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FAKULTAS KEDOKTERAN
UNIVERSITAS METHODIST INDONESIA
MELANOMA
RADIAL GROWTH PHASE MELANOMA (SUPERFISIAL SPREADING) the very beginning of malignant melanoma.
VERTICAL GROWTH PHASE MELANOMA
PATHOGENESIS
Arise from neoplastic transformation of normally epidermis melanocytes proliferation superficial spreading invasive metast to lymphatic/hematogen
CLINICAL FEATURE
MACROSCOPICALLY
Early melanoma radial growth phase Slightly elevated & palpable border Variably colored some parts unusually black / dark brown Lighter brown shade mingled with pink & light blue tints Entire lesion purely dark brown occasionaly
MICROSCOPICALLY
Large epitheloid melanocytes dispersed in nests / as individual cells entire thickness of epidermis Brisk lymphocytis response May be only in epidermis (in situ) Focal extension papillary dermis is rule Grow in all directions Dermal mitoses (-)
1-2 years of radial growth character of growth change focally Focal mitotic activity (+) Grow as spheroidal nodules Expand rapidly in surrounding papillary dermis Net direction growth perpendicular
Cells differ in appearance little / no pigment ; radial : melanotic Cellular aggregate characteristic vertical Larger cluster cells extend into lower half reticular dermis Host cellular immune response (-)
TYPES :
1. Metastatic Melanoma 2. Nodular Melanoma - Rarest form - Radial growth phase (-) - Malignant character expressed in initial lesion
3. Lentigo Malignant Melanoma - Usually in fair, elderly & whites = Hutchinsons freckle 4. Acral Lentiginous Melanoma - Most common form dark-skinned - Limited to palm, sole & subungual region
PROGNOSIS
1.
2. 3.
4.
5. 6. 7.
Type of melanoma Lentigo better Depth of invasion Breslows thickness Level of invasion Clark Number of inflammatory cells Clinical Stage Sex : female better Regression (+) poorer prognosis
Lentigo maligna
Nodular melanoma
Nodular melanoma
Nodular melanoma
SKIN CARCINOMA
1.
2.
PATHOGENESIS
Develop on sun damaged skin fair skin & freckles Fingers & dorsum of hand Derived from pluripoten cells of basal layer Differentiated along skin appendage lines
CLINICAL FEATURE
Pearly papule prototypic lesion Rodent ulcer small crater in center of pearl Superficial BCC scaly, red, sharply demarcated plaque Morphea-like BCC ill defined, pale, firm, scarlike tumor Pigmented BCC grossly resembles malignant melanoma
PATHOLOGY
Multiple nests of deeply basophilic epithelial cells attached to epidermis protude into papillary dermis Central part compose of closely packed keratinocytes Nuclei deeply basophilic surround by small rim cytoplasm Periphery nests composed of an organized layer of polarized, columnar keratinocytes
Cancer of epidermis whose cells resemble differentiated keratinocytes Incidence : second only to BCC Caused by UV, radiation, chemical carcinogens, HPV Often originates in actinic keratoses
PATHOGENESIS
Related to UV light Chronic scarring process > metastase than solar-related SCC
CLINICAL FEATURE
PATHOLOGY
Composed of tumor cells mimic epidermal stratum spinosum extend into subjacent dermis Variably thickened & parakeratotic Atypia basal keratinocyte (+)
Squamous cell carcinoma in situ, medium power. The normal maturation pattern of keratinocytic apithelium is disturbed, imparting a windblown look to the neoplastic epithelium. There is a parakeratotic scale
Squamous cell carcinoma in situ, high power. The lesional cells exhibit nuclear attributes of malignancy-enlargement, hyperchromatism, pleomorphism, and dyskeratosis