Académique Documents
Professionnel Documents
Culture Documents
Neonatal Jaundice
Learning Objectives: Define hyperbilirubinemia. Differentiate between physiological and pathological jaundice. State causes of hyperbilirubinemia. Discuss the pathophysiology of hyperbilirubinemia. Describe the most dangerous complication of hyperbilirubinemia. List the three elements of therapeutic management. Design plan of care for baby has NJ - 2 hyperbilirubinemia.
NJ - 4
Neonatal Jaundice
Visible form of bilirubinemia
NJ - 5
Bilirubin
Ligandin (Y - acceptor)
Bilirubin glucuronidase
Intestine
Bil glucuronide
Bil glucuronide
glucuronidase bacteria
Bilirubin
Stercobilin
Bilirubin metabolism
NJ - 6
NJ - 7
Physiological jaundice
Characteristics Appears after 24 hours Maximum intensity by 4th-5th day in term & 7th day in preterm Serum level less than 15 mg / dl Clinically not detectable after 14 days Disappears without any treatment
Note: Baby should, however, be watched for worsening jaundice.
NJ - 9
Preterm 11 12 13
Age in Days
NJ - 11
Pathological jaundice
Appears within 24 hours of age Increase of bilirubin > 5 mg / dl / day Serum bilirubin > 15 mg / dl Jaundice persisting after 14 days Stool clay / white colored and urine staining clothes yellow Direct bilirubin> 2 mg / dl
NJ - 12
Causes of jaundice
Appearing within 24 hours of age Hemolytic disease of NB : Rh, ABO Infections: TORCH, malaria, bacterial G6PD deficiency
NJ - 13
Causes of jaundice
Appearing between 24-72 hours of life Physiological Sepsis Polycythemia Intraventricular hemorrhage Increased entero-hepatic circulation
NJ - 14
Causes of jaundice
After 72 hours of age Sepsis Cephalhaematoma Neonatal hepatitis Extra-hepatic biliary atresia Breast milk jaundice Metabolic disorders (G6PD).
NJ - 15
Diagnostic evaluation:
Normal values of unconjugated B. are 0.2 to 1.4 mg/dL. Investigate the cause of jaundice.
NJ - 17
Therapeutic Management
Purposes: reduce level of serum bilirubin and prevent bilirubin toxicity Prevention of hyperbilirubinemia: early feeds, adequate hydration Reduction of bilirubin levels: phototherapy, exchange transfusion, Drugs Use of Phenobarbital promote liver enzymes and protein synthesis.
NJ - 18
Prognosis
Early recognition and treatment of hyperbilirubinemia prevents severe brain damage.
NJ - 21
jaundice at regular intervals. Jaundice is common in the first week of life and may be missed in dark skinned babies
Nursing diagnosis
See the high risk infant plan of care. Plus: Body T., risk for imbalanced T. related to use of phototherapy. Fluid volume, risk for deficient related to phototherapy. Interrupted family process related to situational crisis, re hospitalization for the therapy.
NJ - 24
QUESTIONS?
NJ - 26