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CEREBRAL PALSY
Chronic disability of central nervous system origin characterised by aberrant control of movement of posture, appearing early in life and not the result of progressive neurological disease.
Spastic:
Hemiplegia:
Diplegia:
Quadriplegia:
Rigidity:
Dyskinesia: Involuntary movements and changes in muscle tone. Damage to basal ganglia and extraphyomides pathways.
Athetosis: Slow writhing movements of limbs. Extension and fanning of fingers and extension of wrist. Quick jerky movements of trunk and prox, limb muscles.
Chorea:
Paraplegia:
Double Hemiplegia:
Monoplegia:
Singletons
1500gr or less
Dysequilibrium Syndrome
1.
Difficulty in maintaining an upright position and in experiencing the position of the body in space.
Autosomal recessive.
2.
CEREBRAL PALSY
1.
2. 3. 4. 5.
6.
7.
Hemiplegia. Double Hemiplegia. Diplegia (hypotonic, dystonic, spasticity, ataxic). Ataxia. Dysequilibrium Syndrome. Dyskinetic. Mixed.
Of 229 children cerebral palsy at 1 year of age, more than were free of motor handicap at 7 years.
Birth History
a) b) c) d) e) Prematurity. Seizures. Low apgars. Intracranial haemorrhage. Periventricular leucomalacia.
2. 3.
Altered Tone.
Persistence of primitive reflexes. Abnormal posturing.
PLACENTA
1.
Correlation of placenta infarction or thrombosis with ischaemic lesions in the brains of babies who have suffered intrauterine or early neonatal deaths.
11 / 15 placental slices from 15 patients with Cerebral Palsy contained thrombosis.
2.
c)
d)
Thrombosis in placental circulation. Coagulation abnormalities in mother and foetus Factor V Leiden Mutation which is responsible for activated protein C resist (APCR). Foetal and neonatal stroke have been reported in presence of maternal anticardiolipin antibodies. 20 / 31 children with cerebral palsy had one or more disorders of coagulation in neonatal blood spot analysis.
ANTENATAL
Maternal infection & cerebral palsy
a)
b)
Cerebral Palsy
1.
2. 3. 4. 5. 6.
Fall in incidence of Cerebral Palsy in low birth weight babies. in incidence in babies 2.5-4kg (2/3 of cases). Excess boys (C58%). in incidence of dyskinetic cerebral palsy. in lowest socio-economic groups. Maternal age and parity.
U shaped curve < 20 years - > 34 years. 4 children or >.
7.
Breach delivery.
Feeding Problems:
Failure to suck. Tongue trusting, gagging and choking. Vomiting and regurgitation.
2. 3. 4.
5.
6.
Dribbling. Constipation. Crying, screaming and sleep disturbances. Chilblains and cold injury. Growth.
3. 4. 5. 6.
Oral Medicines:
2. 3. 4.
Botulinum Toxin
1.
2.
3.
4.
Produced by bacterium clostridium Botulinum. Blocks release of Acetylcholine from cholinergic nerve terminals. Duration of effects, 3-4 months. Adverse effects: muscle weakness.
Allergic reaction rare. Autonomic Dysfunction. Occasional flu like symptoms. Antibody development.
Preventio
1.
2. 3. 4. 5.
6.
Antenatal and Neonatal care. Early detection and advice. Drugs. Immunization and screening. Genetic counselling. Health education.