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Mohanad AlBayati
Mohanad AbdulSattar Ali Al-Bayati, BVM&S, MS. Physiology, PhD.
Assistant Professor of Pharmacology and Toxicology
Department of Physiology and Pharmacology
College of Veterinary Medicine
University of Baghdad
Al-Ameria, Baghdad
Phone: 0964 7700766550
E. Mail: aumnmumu@covm.uobaghdad.edu.iq
aumnmumu@yahoo.com
Pharmacology
Study of preparation, properties, uses and action of drugs,
mechanisms, and adverse effects of drugs.
many subdivisions of study
a. Medicinal chemistry
i. Study of new drug synthesis
ii. Studies the relationship between chemical structure and biological effects
b. Pharmacodynamics
c. Pharmacokinetics
d. Molecular pharmacology
e. Chemotherapy
f. Toxicology
Pharmacologist
a. MD (doctor of medicine)
b. PhD ( doctor of medicine)
c. Specializes in pharmacology
Pharmacist
Drugs
Standards of drugs
Food and Drug Administrations (FDA)
i. Has legal responsibility for deciding if a drug may be distributed
or sold
ii. Strict standards for effectiveness and purity
iii. Requires extensive experimental testing in animals and humans
before it approves a new drug
Others , EPA, IEPA, WHO, FAO
References of drugs
a. Hospital Formulary
b. Pharmacopeia : USP, PB, JP, FC
- nomenclature of the drugs
- formulas types
- properties; chemical and physical
- methods of detection and analysis
- storage
- mode of action
- dose and dosage and rout of administration
- adverse effects
Veterinary Pharmacovigilance
of
disease
physiological function.
or
the
modify
action
of
Pharmacodynamics
What is a dose?
Dose is the amount of a substance administered at one
time.
Dosage is the amount per unit weight of the exposed
individual.
Key Concepts
Dosage
Response is a mathematical relationship (positive slope).
Increased dose gives increase in observable response.
Response clinical or biochemical/molecular biology? Debate
on whether molecular response is a manifestation of toxicosis.
Causal relationship.
Observable responses.
Statistical management of variability of individual
responses.
Species, genetics, age, sex confound results
http://www.dtreg.com/logistic.htm
effects level
NOAEL: No observable
adverse effects level
SNARL: Suggested no
adverse response level
LOEL: Lowest
observable effect level
TLV: Threshold limit
value
encountered are No
Observed Adverse Effect
Level (NOAEL) and Low
Observed Adverse Effect
Level (LOAEL).
They are the actual data
points from human
clinical or experimental
animal studies.
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Question
Q: What is pharmacy?
Q: what is pharmacist?
Q: What is pharmacognosy?
Q: What is Therapeutics?
Q: What is Drug or Pharmaceutics?
Q: mention the drug sources?
Q: What are the standard of drug and references?
Q: What is Pharmacopeia?
Q: What is Veterinary Pharmacovigilance
Q: what is Pharmacodynamics?
Q: What is drug receptor?
Q: Define dosage.
Q: Define dose.
Q: what is observed effect of drug?
Q: what are the following terms?
NOEL
NOAEL
SNARL
LOEL
TLV
ED
EC
LC
TDLo
TCLo
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