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Budiana Tanurahardja/ Rahmiati/Lisnawati DEPARTMENT of ANATOMIC PATHOLOGY FACULTY OF MEDICINE UNIVERSITY of INDONESIA 2013
Vascular Pathology
Normal blood vessels. Aneurysms. Hypertension. Vasculitis. Varices. Neoplasms.
Capillaries: 7 - 8 u.
Postcapillary venules. Collecting venule.
Endothel :
Weibel- Palade bodies 0,1x0,3u storage organelle for vWF.
Aneurysm
Aneurysm
Aneurysm is localized abnormal dilatation of blood vessel. True and false Saccular and fusiform. Etiology: atherosclerosis, cystic medial degeneration, congenital, infection (mycotic aneurysm), syphilis, trauma,systemic disease, immunologic. Dissecting aneurysm: blood enters the wall of the artery, dissecting the layers.
Berry aneurysm
Occurrence among patient with
Berry aneurysm
heritable systemic disorders ( autosomal dominant polycystic kidney, Ehlers-Danlos syndrome type IV,neurofibromatosis type I, Marfan syndrome) fibromuscular dysplasia of arteries coarctation of aorta
Berry aneurysm
Saccular aneurysm.
Berry aneurysm
The 4th most common CVA after : atherosclerotic thrombosis, embolism and hypertensive haemorrhage.
2 % in autopsy.
Pathogenesis: unknown.
Genetic factor may be important.
Berry aneurysm
Berry aneurysm
Berry aneurysm
Berry aneurysm
Aneurysm
Aneurysm
Dissecting aneurysm
Dissecting Aneurysm
systolic
< 130 130-139 140-159 160-179 180-209 > 210
diastolic
< 85 85-89 90-99 100-109 110-119 > 120
Morphology
Hyaline arteriolosclerosis:
in elderly patients normotensive or hypertensive, but more generalized and severe in hypertensive.
Arteriolosclerosis
Elderly patient: normal/hypertensive.
Diabetes.
Leakage plasma component ,matrix production by smooth muscle cells hyaline deposition. benign nephrosclerosis.
Arteriolosclerosis
Acute /severe hypertension. Onion skin often : accompanied by deposits of fibrinoid and acute necrosis necrotizing arteriolitis(kidney)
Vasculitis
Inflammation of the walls of the vessels.
Vasculitis
Classification : direct infection: bacterial, rickettsial, spirochaetal, fungal, viral. Immunologic: immunecomplex mediated : SLE, RA, ANCA (antineutrophil cytoplasmic autoAb )mediated: Wegener granulomas,microscopic polyangiitis, ChurgStrauss syndrome direct antibody attack mediated: Goodpasture, Kawasaki (antiendothelial)
Vasculitis
Vasculitis
Vasculitis
Vasculitis
Thromboangiitis obliterans
Varicose veins
Pathogenesis: obese persons have greater tendency poor tissue support.
The most important factor is posture long periods of standing . Even in normal person simple orthostatic edema.
Other conditions : pregnancy, intravascular thrombosis, tumor mass. Microscopically : variation in thickness dilation and hypertrophy of smooth muscle and subintimal fibrosis, degeneration of elastic tissue, and spotty calcification in the media (phlebosclerosis).
Varices
Statis dermatitis.
Varicose ulcers.
Neoplasm
Benign :
hemangioma: Capillary, cavernous. lymphangioma: capillary, cavernous.
Neoplasm
Intermediate grade neoplasms.
Kaposi sarcoma.
Hemangioendothelioma Hemangiopericytoma.
Malignant neoplasm.
angiosarcoma.
Haemangioma
cavernous
capillary
Angiosarcoma
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