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Cardiac Disorders Cardiac Drugs

Shair Muhammad Hazara


BSN, M Sc BE [DUHS]

Cardiac Disorders
System = heart, blood vessels (arteries & veins), Blood Blood rich w/ O2 & nutrients moves through vessels called arteries to narrower arteriols to capillaries where the rich blood is absorbed by bodies cells & waste products are absorbed (CO2, urea, Cr, ammonia) deoxygenated blood returned to circulation via venules to veins for elimination through lungs & kidneys

Cardiac disorders
Heart = * 4 chambers - R & L atria, R & L ventricles * Blood from circulation to R atrium to R ventricle to pulmonary artery to lungs for gas exchange (CO2 & O2) to L atrium to L ventricle to aorta to systemic circulation Heart muscle = myocardium & surrounds the atria & ventricles

Cardiac Disorders
Pericardium = fibrous covering around the heart that protects it from injury & infection Endocardium = 3-layered membrane that lines the inner part of the heart chambers Valves = 4 - two atrioventricular (tricuspid & mitral) & 2 semilunar (pulmonic & aortic) control blood. flow between atria & ventricles & pulmonary artery & the aorta

Right Ventricle

Cardiac disorders
Conduction = Generated & conducted by the myocardium - usually * Originates in sinoatrial (SA) node - pacemaker atrioventricular (AV) node bundle of HIS purkinje fibers ventricular muscle tissue contraction from apex upward forcing blood to lungs & circulatory system

Cardiac disorders
Blood flow & Heart Rate (HR) * Ave. HR = 60 - 80 beats/min. (adult) * Ave. BP = 120/80 mm/Hg - resistance to blood flow through systemic arterial circulation Arterial BP determined by Cardiac Output (CO) = the volume of bld. expelled form the heart in 1 min. - calculated by mult. HR by stroke volume Ave. CO = 4 - 8 l/min.

Cardiac Disorders
Stroke Volume (SV) = amt. of bld ejected from the L vent. w/ each heart beat - Ave. = 70ml/beat - SV determined by 3 factors: -Preload - blood flow force that stretches the ventricle - Contractility - force of ventricular contraction - Afterload - Resistance to vent. ejection of blood caused by opposing pressures in aorta & systemic circulation Specific drugs can or preload & afterload, affecting both SV & CO - most vasodilators dec. preload & afterload a dec. in arterial pressure & CO

Cardiac Disorders Cardiac Glycosides


Digitalis - One of the oldest drugs (1200 AD) - Effective in treating congestive heart failure (CHF) - CHF = when the heart muscle weakens & enlarges loss of ability to pump blood through the heart & into the systemic circulation = heart failure (or pump failure) - peripheral & lung tissues become congested = CHF

Cardiac Disorders Cardiac Glycosides


CHF can be left sided or right sided Cardiac glycosides = digitalis glycosides - inhibits the Na - K pump inc. intracellular Ca cardiac muscle fibers contract more efficiently - Digitalis = 3 effects on the heart 1) + inotropic action (inc. myocard. contraction) 2) chronotropic action (dec. HR) #) - dromotropic action (dec. conduction of the heart cells

Cardiac Disorders Cardiac Glycosides


The inc. in myocardial contractility = inc. card., peripheral, & kidney function by inc. CO, dec. preload, improving bld flow to periphery & kidneys, dec. edema, & inc. fluid excretion fluid retention in lung & extremities is decreased Digitals also used to correct atrial fibrillation & atrial flutter (cardiac dysrhythmias)

Cardiac Disorders Cardiac Glycosides


Digoxin (Lanoxin) - Protein binding - low, t1/2 = 36 hrs - drug accumulation can occur - monitor SE & serum levels closely - metabolized by liver & excreted by kidneys kidney dysfunction can affect excretion of dig. - Do not confuse digoxin & digitoxin - digitoxin = highly protein bound w/ a long t1/2 seldom prescribed

Cardiac Disorders Digoxin (Lanoxin)


Action = inc. myocardial contraction (+ inotrophy), and slows HR (- chronotropy), therefore regulating the rate & rhythm of the heart - Therapeutic serum levels = 0.5 - 2.0 ng/ml Use = moderate/severe systolic CHF, arrythmias SE = Dig. toxicity - bradycardia (pulse < 60), anorexia, diarrhea, N&V, blurred vision, lethargy - older adults more prone to toxicity DI - Other heart meds

Cardiac Disorders Heart Failure


Other drugs =
* Vasodilators - dec. venous blood return to the heart & dec. cardiac filling, ventricular stretching & O2 demand * Angiotensin-converting enzyme (ACE) inhibitors - dilate venules & arterioles & improves renal bld flow & dec. bld fluid volume * Diruetics - first-line = reduces fluid volume

Cardiac Disorders Antianginal Drugs


Used to treat angina pectoris ( acute cardiac pain caused by inadequate bld flow resulting from plaque occlusion in the coronary arteries of the myocardium or from spasms of the coronary arteries) - described as tightness, pressure in center of chest, pain radiating down L arm - attacks may lead to an MI 3 Types of angina pectoris 1. Classic (stable) - stress or exercise 2. Unstable (preinfarction) - frequently over day, severity 3. Variant (Prinzmetal, vasospastic) - during rest

Cardiac Disorders Antianginal Drugs


Action - Inc. blood flow by inc. O2 supply, or by dec. O2 demand by the myocardium Nitrates, beta-blockers, calcium channel blockers Nitrates & calcium channel blockers effective in treating variant or vasospastic angina (not beta blockers) beta blockers effective in treating stable angina Non-pharm Rx = avoid heavy meals, smoking, extremes in weather changes, strenuous exercise, stress - Proper nutrition, moderate exercise, adequate rest & relaxation techniques

Cardiac Disorders Antianginals


Nitrates - First agents used - Nitroglycerine (NTG) - Action - acts directly on the smooth muscle of blood vessels = relaxation & dilation. - Dec. cardiac preload & afterload & reduces O2 demand - dilation of veins = less blood return to the heart - dilation of arteries = less vasoconstriction & resistance - Onset of Action - sublingual (under the tongue) & IV = 1 - 3 min. - transderm nitro patch = 30 - 60 min

Cardiac Disorders Antianginals


SE = Headaches - less frequent w/ continued use, hypotension, dizziness, weakness, faintness Beta Blockers - Block the beta receptor site Atenolol (Tenormin), Metoprolol tartrate (Lopressor), Nadolol (Corgard), Propranolol HCL (Inderal) - Action - Dec. the effects of the sympathetic nervous system by blocking release of epi. & norepi dec. HR & BP reduce the need for O2 & the pain of angina - Nonselective (beta-1 & beta-2) - Inderal, Corgard, Visken - Selective (beta -1) - Tenormin, Lopressor

Cardiac Disorders Antianginals


SE - Dec. in HR & BP - Closely monitor vital signs Calcium Channel Blockers (Calcium Blockers) - Newest Amlodipine (Norvasc), Diltiazem HCL (Cardizem), Nifedipine (Procardia, Adalat), Verapamil (Calan, Isoptin) - Action - Ca activates myocard. contraction; inc. workload of heart. Calcium blockers dec. cardiac contractility (inotropic) & the workload of the heart = dec. O2 need

Cardiac Disorders Calcium Blockers


Use - long - term Rx of angina SE - Headache, Hypotension, dizziness, flushing of the skin - Bradycardia w/ verapamil (Calan) - Hypotension esp. w/ Nifedipine (most potent) - promotes vasodilation of coronary & peripheral arteries Calcium blockers can cause changes in liver & kidney function - Check liver enzymes periodically Can be given w/ nitrates to prevent angina

Cardiac Disorders Antidysrhythmics


Cardiac dysrhythmia (arrhythmia) = any deviation from the normal rate or pattern of the heartbeat. HRs too slow (bradycardia), fast (tachycardia), or irregular Electrocardiogram (ECG) identifies the type of dysrhythmia - P wave = atrial activation - QRS complex = ventricular depolarization - T wave = ventricular repolarization - PR interval = atrioventricular conduction time - QT interval = ventricular action potential duration

Cardiac Disorders Antidysrhythmics


Atrial dysrhythmias = prevent proper filling of the ventricles & dec. CO by 1/3 Ventricular dysrhythmias = life threatening d/t ineffective filling of the ventricle = dec. or absent CO Dysrhythmias can occur - after an MI, from hypoxia (lack of O2 to body tissue), hypercapnia (inc. CO2 in the bld.), excess catecholamines (epi, norepi), or electrolyte imbalance

Cardiac Disorders Antidysrhythmic Drugs


2 major classifications of dysrhythmias
* Above bundle of HIS = supraventricular - A-flutter, a-fib., PACs * Below bundle of HIS = Ventricular - PVCs, Vent. tachycardia, Vfib.

Desired action = restoration of normal cardiac rhythm 4 Classes: 1. Fast (sodium) Channel Blockers - dec. the fast Na influx to the cardiac cells, so - dec. conduction time of cardiac tissue, dec. likelihood of ectopic foci, inc. repolarization - 3 subgroups of fast channel blockers

Cardiac Disorders Antidysrhythmics


Class 1A - Procainamide (Pronestyl, Procan), Quinidine Sulfate (Quinidex) - slows conduction & prolongs repolarization - Use = Control PVCs, vent. tachycardia - SE = Anorexia, headache, dizziness, weakness Class 1B - Lidocaine (Xylocaine), Mexiletine (Mexitil) Slows conduction & shortens repolarization - Use = Ventricular arrythmias associated w/ acute MIs - IM & IV - IV bolus then a drip started (1 - 4 mg/min.)

Cardiac Disorders Antidysrhythmics


Class 1C - Flecainide (Tambocor) - Prolongs conduction w/ little to no effect on repolarization - Use - Life-threatening vent. dysrhythmias, supraventricular tachycardia, a-fib or flutter Beta Blockers - dec. conduction velocity Prolong Repolarization - Amiodarone (Cordarone) emergency Rx of ventricular dysrhythmias. Inc. refractory perios & prolong action potential duration Calcium Channel Blockers - inc. refractory period of the AV node, dec. vent. response

Diuretics
Used for 2 main purposed: decrease hypertension (lower BP), & decrease edema (peripheral & pulmonary) in CHF and renal or liver disorders
* Other uses = Dec. cerebral edema (Mannitol), dec. intraocular eye pressure (glaucoma), dec. ascities (liver disease)

Used either singly or in combo to dec. BP & dec. edema Diuretics produce inc. urine flow (diuresis) by inhibiting Na & H2O reabsorption from the kidney tubules. Act on the kidneys in diff. locations to enhance excretion of Na (pg. 678)

Diuretics
Every 11/2 hr. the total vol. of the bodys extracellular fluid (ECF) goes through the kidneys (glomeruli) for cleansing = 1st process for urine formation - sm. particles (electrolytes, drugs, glucose & waste) filtered in the glomeruli Normally 99% of filtered Na passing through glomeruli reabsorbed. 50 - 55% Na reabsorbtion in proximal tubules, 35 - 40% in loop of Henle, 5 - 10% in distal tubules, <3% in collecting tubules Diuretics that act on tubules closest to glomerule have greatest effect in causing natriuresis (Na loss in urine) Mannitol

Diuretics
Diuretics have an antihypertensive effect by promoting Na & H2O loss by blocking Na/Cl reabsorption = a dec. in fluid vol. & a dec. of BP With fluid loss - edema should decrease. When Na is retained, H2O also retained & BP increases Many diuretics cause loss of other electrolytes (K, Mg, Cl, bicarb) 5 categories of diuretics:

Action of Diuretics on Different Segments of Renal Tubules

Diuretics
Thiazides/Thiazide-like Diuretics
Hydrochlorothiazide (Hydrodiuril, HCTZ), Metolazone (Zaroxolyn) * Action - Distal tubules of the kidney to promote Na, Cl, & H2O excretion; acts directly on arterioles, causing vasodilation & BP; preload & CO = dec. vascular fluid & dec. in BP * Use - Rx of hypertension & peripheral edema * SE - Electrolyte imbalance (hypokalemia), hyperglycemia (inc. bld sugar), hyperlipidemia (inc. bld lipid level), dizziness, headaches, N&V

Diuretics Thiazides
* CI - renal failure * DI - Digoxin - if hypokalemia occurs, the action of digoxin is enhanced & dig. toxicity can occur * Considered potassium - wasting - K supplements are frequently prescribed & serum K levels are monitored Loop Diuretics - Act on the ascending loop of Henle by inhibiting Cl transport of Na into the circulation (inhibits passive reabsorbtion of Na) - Potent & cause marked depletion of H2O & electrolytes - Effect = dose related - dose & response

Diuretics
Loop diuretics
More potent than thiazides as diuretics, but less effective as antihypertensive agents Can renal bld flow up to 40% Have a great saluretic (Na-loosing) effect & can cause rapid diuresis vascular fluid vol. dec. in CO & BP Bumetanide (Bumex), Furosemide (Lasix) - derivatives of sulfonamides Furosemide (Lasix) * Use - Rx fluid retention/overload due to CHF, renal dysfunction, cirrhosis; hypertension; pulmonary edema

Diruetics
Loop Diuretics
Lasix (cont) - used when other conservative measures fail (Na restriction & less potent diuretics) * May be given IV or PO * SE - Electrolyte imbalance ( esp. hypokalemia K < 3.5) & dehydration, orthostatic hypotension * DI - digitalis preparations - dig. toxicity can result * Nursing - Strict I & O, daily weights, vital signs, hydration status of client * Clients should be on K supplements, monitor serum K levels closely

Diuretics
Potassium-Sparing Diuretics
Weaker than thiazides & loop diuretics Action - act primarily in the collecting distal duct renal tubules to promote Na & H2O excretion & K retention Use - mild diuretics or in combo w/ antihypertensive drugs K supplements not used - serum potassium excess (hyperkalemia) results if K supplement taken w/ potassium - sparing diuretics

Diuretics
Potassium - Sparing
Spironolactone (Aldactone), Triamterene (Dyrenium) Aldactone (an aldosterone antagonist) - Aldosterone = a mineralocorticoid hormone that promotes Na retention & K excretion; Aldosterone antagonsits inhibit the Na-K pump (K retained & Na excreted) Amiloride (Midamor) - antihypertensive agent Triamterene - Rx of edema caused by CHF or cirrhosis K - sparing diuretics used alone = less effective than when combined with reducing body fluid & Na - Usually combine w/ a potassium wasting diuretic

Diuretics
Combination
Combine a potassium sparing & potassium wasting diuretic = intensifies the diuretic effect & prevents K loss
spironolactone & hydrochlorothiazide (Aldactazide) amiloride & hydrochlorothiazide (Moduretic) triamterene & hydrochlorothiazide (Dyazide, Maxide)

When diuretic combinations are used, either combined in one tablet or as separate tablets, the dose of each is usually less than the dose of any single drug SE = hyperkalemia - caution w/ clients having poor renal function; do NOT use K supplements (unless K low)

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