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OPTIC NEURITIS IN ASSOCIATION WITH MULTIPLE SCLEROSIS

HANINA YUTHI M 030.09.106

MULTIPLE SCLEROSIS

Multiple Sclerosis

Multiple sclerosis (MS) is remittent chronic disease characterized by demyelinating plaques, spread through cerebral white matter lesions.

Etiology ?

Risk factors?

Symptoms

OPTIC NEURITIS

OPTIC NEURITIS
Optic neuritis is an inflammation of the optic nerve a bundle of nerve fibers located in in the back of eye that transmits visual information captured by the retina into the brain

Sign and symptoms

OPTIC NEURITIS IN ASSOCIATION WITH MULTIPLE SCLEROSIS

Research on optic neuritis related to MS


ON first affects people aged between 15 and 50 years of age. Studies indicate that more than 50% of patients will convert to MS within 15 years. However, the results of individual studies vary greatly, coming up with conversion rates from 33% to 71% and higher. Between 30 to 40 percent of people with MS will have an episode of ON at some point. ON is often the first symptom that leads to a diagnosis of MS. In fact, between 50 and 60 percent of people who have an isolated episode of optic neuritis go on to develop MS

Study of ON in MS have been performed abroad. One of the study show that ON is the most common symptom at onset of MS and presents unilaterally (in one eye only) in 70% of cases. The minority (35%) of children presenting with ON go on to develop MS.

The study was performed by PN Shams and GT Plant from London, UK. The result showed that Acute demyelinating optic neuritis is the initial presentation in approximately 20% of cases of multiple sclerosis (MS) and is characterized by unilateral, subacute, painful visual loss without systemic or neurological symptoms. The 15-year risk of developing MS in the ONTT (ON Treatment Trial) was 25% with no lesions, but 75% with one or more lesions.

Treatment and Prevention


Prednisone and methylprednisolo ne I.V

No treatment, counseling

Treatment of ms

Plasmapheresis, Interferon Beta I.V Ig

Assistive devices, physical therapy a healthy lifestyle

lifestyle modification

Conclusion Optic neuritis in MS is caused by a lesion and the related inflammation on the optic nerve.It was concluded that neuritis retrobulbar is highly associated with multiple sclerosis.

It is important for early ON diagnosis, clinical follow-up and prognosis to acquire as more information as we can to achieve better outcome.

1. Martinelli V, Rodegher M, Moiola L, Comi G. Neurol. Sci., 25. 2004; 350.

2. Lema Bouzas M,. Dapena Bolauo MD. Med. Clin., 123. 2004; 743.
3. Balcer LJ. Clinical practice. Optic neuritis. N Engl J Med 2007; 354-1273. 4. Frohman EM, Frohman TC, Zee DS, et al. The neuro-ophthalmology of multiple sclerosis. Lancet Neurol 2007; 4-111. 5. Arnold AC. Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 2007; 139-1101. 6. Optic Neuritis Study, Group. "Multiple Sclerosis Risk after Optic Neuritis: Final Optic Neuritis Treatment Trial Follow-Up". Arch. Neurol. 2008; 65 (6): 72732. 7. Optic neuritis. Ferri's Clinical Advisor 2009, 1st ed. Available at: http://www.allaboutvision.com/conditions/optic-neuritis.htm. 2011.

8. Optic neuritis. Conn's Current Therapy 2008, 60th ed. Available at : http://www.allaboutvision.com/conditions/optic-neuritis.htm. 2011 9. Multiple Sclerosis. Definition and Causes. Available at : http://www.multsclerosis.org/howms.html. 2008 10. Compston A, Coles A. "Multiple sclerosis". Lancet 372 (9648): 2008; 150217. 11. Calabresi P. Multiple sclerosis and demyelinating conditions of the central nervous system. In: Goldman L, Ausiello D, eds. Cecil Medicine . 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 436. 12. Pittock SJ, Lucchinetti CF. "The pathology of MS: new insights and potential clinical applications". Neurologist 13 (2): 2007; 4556. 13. Graham, Ken, and Joseph Rizzo. "A Review of Optic Neuritis." Digital Journal of Ophthalmology 5. Digital Journal of Ophthalmology. 2004. 14. Ropper AH, et al. Disturbances of vision. In: Ropper AH, et al. Adams and Victor's Principles of Neurology. 9th ed. New York, N.Y.: McGraw-Hill Medical; 2009. http://www.accessmedicine.com/content.aspx?aID=3631567. 2011.

15. Clark D, et al. Optic neuritis. Neurologic Clinics. 2010; 28:573. 16. Osborne B. Optic neuritis: Pathophysiology, clinical features, and diagnosis. http://www.uptodate.com/home/index.html. 2010 17. Optic neuritis in Multiple Sclerosis : Pathophysiology. Available at : http://www.multsclerosis.org/opticneuritis.html. 2012

18. Randall T. Shapiro. Managing the Symptoms of Multiple Sclerosis (5th ed.). New York: Demos Medical Publishing, 2007.
19. Optic Neuritis Study Group.Visual function 15 years after optic neuritis: a final follow-up report from the Optic Neuritis Treatment Trial. Ophthalmology 2008; 115: 10791082. 20. Kidd DP: Inflammatory optic neuropathies associated with multiple sclerosis. In: Neuroophthalmology (Kidd DP, Newman NJ, Biousse V, eds). Boston: Butterworth Heinemann 2008; pp153190. 21. Costello F, Coupland S, Hodge W et al. Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol 2006; 59: 963969.

22. Fisher JB, Jacobs DA, Markowitz CE et al. Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmology 2006; 113: 324332. 23. Henderson AP, Trip SA, Schlottmann PG et al. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain 2008; 131: 277 287.

24. Bhatti MT; Group ONS. The final 15-year follow-up report on the neurological outcome of the Optic Neuritis Treatment Trial. 34th Annual Meeting of the North American NeuroOphthalmology Society (NANOS), Orlando, USA, 2008.
25. Study about optic neuritis. American Academy of Neurology. Available at : http://www.neurology.org/content/29/2/208.short. 2011 26. Treatment for optic neuritis related to multiple sclerosis. Food and Drug Administration Prescribing Information. Avaiable at : http://www.medicinenet.com/optic_neuritis/index.htm. 2011.