Académique Documents
Professionnel Documents
Culture Documents
Chapter 8
2.
3. 4. 5. 6. 7.
Differential diagnoses
Main diagnosis
Triage
Emergency signs (Ref. p. 2, 6) Obstructed breathing Severe respiratory distress Central cyanosis Signs of shock Coma Convulsions Severe dehydration Priority signs (Ref. p. 6) Tiny baby Temperature Trauma Pallor Poisoning Pain (severe) Respiratory distress Restless, irritable, lethargic Referral Malnutrition Oedema of both feet Burns
Emergency treatment
History
Thomas was well until 5 months of age. Since then he had two episodes of pneumonia that needed several days of hospital treatment with intravenous antibiotics. Since the first admission he had had poor weight gain. He has not been able to eat or drink much in the last week because of mouth sores, which had been there for 4 weeks
History (continued)
Thomas had had frequent episodes of watery diarrhoea since he was 5 months old. Each episode of diarrhoea lasted for 10-14 days, mostly watery diarrhoea with some mucus in the stool.
Nutrition history
Thomas is still breastfed. He was exclusively breastfed till 5
months of age and then weaning food was introduced. The weaning food mainly contained rice, vegetables, and occasionally meat. Not feeding well in last week because of mouth sores
Family history
Thomas is the second child of his parents. His father is 24 years old and is a truck driver. His mother is 20 years old and she is a housewife. His 18 month-old sister is healthy. They live in a small rented room.
Examination
Thomas was alert and active but miserable. He was a little pale and had muscle wasting, but was not cyanosed or jaundiced. He had bilateral enlarged inguinal, axillary and submandibular nontender lymph nodes, all measuring 1-1.5cm. Vital signs: temperature: 38.50C, pulse: 120/min, RR: 40/min, Weight: 6.4 kg Ear-Nose-Throat: white plaques over the buccal mucosa, gums and posterior oropharynx Skin: dry, flaky skin Chest: no respiratory distress, clear to auscultation Cardiovascular: both heart sounds were audible and there was no murmur Abdominal examination: liver was palpable 3 cm below the right costal margin and spleen was enlarged 5 cm below the left costal margin Neurology: conscious; no neck stiffness
Differential diagnoses
List possible causes of the illness Main diagnosis Secondary diagnoses Use references to confirm
Differential diagnoses
Recurrent infections Oral thrush due to antibiotics HIV Congenital immune deficiency
Recurrent infections
(Ref. p. 226-227)
Oral thrush without antibiotic treatment, or lasting over 30 days despite treatment Chronic parotitis Lymphadenopathy and hepatomegaly Persistent and/or recurrent fever Herpes zoster Dermatitis Chronic suppurative lung disease Malnutrition Persistent diarrhoea
Investigations
FBE Ulcer swab HIV antibody test After counseling the parents and seeking consent Interpretation of a positive test Effect of age (antibody and viral particle assay) Need for repeat test for confirmation
Investigations (continued)
Full blood count: - Haemoglobin: - Platelets: - WCC: - Neutrophils: - Lymphocytes: - Monocytes: 8.9 g/l (105-135) 255 x 109/l (150 400) 14.6 x 109/l (6 18.0) 12.2 x 109/l (1.0 8.5) 1.4 x 109/l (4.0 10.0) 1.0 x 109/l (0.1 1.0)
Investigations (continued)
Thomas, his parents and his elder sisters (Rachel) HIV status were tested after the obligation to maintain confidentiality was assured. (Ref. p. 228).
The parents were encouraged to have a HIV test and the implications of the diagnosis were explained to them.
Thomas, his mother and father had positive HIV antibody test by ELISA assay. Rachel had a negative HIV antibody test.
Diagnosis
Summary of findings: History: persistent diarrhoea Examination: recurrent infection, oral thrush, generalised lymphadenopathy, hepatosplenomegaly Blood examination shows mild anaemia, lymphopenia Chest X-ray: bilateral lymphadenopathy HIV antibody test by ELISA assay: positive
What stage of the disease is Thomas at? see Table 22, p. 231
Antiretroviral treatment
There are three main classes (Ref. p. 234): Nucleoside reverse transcriptase inhibitors AZT (zidovudine), lamivudine, stavudine, didanosine, abacavir Non-nucleoside reverse transcriptase inhibitors Nevirapine, efavirenz Protease inhibitors: Nelfinavir, lopinavir/ritonavir, saquinavir
Usually two NRTIs plus one NNRTI
Trimmune
Access to treatment needs to be ensured for other family members as well High level of compliance and close follow-up are necessary
(Ref. p. 235)
ART Treat Treat Treat
Treat only where CD4 available and child: <18 month and CD4 <25% 18-59months and CD4 <15% >5 years and CD4<10%
Treatment (continued)
Oral thrush
Nystatin / ketaconazole (gentian violet) (Ref. p. 246)
Supportive care
Nutrition:
Nasogastric feeds with breast milk Multivitamins, vitamin A, zinc
Immunization:
Asymptomatic HIV infection: give all vaccines Symptomatic HIV infection (clinical AIDS): give all vaccines except BCG, measles and yellow fever (Ref. p. 240)
Prophylaxis:
Cotrimoxazole
Consider isoniazid
Follow-up
HIV-infected children should, when not ill, attend MCH clinics like other children. In addition they need regular clinical follow-up at first-level facilities several times a year to monitor: Clinical condition Neurological development Growth and nutrition Immunization status Social support for the family Psychological well being
Summary
The management of children with HIV infection is mostly similar to that of other sick children
Antiretroviral treatment has improved the lives of many HIV affected children Cotrimoxazole prophylaxis is indicated at all ages Consider INAH prophylaxis
Quality and duration of life can be improved with prompt treatment of inter-current infections and nutrition support
Effective and inexpensive prevention of parent-tochild transmission is available
Prevention
Prevention of Parent-to-child-transmission (PPTCT): Pre-test counseling Screening at antenatal care
Post-test counseling
Effective drug regimens (evolving) Breast feeding counseling
Contraception