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Goal
Describe the principle of X-Ray, T-Ray,
CT-scan, NMR (MRI), PET, STED
(Principle of USG)
18961901
In 1901 Wilhelm Konrad
Roentgen: the first
recipient of the Nobel Prize
for Physics
1896 his wifes hand, he
made the first X-ray photo,
and thus, made it possible
to look inside the human
body without surgical
intervention.
X-ray vs. T-ray!!
worldsfamouspho
tos.com
T-Ray
droidmill.com
2
0
1
4
S
T
E
D
2014
Functional
Alzheimer STED 2014 Noble Prize
Cognitive psychology: Thought identification, Mind
reading (higher metabolism area & light up on
scan
Normal
CT
http://www.seattlechildrens.org/medical-conditions/brain-nervous-system-mentalconditions/hydrocephalus/
Brain CT!!
Blood vessels: brightly w contrast
The bones are whiter than
the surrounding area.
(Whiter means higher
attenuation.)
Blood vessels also brightly
due to the injection of an
iodine-based contrast
agent.
Displaced Ventricles in
Brain CT
(milli rem)
Chest X-ray
0.1
10
Head CT
1.5
150
300
Abdomen CT
5.3
530
Chest CT
5.8
580
9.9
990
Screening mammography
CT colonography
(virtual colonoscopy)
Cardiac CT angiogram
3.6 - 8.8
360 - 880
6.7-13
670 - 1300
Barium enema
15
1500
Neonatal abdominal CT
20
2000
For comparison, survivors of the atomic bombings of Hiroshima and Nagasaki were
exposed to an average of 40 mSv of radiation. This dose is comparable to 2-3 extensive
CT scans, and can increase the risk of cancer.
MRI
PET
And "little f" fMRI usually refers to mapping of brain activity using
MRI.
fMRI studies are often used in planning brain surgery, since they
can help physicians monitor normal brain function as well as
any disturbed brain function (cerebral vascular, trauma, or
degenerative disease (such as Alzheimer's) on brain function.
MRI, PET and CT scans of the brains of people affected by (clockwise from
top left): Alcoholism, marijuana use, multiple sclerosis, cocaine use,
Parkinson's disease, Alzehemier's disease.
11C
Optics
Geometrical optics
Deals with those optical phenomena that
are mostly easily described with straight
lines and plane geometry.
Deals with macroscopic light
Physical optics
Quantum optics
Dealing with quantum aspects of light,
Deals with particle (light as photon)
Physical Optics
Quantum Optics
Diffraction
Interference
Photo-electric
effect
Compton effect
Reflection
Polarization
Atomic excitation
Refraction
USG Brain
Rangkaian
detectors
Several mathematic
reconstruction technique
Iteration tech.
Fourier transformation tech.
Reverse projection tech. more directly
sample
U
S
Radio frequence Generator
1985 Wthrich: Jarak antara sejumlah besar inti hidrogen dan memakai
informasi ini dengan metode matematik bedasarkan geometri jarak untuk
menghitung struktur 3D untuk molekul. Saat ini 15-20% dari ribuan
struktur protein telah ditentukan dg NMR. Yg lain dg kristalografi sinarX, beberapa dg difraksi elektron atau difraksi neutron
http://www.corbisimages.com/stock-photo/rights-managed/42-21818506/pet-scans-show-brains-response-to-musical
USG (ultrasonography)
Not an electromagnetic wave
A mechanical wave
Reflection not transmission and emission
8 10 12 14 16 18MHz
Superficial structure
Deeper structure
procoagulant
Sound
Gelombang EM dengan frekuensi < frek cah
(f cah 4-7.5 x 10 14 Hz) = 4-7,5 x 10 7 m (c=.f)
Jangkauan pendengaran manusia F audio 20-20.000
Hz (satuan frek- 1Hz=1 siklus/det) (infrasonik< 20 Hz,
ultrasonik > 20.000 Hz) Ultrasonik =/= supersonik (
v>vbunyi)
Jangkauan pendenganran orang tua < 10.000 Hz
Anjing: 50.000 Hz +, kelelawar 100.000 Hz +.
AM (Amplitudo Modulasi): 530-1600 kHz,
T=1/f
Dinding perut
Transduser
Tulang belakang
Pulsa
Gema
Gema
Scan-A:
Waktu
sebanding jarak
rambatan
Waktu
Scan-B:
Kecerahan=ke
kuatan sinyal
Doppler Effects
Dg menggunakan pergeseran
Doppler dari USG, digunakan
utk mengukur velocity dlm tbh
man, seperti aliran darah dan
detak jantung janin
wavelength
794
771
748
725
702
679
656
633
610
587
564
541
518
495
472
449
426
403
380
intensity
STED Microscopy
100
90
80
70
60
50
40
30
20
10
Nanocrystal Semiconductor
Invitrogen.com