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Antioxidants
Vitamins A, C, E
Beta-carotene
Lutein
Selenium
Zinc
Lycopene
CoQ10
Archie:
The data should concern any oncologist that the data are
meaningless.
D’Andrea should be careful not to inappropriately bias the
readership of CA: A Cancer Journal for Clinicians against
supplements which may actually be helpful and not
harmful.
Vitamin C and
Radiation
Blocks COX-2
High dose of CoQ10 associated with
fewer deaths in women with metastatic
breast cancer
Lockwood, Biochem Biophys Res Commun 1995 July 6;212(1):172
CoQ10 and Tamoxifen
Doxorubicin (Adriamycin)
Increased risk for congestive heart
failure
CoQ10 protects against this risk
without interfering with the cytotoxic
effect of the drug
Konklin. J Nutr. 134(11) 3201S.
CoQ10 and
Radiation
Pancreatic Cancer
Vitamin A palmitate 50,000 iu orally twice
per day plus b-interferon and combined
chemotherapy (epirubicin, mitomycin C, and
5-fluorouracil)
Prolonged symptom palliation in 35%pts
Fairly toxic combination, however only toxic
effect attributed to Vit A was hepatic
Also helpful in non-lymphocytic leukemia
Vitamin A and
Radiation
Platinum-containing (cisplatin)
Melatonin and
Chemotherapy
100 people with metastatic Non-small cell
Lung cancer randomized to chemo alone vs.
chemo plus melatonin 20mg/day
5-year survival higher in melatonin group
(6% vs. 0%)
Chemotherapy better tolerated in melatonin group.
Similar effects seen in RCTs of colorectal
cancer and effective vs cancer-related
thrombocytopenia
Lissoni. J Pineal Res 2003;35:12
Cerea et al. Anticancer Res.2003;23:1951
Lissoni et al. J Pineal Res 2001;30:123
Melatonin and
Radiation
RCT Glioblastoma
Radiation +/- melatonin 20mg
Increased 1 year survival in melatonin
group
6/14 vs 1/14 still alive
Fewer side effects in melatonin group
Lissoni. Onc. 1996;53:43
N-acetylcysteine
NCI website:
“Side effects of cancer and cancer treatments make it
difficult to eat well…Malnutrition can result, causing the
patient to be weak, tired, and unable to resist infections or
withstand cancer therapies.”
Yale University
“In addition to weight lost prior to the diagnosis of head
and neck cancer, the patient may lose an additional 10% of
pre-therapy body weight during radiotherapy or combined-
modality treatment.”
effects of chemotherapy
Chinese Medicine
and Radiation
Angiostatic
resveratrol, EGCG, silymarin,
grapeseed extract, quercetin,
green tea, gingko, curcmin, resveratrol, soy
Therapy
ginger isoflavones,
squalamine, Vit D scutellaria,
artemsia curcumin, EPA
silymarin, glycine, cartilege,
mistletoe
silymarin, Cu antagonists
curcumin
green tea
scutellaria
Silymarin,
Glycine, Ginger