HLA and NK Cell In Pregnancy

By:
Hartini Sri Utami (011314653010)
Ririn Ratnasari (011314653003)

1. Agi Harliani S. 2010. Human Leucocyte-G (HLA-G)

Dan Peranannya Dalam Reproduksi. Majalah

Kesehatan Pharma Medika Vol. 2 No. 1
2. Ashley Moffett-King. 2002. Natural Killer Cells And
Pregnancy. Nature Rieviews Immunology Vol 2.
Nature Publishing group
3. E. Albert Reece, John C. Hobbins, John Wiley &
Sons. 2008. Clinical Obstetrics: The Fetus And
Mother. Oxford UK: Blackwell Publishing
4. Joan S. Hunt, Margaret g. Petroff, Remsey H.
McIntire, and Carole Ober. 2005. HLA-G And
Immune Tolerance In Pregnancy. The FASEB
Journal Vol. 19

1. Multiple
mechanisms
provide protection
2. Both the fetus and the
mother
contribute
to
development
and
maintenence
of
the
pregnant uterus
as an
immune privilage site
3. Fetal
factors
drive
changes
in
maternal
immune respons
(Hunt, et al., 2005)

Not Rejected
Normal
pregnancy

Hunt, et al.,
2005

HLA

MHC

(Human
Leucocyte
Antigen)

(Major
Histocompatibil
ity Complex)

System is the locus of

genes that encode for
proteins on the surface
of cells that are
responsible for
regulation of the immune
system in humans
Harliani, 2010

Function: Activating
immune respons
(innante and
adaptive immune)
Wikipedia, 2014

HLA
Class I
Classical HLA
class genes

HLA
A,B,C
(class 1a molecules)

Nonclassical
HLA class
genes

HLA
E,F,G
(class 1b
molecules)

Sel
somati
k

HLA
Class
II
HLA

HLA
Class
III

DP, DQ, DR

HLA
DM,
DO
Activated
subgrup immune
cells
Makrofag
Sel dendritik
Sel epitel
kelenjar timus

Harliani, 2010

Harliani, 2010

Reece, et al, 2008

HLA G
(sHLA G in amnion fluids )

HLA C

HLA E

Moffett-King, 2002

What?

Where?
When?

Type of cytotoxic lymphocyte cell

Large lymphocytes that have abundant
granule-containing cytoplasm

In pregnancy decidua (maternal)

Trofoblast invasion in decidua 1st

trimester called uNK (Uterine Natural
Killer) cell
Moffett-King, 2002

Function:
Secreate
cytokine

CSF (Colony stimulating factor), LIF (Leukaemia

inhibitory factor) for trofoblast growth and differentiation
TNF- , IFN- ,IFN-, TGF- for inhibits trofoblast growth

HOW

NK cell express receptors : NKC (Nk complex of lectinrelated genes on chromosome 12), LRC (leukocyte
receptor immunoglobulin-lectin-related genes on
chromosome 19)

Some of the
ligands for NK cell
receptors are HLA
class I
Moffett-King, 2002

Interaction

Activating
Inhibitory

Hunt, et al, 2005

1st
Trimester

45 50%

20%

10%

1,7%
0%
Hunt et al, 2005 and Reece et al,
2008

Moffett-King, 2002

Immune respons in
pregnancy that could lead to
rejection of the fetus

Reece et al, 2008

Immunoregulatory mechanisms
in pregnancy that prevent the
rejection of the fetus In normal
pregnancy

Reece et al, 2008

SUMMARY

Pregnancy Fetus
invasion in decidua

Fetus as
semiallograft
Fetus
(EVT)

HLA

Endometri
umuNK

Immunoadaptive
NORMAL
PREGNAN
CY

Fetus not rejection