Results

  • Men with higher levels of testosterone

will have a greater dopamine production,

men with low levels of testosterone will have less dopamine production.

  • Tourette’s Syndrome patients will have above normal testosterone levels, consequently a higher rate of dopamine

production.

References

  • Feldman R., Meyer J., Quenzer L. 1997. Principles of Neuropsychopharmacology. Sinaucer Associates, Inc. p 288-

301

Thank You for your Attention!