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MEDICAL IMPORTANCE OF CULICOIDES

A) Vector of pathogen(Disease transmitter)


1) Filarial infection(Mansonella spp ) They are transmitted by biting midge and generally regarded as non-pathogenic. Mansonella perstans is widely transmitted by Culicoides sp. in Africa & South America.

Mansonella streptocerca transmitted is restricted in Africa.

M. ozzardi transmitted by C. furens is restricted in South America and usually endemic to beach areas in Caribbean

-headache

Clinical fever headache eosinophilia rash pruritus abdominal pain arthralgia

picture :

2)Arbovirus(Oropouche fever)
They are transmitted by biting C.paraensis in Brazil, Trinidad and Colombia They are disease non fatal

Two distinct life cycle -epidemic urban cycle in which human is primary host -silent maintenance cycle in which forest animal are vertebrae host

Clinical picture
-headache -arthralgia -photophobia -myalgia -nausea -meningitis (rare)

B)Culicoides as etiological agent of disease(Causing disesase)


1)Bite : Annoyance and disturb sleep Allergic reactions( injection of saliva into skin) Skin lesion (inflammation and dermatitis)

Treatment
1) Filarial infection (Mansonella spp) M.perstants-Mebendazole 100 mg & Ivermectin 150ug/kg per single dose

M.streptocerca-Diethylcarbamazine

M.ozzardi Ivermectin 150ug/kg per single dose 2)Arbovirus( Oropouche virus) No specific therapy as no vaccine available

Control
Eradicate the population and their breeding place by suitable insecticide

Removal of vector larva habitat such as rotting cacao husks , trunk of felled banana plants

Repellent consist DEET (diethytoluamide)

Avoid of infestation by taking these precaution -Installation of window and door screen with a mesh size smaller

-Clothing impregnated with DEET or permethrin

2)Arbovirus (Oropouche fever) -refrain from sternuous activites -retire to bed -consult their physician

Reference
http://www.byron.nsw.gov.au/protect-yourself-from-biting-midges-sand-flies http://www.fehd.gov.hk/english/safefood/pest-post-midges.html http://en.wikipedia.org/wiki/Culicoides http://extension.entm.purdue.edu/publichealth/insects/bitingmidge.html http://entnemdept.ufl.edu/creatures/aquatic/biting_midges.htm http://www.cfsph.iastate.edu/BRMForProducers/English/RouteSpecificInformation /biting_midge_control.pdf http://www.public.health.wa.gov.au/cproot/2658/2/11177_BitingMidges_23658_ web.pdf http://books.google.com.eg/books?id=6R1v9ouaI4C&pg=PA169&lpg=PA169&dq=biting+midges+causing+diseases&source=bl&ot s=6l29irQwtR&sig=D-yvMtKqPYCbxeqtPcLoCaESTw&hl=en&sa=X&ei=ZIuzUrz9H_C00QXGgIEw&ved=0CFgQ6AE wCDgK#v=onepage&q=biting%20midges%20causing%20diseases&f=false http://books.google.com.eg/books?id=AB39e6KZ8MMC&pg=PA217&lpg=PA217&d q=mansonella+spp+in+human+by+culicoides&source=bl&ots=t0xa03vnDL&sig=nXi zDtF7P5ShtiJwxDmjlCli3sE&hl=en&sa=X&ei=kxG4UoG9DcSU0QXp_IGgDg&ved=0C GMQ6AEwCA#v=onepage&q=mansonella%20spp%20in%20human%20by%20culic oides&f=false

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