A CROSS SECTIONAL STUDY TO KNOW THE RELATIONSHIP BETWEEN SEVERITY OF THROMBOCYTOPENIA AND SEVERITY OF DENGUE IN PEDIATRIC WARD OF GGH,

KURNOOL

By:

K. Jagannath Singh. Teacher Indus High School Kurnool

INTRODUCTION

Dengue fever is a major public health problem in tropical and subtropical countries The reasons for the emergence of this disease are complex Effective mosquito control is virtually nonexistent in most dengue-endemic countries Major global demographic changes have occurred Uncontrolled urbanization Concurrent population growth Substandard housing, inadequate water, sewer, and waste management systems

AIMS & OBJECTIVES

To reveal the prevalence of Dengue among suspected case of dengue(VHF) Understand the relationship between severity of thrombocytopenia versus severity of Dengue To study whether the platelet count bears any relation with new WHO classification of Dengue(2009)

GEOGRAPHIC DISTRIBUTION OF DENGUE

CAUSATIVE AGENT OF DENGUE

Dengue is cause by a RNA virus This virus is a member of the viral family Flaviviridae.

Dengue virus

VECTORS
Aedes aegypti
Aedes albopictus

AEDES AEGYPTI LIFE CYCLE

2-7 days >4 days 2days

VECTOR BREEDING SPOTS

Dengue is one disease entity with different clinical presentations and often with unpredictable clinical evolution and outcome

CASE DEFINITION

RASH & CONJUNCTIVAL HEMORRHAGE

MATERIAL & METHODS

Study settings:

/GGH Kurnool Study design :Cross-sectional study Study subjects:70 Sampling method: All suspected cases of Dengue admitted in pediatric ward Study period: Schedule 1.06.2011 to19.09.2011 Data collected was analyzed in MS excel

Pediatric ward of KMC

OBSERVATIONS
Mean age: 4 years Mode for age:3 Median for age:7 years Range:7 months to 14 years

Mean platelet count:33,214 Mode:40,000 Median:47,000 Range:2000 to 1,00,000

DISTRIBUTION OF DENGUE

DISTRIBUTION OF PLATELET COUNTS

CALCULATION
Total Platelets Severe Dengue (+ve) Severe Dengue (-ve)

20,000

10

16 54 70

> 20,000
Total

14
24

40
46

Chi square value > 7.29 P value < 0.01 (highly significant) df=1

DISCUSSION
In my study 43 were +Ve for dengue among them 24 were diagnosed as sever Dengue out of 70 cases of Dengue In K. Oishi and all in,Nagasaki university,Japan. 38 were +Ve for sever dengue among 78 cases of secondary dengue

CONCLUSIONS

The prevalence rate of Dengue is (43/70 100) Age wise distribution of Dengue cases Gender distribution of dengue Distribution of cases according to WHO classification of Dengue Relation among platelet counts and different forms of Dengue Case fatality rate (3/70 100) The strength of association between severity of Dengue and severity of thrombocytopenia was found to be statistically significant with a P value <0.01.(Chi square value of 7.29 with 1 df)

ACKNOWLEDGEMENTS
Special thanks to my beloved Professors: Dr. P.Sudhakar Rao MD Gen Med Dr. A.Sreedevi Prof & HOD of SPM Assistant professor: Dr.S.Cynthia Subhaprada My colleagues: Bala Kumar.D Divya.B Bhupathi Naidu.K

REFERENCES

WHO Library Cataloguing-in-Publication Data Dengue: guidelines for diagnosis, treatment, prevention and control -- New edition. 1.Dengue - diagnosis. 2.Dengue - therapy. 3.Dengue - prevention and control. 4.Endemic Diseases prevention and control. 5.Fluid therapy. 6.Diagnosis, differential. 7.Disease outbreaks - prevention and control. 8.Mosquito control. 9.Guidelines. I.World Health Organization. ISBN 978 92 4 1
Mayo clinic, (2010). Dengue fever symptoms. Retrieved April 19, 2010 from http://www.mayoclinic.com/health/dengue_fever/DS01028/DSECTION=symptoms

54787 1 (NLM classification: WC 528) World Health Organization, (2009). Dengue and Dengue haemorrhagic fever. Retrieved April 19, 2010 from http://www.who.int/mediacentre/factsheets/fs117/en

LIST OF RECOMMENDED SOURCES:

Dengue Fever , disease information: http://www.cdc.gov/ncidod/Diseases/submen us/sub_dengue.htm CDC-Dengue: http://www.cdc.gov/ncidod/dvbid/dengue/ WHO/Dengue/dengue haemorrhagic fever: http://www.who.int/csr/disease/dengue/en/

Thank you