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Pharmacology

Dr. Yuan Bing-Xiang


Department of
Pharmacology,
Medical School,
Xi’an Jiaotong University,
Tel: 82657468,
Email:
ybx@mail.xjtu.edu.cn
Tool of
explore
life secret
Compounds New drug
technology
Clinic
Medicine
Medicine
ligament Pharmacology bridge

Basic
Pharmacy
estimation Medicine
Good drug Bad drug
Basis of
Therapeutics
1. General Principles
2. Peripheral Nervous Pharmacology
3. Central Nervous Pharmacology
4. Cardiovascular Pharmacology
5. Splanchnic and Blood
Pharmacology
6. Endocrine Pharmacology
7. Chemotherapeutic Pharmacology

(7 parts)
Pharmacology
PART 1
GENERAL PHARMACOLOGIC
PRINCIPLES

CHAPTER 1 Introduction of
Pharmacology
CHAPTER 2 Pharmacodynamics
CHAPTER 3 Pharmacokinetics
CHAPTER 4 Impact factor
CHAPTER 1
Introduction of Pharmacology

【 CONCEPTION 】

【 RESEARCH METHODS OF HARMACOLOGY 】


Ⅰ CONCEPTION
1.
Pharmacology
Pharmacology is the discipline
studding the interaction or relationship
between drugs and bodies including
human being, animals and pathogens
including microorganisms (bacteria,
virus) , parasites and tumor cells….
Drugs is the chemicals beneficially
altering biochemical and physiologic
states of body, applied to prevent,
2. Two areas of pharmacology

pharmacodynamics
drugs bodies
pharmacokinetics

Impact factor
•Act on human being,
different Animals
systems pathogens
(bacteria, virus ,

Pharmacodynamics
(drugs acts on
Drug body)
action effects

effects * beneficial or therapeutic action


* untoward reaction

mechanism * drug-receptors
of action * drug-ion channels
* drug-enzymes
* ……
Pharmacokinetics
(body acts on
drug) of absorption
Undergoing
 distribution
drugs in body
excretion
 biotransformation

C-T curves C
 drug blood Concentration-Time curves
 pharmacokinetic parameters from the
C-T curves
RESEARCH METHODS
OF
PHARMACOLOGY

physiology, biochemistry, pathology, clinical


medicine, … research methods

plus
pharmacological research
methods
Method of preclinic
pharmacology
(The experimental object is
animals)
( healthy animals or ill animals)
①waking (clear-headed) animals
②anesthetic animals
③normal or abnormal organs, tissues,
cells, cell substructures and molecules
④pharmacokinetics ( C-T curves )
Method of clinic pharmacology

The experimental object is human being


( healthy volunteer and patients ) .
I phase: 20-30 healthy volunteer
II phase: >100 patients
III phase: >300 patients On market
IV phase: >2000 patients
technology,
ethics