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HANINA YUTHI M 030.09.106


Multiple Sclerosis

Multiple sclerosis (MS) is remittent chronic disease characterized by demyelinating plaques, spread through cerebral white matter lesions.

Etiology ?

Risk factors?



Optic neuritis is an inflammation of the optic nerve a bundle of nerve fibers located in in the back of eye that transmits visual information captured by the retina into the brain

Sign and symptoms


Research on optic neuritis related to MS

ON first affects people aged between 15 and 50 years of age. Studies indicate that more than 50% of patients will convert to MS within 15 years. However, the results of individual studies vary greatly, coming up with conversion rates from 33% to 71% and higher. Between 30 to 40 percent of people with MS will have an episode of ON at some point. ON is often the first symptom that leads to a diagnosis of MS. In fact, between 50 and 60 percent of people who have an isolated episode of optic neuritis go on to develop MS

Study of ON in MS have been performed abroad. One of the study show that ON is the most common symptom at onset of MS and presents unilaterally (in one eye only) in 70% of cases. The minority (35%) of children presenting with ON go on to develop MS.

The study was performed by PN Shams and GT Plant from London, UK. The result showed that Acute demyelinating optic neuritis is the initial presentation in approximately 20% of cases of multiple sclerosis (MS) and is characterized by unilateral, subacute, painful visual loss without systemic or neurological symptoms. The 15-year risk of developing MS in the ONTT (ON Treatment Trial) was 25% with no lesions, but 75% with one or more lesions.

Treatment and Prevention

Prednisone and methylprednisolo ne I.V

No treatment, counseling

Treatment of ms

Plasmapheresis, Interferon Beta I.V Ig

Assistive devices, physical therapy a healthy lifestyle

lifestyle modification

Conclusion Optic neuritis in MS is caused by a lesion and the related inflammation on the optic nerve.It was concluded that neuritis retrobulbar is highly associated with multiple sclerosis.

It is important for early ON diagnosis, clinical follow-up and prognosis to acquire as more information as we can to achieve better outcome.

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