Académique Documents
Professionnel Documents
Culture Documents
Introduction
Hemoglobin F (Hb F) is predominantly produced in fetal
life
Introduction
Complete automation of the HPLC method has made this
procedure available to many clinical laboratories
As a high Hb F level interferes with Hb A1cmeasurements in
some commercially available assay systems [7], Hb F levels
may also be affected by Hb A1c
The physiological changes in %Hb F during pregnancy as
determined by HPLC have not been studied extensively
490 blood
samples from
357 women
Results
Longitudinal mean %Hb F level during the 1st
trimester did not differ significantly
study of 21
fromthat determined before pregnancy
women
Crosssectional
study
Longitudinal
%Hb F level tended to increase after
study of 11
delivery (P=0.0667)
women
Results
An
analysis
of 49
women
Results
A weak but statistically significant negative
correlation between %Hb F and %Hb A1c
levels was observed
Discussion
%Hb F level was highest during the 1st
trimester of pregnancy and declined gradually
toward the 3rd trimester
%Hb F level was significantly increased during
the 1st trimester compared with those during
the 2nd and 3rd trimesters
The increase in red cells containing Hb F during
the earlier stages of pregnancy has been
suggested to be due to an increased number of
adult F cells
Discussion
Fetal red cells during the 1st trimester exclusively contain
Hb F, while adult F cells contain both Hb F and Hb A Hb
F ranging up to 25% of the total Hb in adult F cells
Hb F accounts for an approximately 10% of the total Hb
in adult F cells
Discussion
Effect of parity on the Hb F level was not seen in
this study
Conclusion
pregnancy
Thank You