Académique Documents
Professionnel Documents
Culture Documents
(FLUOXETINE)
Presented by:
Arni Grace Gabriel
Depression
An illness that involves the body, mood,
Pathophysiology
Neurotrophic hypothesis
Thetheorythatdefectsinthephysiologyand
metabolismof amines,
especiallycatecholamines(noradrenaline/norepi
nephrineanddopamine)andanindoleamine(ser
otonin).
Neuroendocrine Factors
MOA of Fluoxetine
Pharmacokinetics
Absorption
Well absorbed from the GI tract after oral
Distribution
High affinity for plasma proteins which is
independent of plasma concentration and
is approximately 94.5% protein-bound at
plasma concentrations of 2001000 ng/mL.
The apparent Vd of fluoxetine and
norfluoxetine (active metabolite) in healthy
adults is an average of 2045 L/kg.
Metabolism
Fluoxetine and norfluoxetine are
Elimination
Owing to the relatively slow elimination of