NDDU COLLEGE OF NURSING Definition An ectopic pregnancy is one in which the fertilized egg implants in tissue outside of the uterus and the placenta and fetus begin to develop there The most common site of occurrence is within a fallopian tube, however, ectopic pregnancies can occur in the ovary, the abdomen and in the lower portion of the uterus (the cervix) Put very simply, an ectopic pregnancy means "an out-of-place pregnancy Ectopic Pregnancy is a common, lifethreatening condition affecting one in 100 pregnancies As the pregnancy grows it causes pain and bleeding. If it is not treated quickly enough it can rupture and cause abdominal bleeding, which can lead to maternal cardiovascular collapse and death Ectopic Pregnancy Ectopics happen in about 0.25-1% of all pregnancies The mortality rate is about 1 per 1000 ectopics (10% of all maternal deaths)
Ectopic pregnancy rate increased almost 4 fold (from 4.5 per 1000 pregnancies to 16.8 per 1000 pregnancies since 1970)
Fatality rate from ectopic pregnancies dropped almost 90% (from 35.5 per 1000 ectopics to 3.8 per 1000 ectopics)
Most ectopic pregnancies occur in women aged 25-34 years
Over 75% of ectopics are diagnosed before 12th week of gestation
Ectopic Pregnancy The decrease in maternal morbidity is due to:
early detection of pregnancy (hCG assays) aseptic (sterile) technique antibiotics anesthetic agents availability of blood and transfusions surgical techniques (salpingectomy & salpingostomy)
Classification Tubal pregnancy (96-98%) ampullary (mid) portion of the fallopian tube (80-90%) isthmic (area closer to uterus) portion of the fallopian tube (5-10%) fimbrial (distal end away from uterus) portion of the fallopian tube (5%) cornual (within the uterine muscle) portion of the fallopian tube (1-2%) Abdominal (1-2%) primary/secondary (tubo-abdominal/abdomino-ovarian) Ovarian (0.5-1%) Cervical (less than 0.5%) Heterotopic (combination of ectopic + intrauterine pregnancy) Uncommon Ectopics Intraligamentous pregnancy (in broad ligament)
Pregnancy in a uterine diverticulum or sacculation
Angular pregnancy (inside the uterotubal attachment)
Pregnancy in a rudimentary horn of uterus
Intraural pregnancy (in myometrium)
Vaginal pregnancy
Multiple tubal pregnancy Histology & Anatomy The fallopian tubes (oviducts) are small, hollow muscular tubes each about ten cm long Inside the tube is delicate mucous membrane that forms the fimbriae In the epithelial lining of the tubes half the cells are mucus- secreting and half have cilia- tiny hair like projections which beat gently to propel these secretions towards the uterus The muscular wall of each tube becomes thicker towards the uterus, and has a natural peristaltic action which assists the movement of mucus Embryology & Physiology Risk Factors for Ectopic Pregnancy Pelvic inflammatory disease (PID) or Salpingitis 6 -10 times higher risk. Mainly invasion of gonorrhea or chlamydia from the cervix up to the uterus and tubes and infection in these tissues causes an intense inflammatory response and scar tissue adhesions in the tube and may damage the cilia of the fallopian tube
Ovulation induction or ovarian stimulation Risk Factors for Ectopic Pregnancy In vitro fertilization 2-5% of pregnancies are conected with IVF
Advancing age
Previous ectopic about 10-20% of women attempting pregnancy after one ectopic will have another
Salpingitis Isthmica Nodosa uncommon diverticulae in the proximal (isthmic) portion of the tube that enhance tubal implantation of the early developing embryo
Pelvic adhesions, pelvic tumors
Atrophic endometrium
Septate uterus
Zygote abnormalities (chromosomal abnormatity, neural tube defects, abnormal spermatozoa) Symptoms One-sided pain in abdomen (can be persistent and severe, but may not be on the same side as an ectopic pregnancy) Shoulder-tip pain (due to internal bleeding irritating the diaphragm when woman breathe in and out) Bladder or bowel problems (woman feels pain when she has her bowels open tenesmus, or when she passes water) Collapse (feeling of light-headed or faint, paleness, increasing pulse rate, sickness, diarrhoea and falling blood pressure) Pregnancy test (from urine may be positive but not always hCG blood tests to confirm) Amenorrhoea (missed or late period) Abnormal vaginal bleeding Symptoms of pregnancy Fever (unusual, occuring in 2% of pacients)
Ectopics Manifestation Emergency presentation - Suddenly, without warning a woman is very unwell, collapses and is taken to hospital in fase of haematoperitoneum and hemorrhage shock
Subacute presentation - The most common presentation is with a missed period, positive pregnancy test, some abdominal pain, and irregular vaginal bleeding
Rrisk pregnancy group - After previous ectopic, tubal surgery or assisted conception ( IVF) detection rate is high women are primary observed
Diagnosis Early diagnosis of an ectopic pregnancy is critically important There is no uniformly accepted diagnostic protocol History Physical examination (pain, adnexal mass, enlarged uterus) Transvaginal or transabdominal ultrasound Quantitative hormone tests (HCG, -hCG, progesterone) Occasionally culdocentesis (thin needle is inserted at the top of the vagina, between the uterus and the rectum, to check for blood in CD) Sometimes dilatation and curettage (exclude intrauterine pregnancy or incomplete abortion)
Diagnosis Pseudogestational sac in uterus (is seen in 10-20% of ectopics)
Adnexal mass or Tubal ring (gestational sac, yolk sac or fetal pole)
Occasionaly hemosalpinx (tubes fill with blood)
Enlargement of uterus (not appropriate for date)
Fluid in Cul De- Sac Differential Diagnosis Abortion (complete,incomplete, inevitable, missed) Threatened appendicitis Acute dysmenorrhea Placenta previa Shock (hemorrhagic, hypovolemic) Ruptured corpus luteum cyst Adnexal torsion Cornual myoma or abscess Ovarian tumor Endometrioma Cervical cancer Management Once an ectopic is diagnosed, there are several different treatments
It is not possible to take the pregnancy from the tube and put it into the womb
In all cases, the pregnancy must be terminated
Various forms of management
The appropriate surgery follow up for the patient are serial blood tests of the pregnancy hormone (-HCG)
Within a few weeks, the pregnancy hormone should not be measureable Management (cont) Expectant management - proportion of all ectopics will not progress to tubal rupture, but will regress spontaneously and be slowly absorbed Level of hCG must falling and a woman becomes clincally well. Situation needs daily hCG, TVS. If hCG increases or sonographic findings are suspicious active management Medical treatment (methotrexate,dyktinomycin, hyperosmolar glucose, potassium chloride, mifepristone) given by injection in form of systemic or local administration Laparoscopic surgery - (salpingotomy or salpingectomy). Open surgery (laparotomy) - involves a 5-8 cm incision at the top of the pubic hairline The affected tube is brought out and either salpingotomy or ectomy is performed The options are as follows: Criteria for Expectant Management Decreasing hCG titers (less than 1500 mIU/mL ) Tubal location (rather than ovarian, abdominal, cervical) No evidence of rupture or significant bleeding Ectopic mass with size less than 4 cm Highly motivated patient with strong desire to avoid both surgery and medical management Hemodynamically stable healthy woman Absence of fetal heart tones Methotrexate Treatment Anti-metabolite drug Inexpensive, easy to obtain, well tolerated Mixture containing at least 85% of folic acid antagonist "4-amino-10- methylfolic acid and 25% of Leucovorum calcium (folic acid agonist)
The initial dose regimen MTX (1 mg/kg IM ) or single IM dose of 50 mg/square meter Leukovorum (0.1 mg/kg IM )
Dont exceed 4 doses 70-95% efficiency of cases treated Methotrexate management takes 4-6 weeks for complete resolution of the ectopic pregnancy Complications of Methotrexate Bone marrow suppression Acute and chronic hepatotoxicity transient elevations in serum liver transaminases Progressive pulmonary toxicity (pneumonitis and pulmonary fibrosis) Dermatologic effects (rashes, itch, folliculitis, photosensitivity, pigment changes, rarely alopecia) Renal impairment GI side effects (stomatitis, gastritis, diarrhoea) Invasive Treatment The standard aim of care is to control the bleeding and remove the ectopic pregnancy
Prior to the late 1980's, this was accomplished by first making a large incision in the woman's abdomen and "looking" to find if there was a swollen fallopian tube containing the ectopic
With the advent of advanced laparoscopic technique, the ectopic pregnancy can be identified with only a small incision below the umbilicus (navel)
Microinvasive technique
Surgical Treatment Forms Salpingotomy: Making an incision on the tube and removing the pregnancy
Salpingectomy: Cutting the tube out
Segmental resection: Cutting out the affected portion of the tube
Fimbrial expression: "Milking" the pregnancy out the end of the tube
Usually, if the tube is not ruptured laparoscopy
Cases of rupture with significant hemorrhage into the abdomen laparotomy Complications Hemorrhage and hypovolemic shock Infection Loss of reproductive organs following surgery Infertility, sterility Urinary and/or intestinal fistulas following complicated surgery Disseminated intravascular coagulation Persistent ectopic (complication of conservative surgical treatment, incomplete removal of trofoblastic tissue) Rh disease
Emotions Changes Ectopic pregnancy can be a devastating experience (loss of baby, loss of part of fertility, recovery from surgery)
Postsurgery depression
Sudden end to pregnancy hormonal disarray
Distress and disruption of family life Prognosis The prognosis with an ectopic pregnancy is good for patients with an early diagnosis
Good when fertility is preserved (as much as possible)
Patients with a previous ectopic pregnancy should be educated regarding the potential increased risk for another ectopic pregnancy The Future Pregnancy If one of the tubes was removed, woman ovulate as before, but chances of conceiving will be reduced to about 50%
Woman can still become pregnant and have a successful pregnancy with one intact tube
Overall chances of a repeat ectopic are between 710% and depends on the type of surgery
If infertility occurs, fertility treatment techniques can still help a woman achieve pregnancy (IVF) Tubal Pregnancy Is a pregnancy that grows in the fallopian tube, not the uterus
If the pregnancy continues and the tube ruptures, there may be life-threatening intraabdominal bleeding
Even with the modern practice of medicine, the rupture of the tubal ectopic pregnancy is still one of the leading causes of gynecological deaths Tubal Pregnancy Findings Acute tubal rupture (40% of tubal pregnancies) Chronic tubal rupture (60% of tubal pregnancies) Early unruptured tubal pregnancy Tubal abortion Tubal Pregnancy at USG Ultrasound showing uterus and tubal pregnancy 2D scan Uterus outlined in red Uterine lining in green Ectopic pregnancy yellow Fluid in uterus at blue circle is called a "pseudogestational sac" Tubal Pregnancy at USG Detailed view of ectopic (thick, brightly echogenic, ringlike structure outside the uterus) Tubal pregnancy circled in red 4.5 mm fetal pole (between cursors) in green Pregnancy yolk sac in blue Tubal Pregnancy A right tubal ectopic pregnancy seen at laparoscopy The swollen right tube containing the ectopic pregnancy is on the right at E The stump of the left tube is seen at L - this woman had a previous tubal ligation Tubal Pregnancy Close view of the same ectopic After laparoscopic resection of the tube, the tubal stump is seen at S Tubal Pregnancy Right tubal ectopic pregnancy in 11 th week of gestation Same situation after rupture Tubal Pregnancy Laparoscopist must try to remove the ectopic pregnancy, preserve the fallopian tube, and early send the patient home Diagnostic LSK picture below DIAGNOSIS & TREATMENT OPERATIVE LAPAROSCOPIC SURGERY Tubal Pregnancy The first step of this technique involves making a linear slit into the fallopian tube over the ectopic with a monopolar needle tip. Tubal Pregnancy The second step involves teasing out the ectopic pregnancy intact, and then irrigating the incision to make sure it is free of any ectopic tissue LAPAROSCOPIC SALPINGECTOMY FOR ECTOPIC PREGNANCY
Laparoscopic left salpingectomy after attempted salpingostomy for a left tubal ectopic pregnancy in a 32-year-old gravida 3 para 2 Because patient wished to retain her fertility, salpingostomy was initially attempted to save the tube, but hemorrhage and retained trophoblastic tissue dictated a partial salpingectomy (removal of part of the tube) The ectopic pregnacy is visualized in the ampullary region of the left fallopian tube CASE REPORT LSC salpingectomy (cont) Salpingostomy on the anti-mesenteric border. Is perfomed to allow withdraw of the products of conception and preservation of the tube After the tube is opened, a grasper is used to remove the products of conception LSC salpingectomy (cont) Bleeding occuring after removal of the products of conception
Electrocoagulation is used to achieve hemostasis Electrocoagulation has achieved hemostasis The tube was partially removed due to the retained trophoblastic tissue LSC salpingectomy (cont) Successive electocoagulation of the mesosalpinx and subsequent sharp dissection allows partial salpingectomy The distal tube has been removed through the port LSC salpingectomy (cont) Once hemostasis is assured, the hemo- peritoneum is evacuated
A single follow up - HCG should be examine for 2-3 weeks post operation
Ovarian Pregnancy Ovary is the white structure in the middle Pregnancy is implanted on the far right side of the ovary at the "X Around the ovary are seen bleeding and clotted blood Abdominal Pregnancy Incidence of 1 in 8000 births
Mostly secondary form of abdominal pregnancy
Predominant symptom si pain with hemorrhage
Genitourinary symptoms discomfort
Immediate surgical removal of the fetus
Retain attached placenta in site and start with MTX treatment
High maternal & fetal mortality rate
Keep in Mind If the ectopic doesnt die, the thin wall of the tube will stretch and cause pain, discomfort in the lower abdomen There may be some vaginal bleeding at this time As the pregnancy grows, the tube may rupture, causing severe abdominal bleeding, pain, collapse and if not recognized death Even if woman has ectopic, first urine pregnancy test-may be negative ! Why is ectopic pregnancy so dangerous? End with Funny Thanks for your attention !