MEL GIBSON

NICHOLAS
CAGE
P2RY5 IS
CAUSE OF

DR AZLINA AHMAD ANNUAR

MTEB 3303 CURRENT TOPICS IN BIOMEDICAL SCIENCE
THE NEWSPAPER
ARTICLES
•News Straits Times
•03 March 2008

•RESEARCHERS have
found the genetic
basis of two distinct
forms of inherited
hair loss, opening a
broad path to
treatments for
thinning locks,
according to a
recent pair of
Human hair
• Hair structures
– Follicle in the skin
Several layer
– Shaft
keratin
Three layer
o Medulla
o Cortex
o Cuticle
 Hair
loss
• Normal ?
cycle hair
growth lasts for 2 to 6
years
• Approximately 1 cm per
month
• Causes hair loss:
– Major surgery
– After 3 months delivery
– Medicines
– Hormonal problems
Thyroid gland
Androgen & Estrogen
 What is the
• Symbol to:P2RY5 ?
– Purinergic receptor P2Y, G-protein coupled,
5
• Gene type:
– Protein coding
• Summary:
– The protein encoded by this gene belongs
to the family of G-protein coupled
receptors, that are preferentially activated
by adenosine and uridine nucleotides
– This gene aligns with an internal intron of
the retinoblastoma susceptibility gene in
the reverse orientation.
Research on P2RY5
Methodology
 Study findings
• The P2RY5 is the first receptor in human
– Roles in hair growth
• Study shown it was cause from:
– Rare inherited form called
hypotrichosis simplex
• Hypotrichosis simplex
– An autosomal dominant form of
isolated alopecia
– Complete loss of scalp hair
 Study findings
• The disease affects both men
and women
– Begin to bald
during childhood
• Genetic defect
– Prevent certain
receptor on the surface of hair
follicle cells
 Study
findings
• The P2RY5 plays a
specific role in hair
growth
• For hair follicle function
normal
– Messenger bind to
these receptor
– Triggering a chain
reaction in the cell
interior
• This study revealed the
related substances to
Others
StudyAngela
Christiano
( Columbia
University)

STUDY
RESULT
- On P2RY5
- Woolly hair
- Among families in
Pakistan - Sparse
- Mutation on inner root - Dry
sheath of hair follicles
 Comments
• Bias on the
subject matter
–Arabians
–Pakistans
• Recommended
–Broader
subject
(worldwide)
Bold is beautiful ?
 References
• Ahmad, W. et al. Alopecia universalis associated with a mutation in the human
hairless gene. Science 279, 720–724 (1998).

• Al Aboud, D., Al Aboud, K., Al Hawsawi, K. & Al Aboud, A. Hereditary

hypotrichosis simplex of the scalp: a report of 2 additional families. Sudan J.
Dermatol. 3, 128–131(2005).

• Al Aboud, K., Al Hawsawi, K., Al Aboud, D. & Al Githami, A. Hereditary

hypotrichosis simplex: report of a family. Clin. Exp. Dermatol. 27, 654–656
(2002).

• Herzog, H., Darby, K., Hort, Y.J. & Shine, J. Intron 17 of the human retinoblastoma
susceptibility gene encodes an actively transcribed G protein-coupled receptor gene.
Genome Res. 6, 858–861 (1996).

• Sandra M Pasternack, Ivar von Ku¨gelgen, Khalid Al Aboud, Young-Ae Lee, Franz
Ru¨schendorf,Katrin Voss, Axel M Hillmer, Gerhard J Molderings, Thomas Franz,
Alfredo Ramirez,Peter Nu¨rnberg, Markus M No¨then & Regina C Betz. G
THANK