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NAME : EVA A. PATEL ENROLLMENT NO. : 092820290016 SUBJECT : PHARMACEUTICAL TECHNOLOGY SHIVAM PHARMACY COLLEGE
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COATING PROCESS :
PRINCIPLE :
Tablet Coating is the process of a coating composition
to a moving bed of tablets with the concurrent use of heated air to facilitate evaporation of solvent . The distribution of coating is accomplished by the movement of tablets either perpendicular or vertical to the application of the coating composition .
to the drug . 3. To control release of drug from the tablet . 4. To protect the drug from gastric environment of stomach . 5. To improve pharmaceutical elegance by use of special colours .
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Coating Equipment Parameters of coating Process Facility and ancillary equipments Automation in coating process
3. Coating Compositions
TABLET PROPERTIES :
Tablets must posses proper physical characteristics .
polymeric films and before surface dries the applied coating changes from a sticky liquid to a tacky semisolid and eventually to a non-sticky dry surface . So tablets must be in constant motion during early drying phase or else agglomeration may occur . Coating surface must be wet enough to coat the entire tablet surface .
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moisture . Compatibility with other additives . Non-toxic and easy to apply . Should form resistance against cracking . No bridging should occur . Low cost .
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substances on the substrate surface . Eg. Water , ethanol , methanol , etc. PLASTICIZERS : They are of two types :
Internal Plasticizers : Modify chemical properties
of polymers External Plasticizers :These are film formers and change the flexibility , tensile strength and adhesion properties . Examples : Castor oil , Tweens , Spans , PEG .
COLORANTS : Provide colour and elegance to dosage form . Eg. Carotenoids , chlorophyll , iron oxides , etc.
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SUGAR COATING :
Sugar coating is the process of coating tablet core
with sucrose syrup and consequently evaporating the solvent of syrup with the help of hot air .
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Sealing tablet core- application of a water impermeable polymer such as Shellac, cellulose acetate phthalate and polyvinyl acetate phthalate, which protects the core from moisture, increasing its shelf life. Sub coating -by adding bulking agents such as calcium carbonate or talc in combination with sucrose solution.
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Smoothing process -remove rough layers formed in step 2 with the application of sucrose syrup.
Colouring - for aesthetic purposes often titanium based pigments are included. Polishing - effectively polished to give characteristic shine, commonly using beeswax, carnauba wax. Printing -indelible ink for characterisation.
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4.
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FILM COATING :
It is a single step process of coating tablet core with polymeric film . The solution is sprayed onto a rotating tablet bed followed by drying,
which facilitates the removal of the solvent leaving behind the deposition of thin film of coating materials around each tablet.
The vast majority of film coated tablets are produced by a process
which involves spraying of the coating material on to a bed of tablets. Accela Cota is one example of equipment used for film coating.
The thickness of such a coating is usually between 20 and 100 m.
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COMPRESSION COATING :
This method uses compression to form a coat on the surface of
a preformed tablet .
It is mainly used to incorporate two or more chemically
incompatible drugs in a single tablet by placing one or more ingredient in the core and other in the coating material .
It is also used for modified release tablets as the coating is done
with granules .
ADVANTAGES :
Single step process Less time consumed
DISADVANTAGES :
Highly expensive Organic solvent is used so harmful to environment.
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placed angularly on a stand rotated on its horizontal axis by motor . Heat is directed in the pan on the tablet bed surface and is exhausted by means of ducts .
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PERFORATED PANS :
Hi-coater system
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PERFORATED PANS :
Dria coater pan
Glatt coater
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sprayed on and dried . 3 types : Top spray coating Bottom spray coating Tangential coating
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SPECIAL COATINGS :
Electrostatic coating
Electrostatic coating is a manufacturing process that employs charged particles to more efficiently coat a tablet. Dip coating Dip coating is a popular way of creating thin films for research purposes. Uniform films can be applied onto flat or cylindrical substrates.
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SPECIAL COATINGS :
Vacuum film coating
Vacuum coating is a mechanized process for applying coatings to lengths of materials. The product to be coated is motivated or conveyed in a lengthwise fashion at a constant speed, and these speeds can be as high as 500 feet per minute.
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COATING DEFECTS :
PICKING & STICKING This is when the coating removes a piece of the tablet from the core. It is caused by over wetting the tablet or by poor tablet quality BRIDGING This occurs when the coating fills in the lettering or logo on the tablet and is typically caused by improper application of the solution, poor design of tablet embossing, high viscosity, high %age of solids in the solution etc. CAPPING This is when the tablet separates in laminar fashion. This occurs due to improper tablet compression
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COATING DEFECTS :
EROSION This can be the result of soft tablets, an over wetted tablet surface, inadequate drying or lack of tablet surface strength TWINNING 2 tablets stick together. Common problem with capsules. Reduce spray rate or increase the pan speed. PEELING & FROSTING The coating peels away from the tablet surface in a sheet. This indicates the coating solution didnt lock into the tablet surface. Due to over wetting, defect in coating solution or high moisture content in the tablet core.
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REFERENCE :
Remington, The science and practice of pharmacy Volume 1: 21st edition(2009);932-37. Lachman L., Lieberman, H. A., Joseph L. K. The Theory and Practice of Industrial Pharmacy; Varghese Publishing House; Mumbai; Third Edition;297-321. Aultons, The design and manufacture of Medicines, Third edition(2007);497-514 http://www.authorstream.com/Presentation/munna4041968681-coating/ http://www.authorstream.com/Presentation/amitmgupta3 1-84091-tablet-coating-ppt-pharmaceutics-amit-guptaleture-science-technology-powerpoint/
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