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HOMEOSTASIS NORMAL
• 3Mechanisms:
1. Metabolic
2. Hormonal
3. Renal
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Metabolic 10/18/09
Hormonal
• Insulin- β cell of Langerhans favours uptake
into cell
• Glucagon,
epinephrine,glucocorticoids,GH,thyroxin-
antagonists to insulin,favours excessive
glycogenolysis and release of more glucose in
blood
• Cooperative action of both types of hormones
help maintaining the blood glucose
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10/18/09
Renal
• Rates of Glomerularfiltration and Tubular
absorption maintain blood glucose
• Kidney threshold for glucose-180 mg%, more
than this spillover in urine –glycosuria
• TMG-375 mg/min,more accurate index than
kidney threshold
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10/18/09
ABNORMAL
• HYPERGLYCEMIA
• HYPOGLYCEMIA
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10/18/09
HYPERGLYCEMIA:
DIABETES:
•
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10/18/09
GLYCOSURIA
GFR-NC,KT & TMG ↓
A.
HYPERGLYCEMIC:
• Alimentary-IFG
• Emotional-sympathetic and splanic nerve
excitation↑
• Endocrinal
• Experimental-alloxan
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10/18/09
GLYCOSURIA
• B.RENAL:
• Hereditary
• Acquired
• Threshold –( 180 mg%) ↓
• Tubular reabsorption ↓
• Experimental-phloridzine
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10/18/09
II.HYPOGLYCEMIA
DIEBETES STATUS
• MONITORING
• A.Conventional:
• Glucose-Blood (GOD-POD)
• -Urine
• Benedict reagent
• G Y O R
• 0.5% 1% 1.5% 2->2%
• GTT: 1.Lab-Oral GTT (OGTT)
• 2.Clinic-Post-prandial (meal)
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10/18/09
B. Modern investigations
1.Glycated Hb(HbA1c) (Normal 4-8%)-1%↓30% risk
(life span 120D)
2.Glycated albumin-fructosamine(life span 20D)
3.Lipid profile
GTT
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10/18/09
MANAGEMENT OF DIEBETES
• Organs involved-side effects-
complications,acute,chronic-multiple organs
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10/18/09
CLINICAL PRESENTATION IN DM
• Cardinal Symptoms:Complications
• 1.Poly-urea-Urine↑ (wt.loss)
• -dypsea-thirst-water intake ↑
• -phagia-Food intake↑
• 2.Chronic skin infection-Boils
• -Celluloitis
• -Absesses
• 3.Plaques-CVD:CHD+CAD→Myocardial infarction
• 4.Retinopathy
• 5.Nephropathy
• 6.Fatty liver
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10/18/09
• 7.Ketone bodies
• 8.altered lipid profile
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10/18/09
Differentiation of DM
Parameter Type I Type II
Features Juvenile(Puberty) Adult
Diet Under nourished Over nourished
Prevalence 10-20%% 80—90%
Genetics Weak Strong
Defect βCells β Cells-Normal
Ketosis Common Rare
Insulin ↓ No change
O.Hypogly.agent Unresponsive Unresponsive
Insulin Always required Not required