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(Deoxyribonucleic Acid)
Nucleotide
1.Sugar =
deoxyribose or ribose
A = T, G = C
DNA Structure
Double Helix
3 D view animation
Rosalind Franklin
Nucleotides, Hydrogen bonds, 3 vs 5 and antiparallel. what dos all that of mean to DNA structure???
DNA
1. Deoxyribose sugar 2. Double Helix 3. In nucleus
(& mitochondria)
mRNA
Ribose sugar
mRNA: Single stranded
tRNA: a Unit- looks like cloverleaf rRNA: sm &lg round units
4. Temporary
5. Uracil
6. Messenger
m = messenger mRNA
RNA types
r = ribosomal rRNA
t = transfer tRNA
DNA REPLICATION
/ / / /
WHAT is it? Copying ALL the DNA in a cell WHERE is it done? Nucleus WHY is it done? Make copies for daughter cells WHEN is it done?
S phase of interphase- right before cell division (mitosis or meiosis)
DNA Replication(animation)
1. Unwinding the double helix 2. Unzipping the DNA 3. Add in new nucleotides complimentary to each half 4. Moves in opposite directions
PROTEIN SYNTHESIS
Translation (animation)
Also called protein synthesis In ribosome in cytroplasm or ER 1.The ribosome attaches to mRNA ( 2 parts) 2.1st tRNA attaches at the P site at the start CODON. 3.Its job is to bring amino acids to drop off in order.
Translation continued
Translocation: the ribosome moves and the prroces repeats until a STOP
codon is reached.
REVIEW Cover your notes and look only at this diagram- discuss these with a partner
What is the role of the mRNA? What is the role of tRNA? What happens between 2 tRNAs sitting next to each other? What is being made? Where is this happening? What is this process called? What does DNA have to do with all this?
changes a single amino acid HOW? a. delete a whole code (3 nucleotides); b. change one nucleotide; c. insert a whole code
This can be harmless or somewhat bad or really bad (ex: sickle cell anemia)
shift the reading of the DNA so all the amino acids after that are different
B. Chromosomal Mutation= BIG change to chromosomeinvolves many genes all at once and whole sectrions of chromosomes
Chromosomal mutations
NOTE: most gene mutations are random errors occuring in the code during replication
IN THE NEWS!!
Quadruple DNA!
Seems to abnormal replication and be involved with cancer mutationsexciting new research area
REVIEW: A. Diagram a DNA molecule-see directions in notes- do without looking at notes! B. Use the word bank for the key terms to match to definitions- do alone and then check with a partner- do without looking at the notes!
Important terms
1.Code = a word in DNA language; 3 nucleotides, code for an amino acid 2.Gene = A sentence made of many
nucleotides that codes for a particular protein (the building blocks of the cell) proteins are made of long chains of amino acids arranged from a possible 20 different kinds of amino acids
Important terms
1. DNA 2. Nucleotide 3. CODE 4. Gene 5. Chromosome, 46, 23 6. Double helix 7. Codon 8. Anticodon 9. Transcription 10.Translation 11.Translocation 12.Complimentary 13.Replication
Translation
In ribosome Also called protein synthesis 1.Small part of ribosome attaches to mRNA 2.1st tRNA attaches at the P site. Large ribosome part attaches.
3. The 2nd tRNA lands in the A site. Ready to start creating a protein.
4. tRNA brings in amino acid to ribosome 5. Amino acids link together by peptide bond and protein chain is moved over to 2nd tRNA.
Translation continued
6. Translocation
7. Repeat until a STOP codon is reached 8. Releasing factor 9. The polypeptide chain goes to golgi to be modified.
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