COURSE DESCRIPTION

TIN 330 Bioindustrial Technology 3(2-3)

Course Description
Knowledge on cultivation process design which covers environmental factors in effect of microbial growth and enzymatic processes , bioreactors and instrument, cultivation process, downstream process and techno-economy bioprocess aspects. Holistic understanding on bioindustrial technology and how to develop bioindustrial product

Textbook

Aiba,S., A.E humprey, dan N.F. Milis.1973. Biochemical Engineering., Second Edition. Academic Press, New York Belter, P.A.,E.L. Cutsler dan H.Wei-Shou.1988. bioseparations : Downstream Processing for Biotechnology. A Wiley-interscience Publ., New York crueger, W and A. Crueger.1984. Biotechnology : A Textbook of Industrial Microbiology. Science tech., Inc., Madison Rehm, H.Z and G. Reed.1985. Biotechnology Vol 9.1995. Biotechnology : Enzyme, Biomass, Food and Feed, VCH Verlagsgeselshaft mbH,Weinheim Scragg, A.H.1991.Bioreactors in Biotechnology : A Practical Approach>Ellis Horword, New york Stanbury, P.F and A. Whitaker.1989.Principles of Fermentation technology. Pergamon Press.Oxford Wang, D.I., C.L.Cooney, A.L.Demain,P.Dunnil,A.E.humprey and M.D.Lilly.1979.Fermentation and Enzyme Technology.John Willey and Sons, new york

Textbook

Prave,P.,U.Faust,W.Sittg and D.A.Sukatsch.1987.Fundamentals of Biotechnology.VCH Verlagsgeselshaft mbH,Weinheim Bailley,J.E and D.F.Ollis.1986. Biochemical Engineering Fundamentals.Second Edition.McGraw-Hill Co., New York Chaplin,M.F and C.Bucke.1990. Enzyme Technology>Cambridge university Press, Cambride Demain,A.L. and N.A. Solomon.1986.Manual of Industrial Microbiology and Biotechnology. American Societyfor Microbiology.Washington Margaritis,A. and J.B. Wallace.Novel Bioreactor System and their Application.J.of Biotechnology.May,1984 Pirt,S.J.1985.Principles of Microbe and Cell Cultivation.blackwell Sci., Oxford Rehm,H.Z and G.Reed.1985.Biotechnology vol 2 : Fundamentals of Biochemical Engineering. VCH Verlagsgeselshaft mbH,Weinheim

Other references
L.Hartoto and I.Sailah.1992. Sistem Bioreaktor.Pusat Antar Universitas Bioteknologi.IPB, Bogor Judoamidjojo,R.M.,E.G.Said dan L.Hartoto.1989.Biokonversi. Pusat Antar Universitas Bioteknologi,IPB Mangunwidjaja,D. and A.Suryani.1994. Teknologi Bioproses. Penebar Swadaya, Jakarta

Course Outcomes

Understand scope range and how important to study bioindustrial technology Understand cultivation technique and downstream application on bioindustry Understand type of bioreactor and its application to many production process Understand free enzyme application and immobile to many production process Understand many kind of plants and animal cell and its application to bioindustry Understand techno-economy aspects in bioindustry Understand microbes application for many kind of products made with optimal cultivation condition, bioreactor uses and efficient downstream process Collaborate in a team work Demonstrate effective communication orally and in writing

Lecturer Team
1. MRH (Mulyorini Rahayuningsih) coordinator 2. IKS (Khaswar Syamsu) 3. PUR (Purwoko) laboratory practices coordinator 4. Rini Purnawati and Egnawati Sari laboratory practices

Major Topics Covered in the Course

Week 1 2-3 4 5 6 Major Topics Introduction Cultivation technique and downstream application process Type of bioreactors and example application to many processes Scale up of bioprocess Free and immobile enzyme application to many production processes Lecturer IKS IKS IKS IKS IKS

7
10 11 12 13 14 15

Bioetanol production technology

Biopolymer (gum xanthan, pullulan, gellan, dextran, etc ) production technology

IKS
MRH MRH MRH MRH MRH MRH

ARA production technology Bioinsecticides, microbial vitamins production technology Organic acids production technology Microbial Enzymes production technology Antibiotics and vaccines production technology

16

Techno economy aspects in bioindustry

MRH

Laboratory practices
Week 1 Topics GLP in Microbiology Lab Lecturer PUR

2-3
4-5 6-7 10-11 12-13-14 15-16

Kinetics of Enzymatic Processes

Production of Lipase Enzymes

PUR
PUR

Production of bioetanol : Immobilized cells and free cells PUR Production of citric acid : submerged cultivation and solid substrates cultivation Bioinsecticides production semi solid and submerged cultivation Scale up technique MRH MRH IKS/Rini P

Assessment
Mid exam (UTS ) 30 % Final exam (UAS) 30 % Laboratory Practices (performance and report) 30 % Paper 10 %