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Introduction
Vulva contains a variety of tissues and hence all types of tumours can occur in the vulva. b Many types have been recorded, both benign and malignant. b Vulval malignancies account for about 4% - 5% of all genital malignancies
b
1.7
per 1,00,000 females, the lesion is rare The distribution varies from 3.5 % amongst genital malignancy.
Multifocal Younger women Related to HPV infection VIN( vulvar intraepithelial neoplasia) Smoking
Keratinizing types
related to HPV infection, Others Obesity, hypertension, diabetes, nulliparity Condylomata accuminata( HPV 6,11), HSV-2 Syphilis & lymphogranuloma venerum. Chronic irritation of vulva by chemical or physical trauma, cervical neoplasia Poor hygiene, immunosuppression
Sites: common
is labia majora, clitoris, labia minora. Anterior 2/3rd commonly affected. Naked eye appearance Ulcerative: features are raised everted edges, sloughing base with surrounding induration. It is common Hypertrophic: overlying skin may be intact or ulcerates sooner or later. It is rare.
Squamous
cell cancer: Basaloid carcinoma, warty carcinoma, keratinizing types. Mitoses is noted in these malignancies Keratinization is seen
Microinvasive
squamous
carcinoma
2cm in diameter with 1mm
stromal invasion Invasion depth <1mm -inguinal LN metastasis : extremely rare Invasion depth >1mm - LN metastasis risk is more
Direct
Lymphatic
Hematogenous
Older
women: absent Young women: present, 29 years Pruritis vulvae: present Swelling with offensive discharge & bleeding: present Difficulty in urination: present Backache : present Pain : present
Vulval
inspection Fungating mass on vulva with sloughing base, irregular edges: present Foul smelling discharge, bleeds to touch: present PV: growth involves ant. & lateral vaginal wall PR: rectal mucosa free Inguinal lymph gland enlargement: left side lymphadenopathy.
Wedge
Condylomata
Uraemia Rupture
vessels sepsis
of femoral
Stage 0 (Carcinoma in Situ) Treatment of stage 0 may include the following: Wide local excision and/or laser therapy. Skinning vulvectomy with or without skin grafting. Simple vulvectomy. Topical chemotherapy.
Wide
local excision. Radical local excision with removal of nearby lymph nodes. Radical vulvectomy and either removal of nearby lymph nodes or radiation therapy to the lymph nodes. Radiation therapy.
Modified
radical vulvectomy and removal of nearby lymph nodes or radiation therapy to the lymph nodes. Radiation therapy to the area of surgery may also be given. Radiation therapy.
Modified
radical vulvectomy and removal of nearby lymph nodes, with or without radiation therapy. Radical vulvectomy and removal of nearby lymph nodes, with or without radiation therapy. Radiation therapy followed by surgery. Radiation therapy with or without chemotherapy.
Radical
vulvectomy and pelvic exenteration. Radical vulvectomy followed by radiation therapy. Radiation therapy followed by surgery, with or without chemotherapy. Radiation therapy with or without chemotherapy.
Lymphoscintigraphy
locate nodes
is used to
These days, Separate incision -> POP 1-2day : ambulation DVT prevention Subcutaneous heparin pneumatic calf compression Frequent dressing Suction drainage of
Chronic
hernia (uncommon)
Depression,
Chronic
pain related to vulval growth, metastases Imbalancd nutrition less than body requirement related to less food intake Impaired urinary elimination related to closure of urethra by vulval growth Anxiety and fear related to outcome of the disease process
Knowledge
deficit related to disease process, outcome and management Ineffective individual coping related to disease condition Interrupted family process related to hospitalization Decisional conflict related to treatment option Anticipatory grieving relatd to potential loss of life Risk for infection related to open vulval growth, poor nutritional status.
Sheth SS. Essentials of Gynecology. 1stedition. New Delhi: Jaypee bros;2005 Mukherjee GG. Current obstetrics and gynecology. 1st edition. New Delhi: Jaypee bros medical publishers.2007. Varney H, Kriebs JM , Gregor CL. Varneys textbook of midwifery . 4th edition. New Delhi: Elsevier; 2005 Padubidri V.G, Daftary SN. Hawkins and burns- Shaws text book of gynecology.14th edition. Noida: Elsevier;2008 Kumar P, Malhotra N. Jeffcoats principles of gynecology. 7th edition. New Delhi: Jaypee Bros Medical Publishers;2008 Dutta DC. Text book of gynecology.4th edition. Kolkata: New central book agency;2007 http://www.nlm.nih.gov/medlineplus/vulvarcancer.html