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Vytorin
Pete was glad to finally be home. Hed been gone since 8 oclock this morning - first to classes all day and then straight to his job at Dillards. Now it was 8 pm. He walked into his apartment and threw his backpack on the floor. Whew! He was tired and hungry! He found some hot pockets in the freezer and threw two in the microwave before he slumped on the couch and turned on the TV. Another one of those annoying drug company commercials! This one was about some drug called VytorinTM. As the microwave beeped that his dinner was ready, Pete watched the commercial and laughed at all of the people who resembled what they ate. He wondered.do I look like a Hot Pocket?
As Pete wolfed down his dinner, he was curious. How much cholesterol was in a hot pocket anyway? He grabbed the box from the trash can and read the nutrition label on the back.
Steak n Shake Frisco Melt 1173 calories 93 g of total fat French fries 211 calories 10g total fat Vanilla shake 654 calories 21 g total fat
47 g total fat
CQ#2: What percent of your average daily food intake is fresh fruits and/or vegetables?
A. 0% B. 10% C. 25 % D. 50% or greater
Fat? Saturated fat? Are these different than cholesterol? Pete kept searching.
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CQ#4: Pete normally consumes ~ 2000 calories per day. What % of his total daily caloric intake is coming from the two Hot Pockets? What % of his total daily calories is coming from the fat in his two Hot Pockets? A. ~ 30%; 5% B. ~ 30 %; 11% C. ~ 50 %; 20% D. ~ 60 %; 11%
Is Pete meeting AHA recommended guidelines for fat consumption?
(limit your fat intake to no more than 30% of your daily calories)
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Cholesterol is a Lipid
Lipids are the group of biological macromolecules that have a major hydrocarbon component and are mostly nonpolar and hydrophobic. Functionally, lipids are important in cell membrane structure and in energy production. There are three main families of lipids: Steroids Fats Phospholipids
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Steroids
Typically have a core structure of four fused carbon rings Cholesterol is an example. Many hormones and vitamins are steroids.
Cholesterol
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CQ#5: Which of the following is the best explanation for why vegetable oils are liquid at room temperature?
A. Vegetable oils are saturated fatty acids that do not pack together efficiently and therefore have a low melting point. B. Vegetable oils are saturated fatty acids that pack together very efficiently and therefore have a low melting point. C. Vegetable oils are unsaturated fatty acids that do not pack together efficiently and therefore have a low melting point. D. Vegetable oils are unsaturated fatty acids that pack together very efficiently and therefore have a low melting point.
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Phospholipids
Phospholipids consist of a 3-carbon glycerol linked to a negatively charged phosphate group, and two fatty acids. Phospholipids are a major component of cell membranes due to their amphipathic nature. Amphipathic molecules have a nonpolar region (hydrophobic) and a polar region (hydrophilic).
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Pete was beginning to understand a little bit about cholesterol and fats. But he still didnt understand: why were they so unhealthy? And if they are unhealthy, why do we even need cholesterol and fat?
In small groups, develop an answer. What would you tell Pete?
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Pete learned that your body needs some cholesterol. In addition to being a component of cell membranes, cholesterol is also used to make hormones, vitamin D, and substances that help you digest foods. Your liver makes all the cholesterol your body needs. And excess cholesterol and fat in our bodies is dangerous. It often means you are overweight, and it can damage your vascular system. The amount of cholesterol a person produces varies depending upon their genetic makeup.
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Since cholesterol is hydrophobic (water fearing) and blood is hydrophilic (water loving), the two do not mix. Cholesterol is carried through the bloodstream in protein packages called lipoproteins, made up of lipid on the inside and protein on the outside. Two kinds of lipoproteins carry cholesterol throughout your body.
- High density lipoproteins (HDL) - Low density lipoproteins (LDL)
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Pete was beginning to get the idea. Low cholesterol/LDL levels in your blood help keep you healthy by preventing heart attacks and strokes. Therefore, maybe eating foods that are low in cholesterol may ultimately be able to lower your risk for these diseases.
But what would a normal blood cholesterol level be?
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Lipoprotein Profile
Cholesterol levels are measured in milligrams (mg) of cholesterol per deciliter (dL) of blood.
Desirable or optimal levels for adults with or without existing heart disease are: Total cholesterol: Less than 200 mg/dL. Low Density Lipoprotein (LDL) cholesterol: Less than 100 mg/dL. High Density Lipoprotein (HDL): 40 mg/dL or higher. Triglycerides: Less than 150 mg/dL.
The National Cholesterol Education Program recommends that healthy adults over 20 years of age have their cholesterol levels checked once every 5 years.
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CQ#7: Review Petes lipid profile results below. What should Pete know?
A. Pete has acceptable cholesterol levels. B. Pete has borderline high cholesterol and high LDL levels; however the fact that his HDL is elevated is a benefit to him. C. Pete has high cholesterol and HDL levels yet the fact that his LDL is elevated is a benefit to him.
Total cholesterol: 233.4 mg/dl HDL: 55 mg/dl LDL: 122 mg/dl Triglycerides:125 mg/dl
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Pete was surprised. He was young, relatively active (he walked to class everyday at least), was only a little overweight, and he thought he ate pretty well. But apparently his body did not think so.
His doctor suggested three things to help lower his blood cholesterol: Reduce the amount of saturated fat and cholesterol in his diet. Lose some weight. Losing weight can help lower your LDL and total cholesterol levels, as well as raise your HDL and lower your triglyceride levels. Be physically active for at least 30 minutes most, if not all, days.
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So if KFC already cooks their chicken in vegetable oil, whats the problem?
Ok, doc. No more burgers and fries. But I dont get it. Ive been reading a lot on the internet and I know that oil, like corn oil, is not saturated. Its unsaturated. So why are things cooked in margarine also bad? Isnt margarine made from corn oil? Yes, youre right, Pete, his doctor said. There is another type of bad fat out there. Its called a trans fat. Lots of trans fats exist in products like margarine.
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Resolution
Wow! Pete never knew that food could be so complicated. But now it all makes sense. He didnt think he ate a lot of high cholesterol foods, but he did eat a lot of processed snacks and fast food cookies, french fries foods with high trans fat content. Pete decided it was time to really start paying more attention to what he ate, especially with regard to fats and cholesterol, and to exercise. Its never to early to Face the Fats.
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Postscript
Are all partially hydrogenated products bad? NO! Recent changes in the food industry with regard to processing of oils results in partially hydrogenated products with minimal trans fat content. A recent publication in Ann Nutr Metab 2009; 54 (Suppl.1):15-24 states that:
margarines and cooking products, and to a lesser extent dressings, have been adapted to contain less trans fatty acids (TFA), less saturated fatty acids (SFA) and more essential (polyunsaturated, PUFA) fatty acidsBy blending vegetable oils rich in the essential PUFAs a-linolenic acid (w-3) or linoleic acid (w-6), margarines and dressings with both essential fatty acids present in significant quantities can be realized. In addition, full hydrogenation and fat rearrangement have enabled the production of costeffective margarines virtually devoid of TFA and low in SFA. Dietary surveys indicate that vegetable oils, soft margarines and dressings are indeed often important sources of essential fatty acids in people's diets, whilst providing negligible amounts of TFA and contributing modestly to SFA intakes.
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Image Credits
Slides 3, 4 and 9 right Description: Image of the nutritional data from a cheeseburger Hot Pockets. Slide 7 lower right Description: Fruits and vegetables Source: Wikimedia commons Link: http://upload.wikimedia.org/wikipedia/commons/b/bd/Shukaku_no_aki_autumn_fruit_vegetables.JPG Permission: Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation Slide 8 lower right Description: Oils Source: National Institutes of Health Link: http://www.nlm.nih.gov/medlineplus/images/oliveoil.jpg Permission: Open source free access; work of U.S. Federal government under the terms of Title 17, Chapter 1, Section 105, of the U.S. Code. Slide 12 right Description: Molecular structure of cortisol and Vitamin D Source: Wikimedia Commons Link: http://commons.wikimedia.org/wiki/File:Steroid_hormones,_cortisol_and_Vitamin_D3.jpg Permission: This image of a simple structural formula is ineligible for copyright and therefore in the public domain, because it consists entirely of information that is common property and contains no original authorship. Slide 12 right (lower) Description: Cell membrane structure Source; Wikimedia Commons Link: http://commons.wikimedia.org/wiki/File:Cell_membrane_detailed_diagram_en.svg Permission: This image has been released into the public domain by its author, LadyofHats.
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Slide 13 right Description: Molecular structure of a triglyceride backbone Source: Wikimedia Commons Link: http://commons.wikimedia.org/wiki/File:Triglyceride-2D-skeletal.png Permission: This image has been released into the public domain by its author Slide 14 right top Description: Space filling model of myristic acid Source: Wikimedia commons Link: http://commons.wikimedia.org/wiki/File:Myristic-acid-3D-vdW.png Permission: image has been released into the public domain by its author Slide 14 right middle Description: Molecular structure of myristic acid Source: Wikimedia commons Link: http://commons.wikimedia.org/wiki/File:Myristic_acid.svg Permission: This image is ineligible for copyright and therefore in the public domain, because it consists entirely of information that is common property and contains no original authorship Slide 14 right middle Description: Space filling model of oleic acid Source: Wikimedia commons Link: http://commons.wikimedia.org/wiki/File:Oleic-acid-3D-vdW.png Permission: This image has been released into the public domain by its author Slide 14 right bottom Description: Molecular structure of oleic acid Source: Wikimedia Commons Link: http://commons.wikimedia.org/wiki/File:Oleic-acid-skeletal.svg Permission: This image has been released into the public domain by its author Slide 16 right (left hand side) Description: Molecular structure of phosphatidylcholine Source: Wikimedia commons Link: http://commons.wikimedia.org/wiki/File:Phosphatidylcholine.png Permission: Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation
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Slide 16 right (right hand side) Description: Structure of phospholipids in solution Source: Wikimedia commons Link: http://commons.wikimedia.org/wiki/File:Phospholipids_aqueous_solution_structures.svg Permission: This image has been released into the public domain by its author, LadyofHats. Slide 20 right Description: lipoprotein structure Source: "lipoprotein." The Oxford Dictionary of Sports Science . Oxford University Press, 1998, 2006, 2007. Answers.com 21 Jul. 2009. http://www.answers.com/topic/lipoprotein Link: http://content.answers.com/main/content/img/oxford/Oxford_Sports/0199210896.lipoprotein.1.jpg Permission: Slide 22 right Description: Artherosclerosis Source: National Heart Lung Blood Institute of the NIH Link: http://www.nhlbi.nih.gov/health/dci/Diseases/Hbc/HBC_WhatIs.html Permission: Open source free access; work of U.S. Federal government under the terms of Title 17, Chapter 1, Section 105, of the U.S. Code. Slide 30 right Description: Krispy Kreme donuts Source: Wikimedia Link: http://upload.wikimedia.org/wikipedia/commons/b/b6/Krispy_Kreme_donut_assortment.JPG Permission; Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation Slide 38 right Description: HMG-CoA reductase pathway (cholesterol) Source: Wikimedia Link http://commons.wikimedia.org/wiki/File:HMG-CoA_reductase_pathway.png Permission: Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation
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