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DNA
DNA molecule
Organic Bases
Purines
Pyrimidines
NUCLEOTIDES
The deoxyribose, the phosphate and one of the bases
Combine to form a nucleotide
PO4
adenine
deoxyribose
STRUCTURE OF DEOXYRIBONUCLEOTIDE
AND RIBONUCLEOTIDE
NUCLEOSIDE
NUCLEOTIDE
It is a component of nucleotide
ROLE OF PHOSPHODIESTER
LINKAGE
Phosphodiester
Bonds
Link
Successive Nucleotides in Nucleic
Acids
The successive nucleotides of both
DNA and RNA are covalently
linked through phosphate-group
bridges, in which the 5phosphate group of one nucleotide
unit is joined to the 3-hydroxyl
group of the next nucleotide,
creating a phosphodiester linkage .
Joined nucleotides
PO4
A molecule of
DNA is formed
by millions of
nucleotides
joined together
in a long chain
PO4
PO4
PO4
sugar-phosphate
backbone
+ bases
2-stranded DNA
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
11
Bonding 2
PO4
PO4
adenine
thymine
PO4
PO4
cytosine
guanine
PO4
PO4
PO4
PO4
CHARGAFFS RULE:
It states that DNA from any cell of all organisms should
have a 1:1 ratio of pyrimidine and purine bases and more
specifically that the amount of guanine is equal to amount
of cytosine and amount of adenine is equal to amount of
thymine
%A=%T
%G=%C
13
A DOUBLE HELIX
14
THE DOUBLE
HELIX
bases
sugar-phosphate
chain
DNA STRUCTURE
ANTIPARALLEL NATURE
The two strands of DNA are also antiparallel(run
in opposite directions) to one another.
A strand of DNA can have the direction 5'-3' or 3'5'.
One strand in the DNA molecule is 5'-3' and the
other strand is 3'-5'.
FUNCTIONS OF DNA:
It is the genetic material, therefore responsible for carrying
all the hereditary information.
It has property of replication essential for passing genetic
information from one cell to its daughters or from one
generation to next.
Crossing over produces recombination
Changes in sequence and no. of nucleotides causes
Mutation which is responsible for all variations and
formation of new species.
It controls all the metabolic reaction of cells through
RNAs and RNA directed synthesis of proteins.
COMPLEMENTARY
The two strands of DNA are complementary to
one another because of the properties of base
pairing:
A will only pair with T by two hydrogen
bonds
G will only pair with C by three hydrogen
bonds
For example: If one strand is ACGTA the
other strand is TGCAT