Académique Documents
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Nail Anatomy
Nail plate actual nail made of tightly packed onychocytes; DIPJ in close proximity. Proximal Nail Fold Cuticle Nail Matrix Epithelium beneath nail plate; longitudinal grooves (melanoma, splinter hemorrhage); splinter hemorrhage-endocard trichinosis, trauma, PS, vasculitis) Hyponychium epithelum on volar surface of digit Lunula visible portion of distal matrix Lateral digital artery
Proximal portion of nail matrix gives rise to dorsal nail plate Distal portion of nail matrix produces the ventral nail plate Proximal matrix >> pitting(paraker), onychorrhexis, beaus lines Mid-matrix >> leukonychia Distal Matrix .. Onycholysis, thinned nail plate, erythema of the lunula Melanocytes more numerous in distal nail matrix than proximal (melanonychia)
Nail Embryology
Matrix
appears at 10 weeks as a wedge of basal like cells (matrix primordium) Earliest nail plate at 14 weeks Full nail at 17 weeks
the fingertips and toes Fine touch/increases tactile sensitivity Essential for picking up small objects Toenails contribute to foot biomechanics
Fingernails 3mm/month; replacement = 6 months Toenails 1mm/month; replacement = 12 18 months Faster Growth Rates Psoriasis, males, youth, onycholysis, summer, periungual inflammation, onychophagia, day, premenstrual, pregnancy, hyperthyroids handedness. Slower growth rates: thumb and 5th finger, viral disease/fever, chemo, immobilization, poor nutrition, yellow nail syndrome
Acquired Melanonychia
Acquired Melanonychia
Case Presentation
80 year old woman presented with longitudinal melanonychia, or longitudinal dark pigmentation of the nails Noticed the pigmentation after a year since the start of hydroxyurea treatment for essential thrombocythemia
had no other side effects, no other hyperpigmentation, and was not taking any other medications that would have caused nail changes. So how did this happen?
Hydroxyurea Therapy
Hydroxyurea is used to treat a certain type of chronic myelogenous leukemia It is also used to treat ovarian cancer, melanoma, and certain types of head and neck cancer (including cancer of the mouth, cheek, tongue, throat, tonsils, and sinuses). Hydroxyurea is also used to reduce the frequency of painful crises and reduce the need for blood transfusions in patients with sickle cell anemia Hydroxyurea treats cancer by slowing or stopping the growth of cancer cells in your body. Hydroxyurea treats sickle cell anemia by helping to prevent formation of sickle-shaped red blood cells.
Well...
Melanonychia is a rare SIDE EFFECT of hydroxyurea therapy The differential diagnosis includes:
Subungal melanoma Pigmented squamous cell carcinoma Subungal hematoma Nevus Hyperpigmentation due to other drugs
can cause a severe decrease in the number of blood cells in your bone marrow However, the mechanism of hydroxyurea induced melanonychia is UNKNOWN. Potential causes include:
Toxicity affecting the nail bed or nail matrix Focal stimulation of nail matrix melanocytes Photosensitization
What is Melanonychia
Melanin within the nail plate is usually produced by nail matrix melanocytes Active melanocytes transfer melanin-rich melanosomes by the way of dendrites to differentiating nail matrixderive onychocytes This can lead to a longitudinal streak along the nail plate
Nail matrix melanocytic activation Nail matrix melanocytic hyperplasia Nail invasion by melanin producing pathogens
Other nail pathogens can cause NON MELANIC brown to black nail pigmentation
NAIL MATRIX SHAVE BIOPSY!!!! Nail plate clipping can be sent for histological evaluation or histological analysis Examination of affected nails w/a dermatoscope Hutchinson sign a sign of subungal melanoma, however it is not the best predictor of disease!
Treatment of Melanonychia
Depends
on the etiology
Discontinue medication/therapy! Multivitamins Time Last two are if problem is not melanonychia, but rather an outcome of another etiology.
See
a Dermatologist
Green Nails
Introduction
A
53 year old intensive care nurse being treated with efalizumab for psoriasis involving her arms, legs and nails. After a few weeks of treatment the patient started to develop a strange discoloration of both thumbnails.
Oh my
Diagnosis
After
careful bacteriologic examination of the nail scrapings it was determined that the strange discoloration was caused by Pseudomonas aeruginosa and Klebsiella pneumoniae. Both organisms were shown to be sensitive to fluoroquinolone
Pseudomonas aeruginosa
A
Gram negative, aerobic, coccobacillum bacterium Commonly found in moist dwellings P. aeruginosa secretes a variety of pigments, including pyocynanin, pyoverdin, and pyorubin.
Pathomechanics of Infection
Psoriasis-induced
onycholysis Patient may have acquired when gardening or at work in the hospital. Frequent hand washing may have created a moist environment for infection.
Treatment
2
Others..
Mainly due to obvious cosmetic procedures, topical or oral drugs, or common diseases. None is of particular significance in itself, its presence sometimes aiding in the diagnosis of disease or pointing towards overdose of drugs.
Underlying onycholysis and subungal hyperkeratosis Modification of matrix and or nail bed
Causes:
Apparent leukonychia
Diffuse distal and lateral subungual onychomycosis, superficial white onychomycosis, keratin granulation, etc.
True leukonychia
Alkaline metabolic disease, alopecia areata, Gout, Hodgkins disease, Occupational, Sickle cell, Tumors, etc.
Yellow Nail
Tetracycle fluorsecent lunula Penicillamine Clioquinole (topical) Mepacrine (nail bed) Jaundice
Blue/Blue-Grey Nail
Antimalarials
Argyria
Bleomycin Congenital
Red/Purple
Angioma Cirsoid aneurysm tumour Glomus tumor Congestive cardiac failure (lunula) Enchondroma Heparin Lichen planus Linear red line
Citations
Baran, R., Julian Barth, and R. P. R. Dawber. Nail Disorders: Common Presenting Signs, Differential Diagnosis, and Treatment. New York: Churchill Livingstone, 1991. Print. Stern, Dana. "Nail Disorders." Dermatology Lecture. The New York College of Podiatric Medicine, New York. 07 Feb. 2013. Lecture. Ranta, Dana MD and Bonmati, Caroline MD. Acquired Melanonychia. New England Journal of Medicine 2009; 361:1188 September 17, 2009. Hengge, Ulrich R. MD and Bardeli, Virginia MD; Green Nails New England Journal of Medicine March 12, 2009