WARM-UP #7

DNA (Deoxyribonucleic Acid)

Genetic material of cells… • GENES – units of genetic material that CODES FOR A SPECIFIC TRAIT • Called NUCLEIC ACIDS • DNA is made up of repeating molecules called NUCLEOTIDES .

G.DNA Nucleotide Phosphate Group O O=P-O O 5 CH2 O N C4 Sugar (deoxyribose) C1 Nitrogenous base (A. or T) C3 C2 . C.

described the DNA molecule from Franklin’s X-ray. (1953) . (1952) C.A HISTORY OF DNA SEE p. Rosalind Franklin .X-ray photo of DNA. 292-293 • Discovery of the DNA double helix A. Watson and Crick . Frederick Griffith – Discovers that a factor in diseased bacteria can transform harmless bacteria into deadly bacteria (1928) B.

Watson & Crick proposed… •DNA had specific pairing between the nitrogen bases: ADENINE – THYMINE CYTOSINE .GUANINE •DNA was made of 2 long stands of nucleotides arranged in a specific way called the “Complementary Rule” .

T.G or C) “Legs of ladder” Phosphate & Sugar Backbone .DNA Double Helix “Rungs of ladder” Nitrogenous Base (A.

DNA Double Helix 5 O 3 3 P 5 4 3 2 1 O O 1 5 P G C 2 3 4 P 5 O 5 T O A O 3 P 5 P 3 P .

Adenine (A) 2.Nitrogenous Bases • PURINES 1. Thymine (T) 4. Guanine (G) A or G • PYRIMIDINES 3. Cytosine (C) T or C .

Chargaff’s Rule • Adenine must pair with Thymine • Guanine must pair with Cytosine • Their amounts in a given DNA molecule will be about the same. T A G C .

BASE-PAIRINGS H-bonds G C T A .

.Genetic Diversity… • Different arrangements of NUCLEOTIDES in a nucleic acid (DNA) provides the key to DIVERSITY among living organisms.

The Code of Life… • The “code” of the chromosome is the SPECIFIC ORDER that bases occur. A T C G T A T G C G G… .

297 DNA is wrapped tightly around histones and coiled tightly to form chromosomes .See p.

298 . G-C •Each strand of the original DNA serves as a template for the new strand See p.DNA Replication • DNA must be copied • The DNA molecule produces 2 IDENTICAL new complementary strands following the rules of base pairing: A-T.

DNA Replication • Semiconservative Model: 1. and each functions as a template for synthesis of a new complementary strand. DNA Template New DNA . Watson and Crick showed: the two strands of the parental molecule separate. Parental DNA .

Replication Quiz A---? G---? C---? 2. Use the complementary rule to G---? create the complementary C---? strand: A---? G---? T---? 1. When does replication occur? T---? 3. Why is replication necessary? . A---? G---? A---? 4. Describe how replication works.

G---C 3. C---G 4. Why is replication necessary? G---C So both new cells will have the correct C---G DNA T---A 2.Replication Quiz A---T 1. When does replication occur? A---T During interphase (S phase). Describe how replication works. Use the complementary rule to A---T create the complementary strand: G---C T---A . A---T Enzymes unzip DNA and complementary G---C nucleotides join each original strand.

• 3 Nucleotides = a triplet or CODON (which code for a specific AMINO ACID) See p.(1961) Watson & Crick proposed… • …DNA controlled cell function by serving as a template for PROTEIN structure. .303 • AMINO ACIDS are the building blocks of proteins.

See p. .301 • Both DNA & RNA are formed from NUCLEOTIDES and are called NUCLEIC acids.DNA Transcription • DNA can “unzip” itself and RNA nucleotides match up to the DNA strand.

304-305 We will discuss details of this on a later date .DNA Translation • The cell uses information from “messenger” RNA to produce proteins See p.

1. identify the amino acids coded for by these codons: UGGCAGUGC . Why is translation necessary? Describe translation. 5. What are the main differences between DNA and RNA. Using the chart on page 303. 3. 2. 4. Transcription/Translation Quiz Why is transcription necessary? Describe transcription. 6.

3. RNA polymerase binds to DNA. Why is transcription necessary? Transcription makes messenger RNA (MRNA) to carry the code for proteins out of the nucleus to the ribosomes in the cytoplasm. 2. Why is translation necessary? Translation assures that the right amino acids are joined together by peptides to form the correct protein. then uses one strand as a template to assemble MRNA. . separates the strands.1. Describe transcription.

DNA has thymine. The cell uses information from MRNA to produce proteins. DNA has deoxyribose. What are the main differences between DNA and RNA. 6. DNA has 2 strands. Describe translation. RNA has ribose. RNA has uracil. 5. RNA has one strand.4. identify the amino acids coded for by these codons: UGGCAGUGC tryptophan-glutamine-cysteine . Using the chart on page 303.

000 books) .000 printed pages of 500 words each!!! (a library of about 1.AMAZING DNA FACTS… • DNA from a single human cell extends in a single thread for almost 2 meters long!!! • It contains information equal to some 600.

2. Hershey & Chase drew from their experiments. 3. List the conclusions Griffith & Avery.LET’S REVIEW DNA… LM p.44 1. 4. What are the 4 kinds of bases? . Summarize the relationship between genes & DNA. Describe the overall structure of the DNA molecule.

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