Académique Documents
Professionnel Documents
Culture Documents
g
/
L
i
f
e
t
i
m
e
266,450
64,320
(24%)
50th
(26%)
(34%)
78,456
144,405
75th 95th 99th
Concentration-Response
and Risk Characterization
Impact of biologically-based models
Threshold-like dose-response functions
Other nonlinear exposure-response models
Use of probabilistic methods
Using distributors rather than
precautionary assumptions (e.g., Monte
Carlo techniques)
Provides central tendency (most likely)
estimates
Quantification Issues
What is meaningful measure of benefits?
Lives saved (premature fatalities avoided)
Life years saved (extension of life expectancy)
Nonfatal risk reductions (# illnesses avoided)
Moral key: benefits are risk reductions
Low-level risks, spread over large population
Not a specific, identified person or set of
victims
Valuing Premature Fatalities
Avoided
Value of a Statistical Life (VSL)
Published studies of observed $ for risk
tradeoffs
Based on accidental immediate death
(occupation, traffic safety, etc.)
Latency and discounting are key issues
Not placing $ values on lives
Observed $-for-risk tradeoffs
Low-level risks over large population
Adjusted Value of Statistical Life
(VSL) Estimates
(million 1999 dollars)
4. Life years saved and VSLY $1.2 $1.5
3. Age-adjusted VSL (age,
income, latency, discounting)
$1.3 $1.9
2. SAB-endorsed (income growth,
latency, discounting)
$2.7 $2.7
Bladder
cancer
Lung
cancer
1. EPA (unadjusted VSL) $6.1 $6.1
Other Application Issues
Interpreting BCA findings for standards
Total vs. incremental BCA
System size (scale economies)
Addressing unquantified benefits
Using best estimates of risk
reductions and monetized values
In lieu of precautionary assumptions
Using probability distributions (or ranges)
rather than point estimates
Uranium: Cost per Person Exposed
above Oral RfD for Kidney Toxicity
(000s of 1998 dollars per lifetime, log scale)
$7.6
$1,860.0
$2,150.0
$4.2 $5.2 $5.2
$290.0
$198.0
Total Population
Population > Oral RfD
Baseline
80 g/L
80 g/L
40 g/L
40 g/L
30 g/L
30 g/L
20 g/L
1
10
100
1,000
10,000
Log scale
$000s
Conclusions
BCA provisions are an important step
forward for standard setting
Enable a departure from technology-
driven basis of standard setting
Offer upside potential for designing
better standards to maximize public
health protection
Conclusions (cont.)
AwwaRF project addresses key issues:
How benefits should be estimated
How BCA should be applied and
interpreted for MCL-setting
BCA is a useful tool to guide decisions
It is not a rule by which decisions should
always be made
AwwaRF project also shows how BCA
is useful for setting research priorities