Académique Documents
Professionnel Documents
Culture Documents
Ivica Rubelj
Skeptici 2013
to je starenje?
Starenje je proces sveobuhvatnog, ireverzibilnog i progresivnog tjelesnog propadanja koje se dogaa tijekom vremena.
Genes, Aging, and Immortality. Charlotte A. Spencer
Starenje
Stanino starenje
L. Hayflick
HL
In vitro
mladi fibroblasti
stari fibroblasti
In vivo
35 god.
75 god.
TELOMERE ?
Telomere
Teorija marginotomije
mlade
stare
Telomeraza
Telomeraza
C. Greider
J. Shay HL
W. Wright
HL
Mice overexpressing telomerase (TERT) age more slowly than normal mice. (Blasco laboratory)
Maria A. Blasco
Tert delays ageing. Survival curves and % mice living for more than three years. Neuromuscular coordination as % of mice passing the tightrope test.
Tomas-Loba et al. Cell 135, 609622, November 14, 2008
Or Not.
TWO MICE INVOLVED IN AN EXPERIMENT ON AGE-RELATED DEGENERATION. MICE WHOSE TELOMERASE GENE WAS ACTIVATED SHOWED NOTABLE IMPROVEMENTS
Adapted from: Tsuji, A., A. Ishiko, et al. (2002). "Estimating age of humans based on telomere shortening." Forensic Sci Int 126(3): 197-9.
Predikcija dugovjenosti?
Association of telomere length in blood DNA after age 60 with subsequent survival. Data are plotted as fitted and smoothed survival curves, according to the group prognosis method. Longer identifies individuals from the top half of the telomere length distribution and shorter those from the bottom half of the distribution. Years since draw means the interval ending with that year (eg, 71 people at risk at end of year 1 for longer group, both sexes).
The relationship between telomere length and survival in humans (after Bakaysa et al. 2007). Those with the longest telomere lengths have the highest survival prospects.
Telomere length (adjusted for age, gender, and group) according to the absence (gray bars) or presence (white bars) of various age-related diseases in the study subjects. Number of individuals analyzed in each group: hypertension (n = 125), without hypertension (n = 142), with the metabolic syndrome (n = 59), without the metabolic syndrome (n = 286), diabetes (n = 34), without diabetes (n = 276). The MMSE (Mini-Mental State Examination) was performed in centenarians only: MMSE score 25 (gray bars, n = 46) or >25 (white bars, n = 32). *P < 0.05.
STRES
!
Telomere length and telomerase activity levels in extreme high- and low-stress groups. (A) Average telomere length and SE are shown. The highstress group had shorter telomeres even after controlling for age. (B) Average telomerase activity and SE are shown. The high-stress group had lower telomerase activity even after controlling for age.
Longer lives: In tests, the anti-ageing pill increased the life expectancy of animals by 38 per cent
Starenje i prehrana
Resveratrol
ANALITIKA TELOMERA
Laboratorij za molekularnu i staninu biologiju, IRB
Elizabeth Blackburn
Anti-aging food
ZAHVALJUJEM NA POZORNOSTI