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POLYGENIC INHERITANCE
Wahyuning Ramelan
Faculty of Medicine , UI
Study Program of Medicine,
UNTAN
Multifactorial inheritance
Genotype in most situation, is a single
gene
In certain/some situation, genotype is
more than one gene polygene
polygenic inhe-ritance
In most situation, the environmental factor
which influenced the genotype to give
result the phenotype, is also many factor
multifactorial inheritance
Multifactorial inheritance2
Pathophysiology of
multifactorial/polygenic inheritance
G1
E1
G4
E4
G2
E2
G5
E5
P
E3
G3
Multifactorial inheritance3
Manifestation of multifactorial/polygenic
inheritance
Normal population distribution
Congenital disorder/malformation
Acquired disease/disorder occur in childhood
and in adultlife
Normal distribution
blood pressure, dermatoglyphics (ridge count),
head circumference, height, intelligence, skin
color
Twin studies
By studying the appearance of similar
disease or disorder in the twin member
Concordant is the appearance of the
disease or disorder in both twin member.
It is believe that genetic factor plays
more role. The higher the concordant, the
more genetic factor play its role in
developing the disease/disorder.
Concordance usually is higher in MZ twin
Twin studies2
Discordant is the appearance of the
disease or disorder in only one of the
twin member. It is believe that
environmental factor plays role. The
higher the discordant, the more
environ-mental factor has its role
Usually higher discordant is found in
DZ twin
Some concordance of
multifactor
diso.
Disorder
Concordance (%)
MZ
DZ
Psoriasis
72
15
Nontraumatic epilepsy 70
6
Manic depressive disorder
67
Schizophrenia
53
15
Bronchial asthma 47
24
Type 1 Diabetes mellitus 40
4,8
Congenital hip dislocation
40
Cleft lip, w./wo. Cleft palate
38
Tuberculosis 37
15
5
8
Some concordance of
multifactor diso.
Disorder
Concordance (%)
MZ
DZ
Rheumatoid arthritis
34
15
Club foot
33
3
Osteoarthritis
32
16
Hypertension
25
7
Systemic lupus erythematosus22
Rheumatic fever 20
6
Multiple sclerosis 17.8
2
Cancer, same site 7
1