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ASCUS PAP Recurrent ASCUS PAP ASC-H PAP AGC (AGUS) LSIL PAP HSIL PAP Guidelines for treatment of abnormal histology Biopsy Confirmed CIN 2 or 3 Colposcopy in Pregnancy Immunosuppressed Patients
ASCUS PAP Automatically sent for HPV DNA testing Index Next Slide
Positive (+)
Negative (-)
Colpo
(+)
(-)
Routine Screening
Colpo
Normal
For postmenopausal women (even on HRT) with ASCUS can consider treating with estrogen vaginal cream for two weeks, then discontinuing one week prior to repeat pap smear. If negative, repeat pap again after estrogen treatment in 4-6 months. If negative again can resume routine screening. If>=ASC must send for colposcopy.
Index
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ASC-H Pap
Index Next Slide
Colposcopy with ECC for all patients.
No lesion identified
AGC (AGUS)
Index
AGUS pap
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Colposcopy with ECC and EMB for all patients.
No invasive disease
Neoplasia
HSIL or AGC
LSIL PAP
Index
Colposcopy with ECC for all patients
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No CIN/CA
HPV testing at 12 Months >=ASC or HPV+ Negative
CIN/CA
Repeat Colpo
Routine Screening
HSIL
Index
Satisfactory Colpo
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CIN 2, 3 On biopsy
No lesion seen
No change
Change Dx
Per Guidelines
Per Guidelines
Per Guidelines
.
HPV positive
No CIN
CIN 2,3
Per Guidelines Annual Screening Consider treating patients With persistent LSIL At 12 months
Index
Satisfactory Colpo
Excision or ablation of T-zone (ablation for Small, <2 quadrant Lesions only)
(+)
(-)
Exceptions: adolescents with CIN 2 with satisfactory colposcopy who are reliable can be followed for 12 months for spontaneous clearance of disease. Recommend q 6 months colposcopy x2 with HPV typing at 12 months. Patients with persistent CIN should be treated. Patients with normal colposcopy but positive HPV should be followed closely until resolution is documented.
Colposcopy
Repeat colposcopy every three months in pregnancy, and again 8 weeks after delivery. Treatment of lesion should be based on post partum colposcopy and histology. If colposcopic impression or pathology during pregnancy suggests CIS, patient needs to be referred to an OB/GYN for possible excisional procedure while pregnant. Cervical biopsies are considered safe in pregnancy, although there is an increased risk of bleeding. ECC IS CONTRAINDICATED.
Immunosuppressed Patients
(HIV, immunosuppressive therapy including chronic steroid use) Index
Treatment of low grade lesions in immunosuppressed women results in poor clearance rates and no observable decrease in the rate of progression to high grade disease. The literature therefore supports observational management of immunosuppressed women with low grade disease.
Treatment of CIN 2, 3 results in high rates of recurrence for CIN , but does appear to be effective in preventing progression to invasive cancer. The addition of 5-FU after treatment of CIN 2,3 halved the reoccurrence rate in one study. In HIV positive women, the administration of highly active antiretroviral therapy (HAART) at the time of treatment may help to clear disease. Consider OB/GYN and ID consultation prior to treating this group of women.