Streptokinase

Streptokinase:
Is a protein secreted by several
streptococci, it can bind &
activate human plasminogen to
convert to plasmin.

: Generic name
.Streptokinase

:Brand (trade) name

Kabikinase, Streptas ( names
registered medication in Saudi Arabia
.according to FDA)

: Therapeutic class
.Thrombolytic enzyme

: Pharmacologic class
. Tissue Plasminogen Activator

Pharmacology:
Converts plasminogen to the enzyme
plasmin, which aids in dissolution of
blood clots.

:Available forms
The only available form is powder.

:Administration
.
IV ( intravenous route )-1
.IC ( intracoronary route )-2
:Action
Dissolve clot that have formed in blood
.vessels

Storage/Stability:
Store unopened vials at controlled room
temperature (59 to 86F). Use
reconstituted solution immediately or
within 8 h if stored at
36 to 46F. Discard any unused

Pharmacokinetics

Metabolism:
No metabolites identified.

Elimination:
Streptokinase is cleared by the liver.
The half life is approximately 23 .

:Indications & usage

. AMI- 1
lysis of intracoronary thrombi improvement of
ventricular function, and reduction of mortality
associated with acute MI; reduction of infarct size and
.CHF associated with acute MI
.
Pulmonary Embolism-2

.DVT-3
acute, extensive thrombi of the deep veins (eg, those
involving the popliteal vessels); lysis of acute arterial
thrombi and emboli; alternative to surgical revision for
clearing totally or partially occluded arteriovenous
cannula when acceptable flow cannot be achieved.

Dosage and Administration

Acute MI (Adults):
IV infusion Administer ASAP after symptom onset
(greatest benefit when administered within 4 h, but
benefit has been reported up to 24 h). Infuse a total
dose of 1,500,000 units within 60 min.
Intracoronary infusion Administer 20,000 units by
bolus followed by 2000 units/min for 60 min (total
dose, 140,000 units).

PE , DVT, Arterial Thrombosis, or Embolism

(Adults):
IV infusion Administer ASAP after onset of thrombotic
event, preferably within 7 days. A loading dose of
250,000 units infused into a peripheral vein over 30
minutes has been found appropriate in over 90% of

:Nursing consideration

.Monitor Coagulation profile 1

checking ECG & Vital signs-2
Be aware if patient has had either recent-3
streptococcal infection or recent treatment with
.streptokinase, higher loading dose may be necessary
Check hypersensitivity reactions, give 100 unit-4
intradermal, as ordered; wheal & flare response within
.20 minutes means patient is probably allergic
.Notify doctor immediately if hypersensitivity occur-5
Keep corticosteroids and aminocaproic acid available -6
.to treat allergic reaction and bleeding

Contraindications:
1-Active internal bleeding.
2- Recent cerebrovascular accident
(within 2 months).
3- Intracranial or intraspinal surgery
4- Severe uncontrolled hypertension.

Side Effect:

1- Bleeding.
2-Allergic reaction.
3-Sever kidney disease.
4-Dameg to the blood vessels
and others.

Notify the doctor immediately if the

patient complain of any of the
following:
1-Blurred Vision.
2-Dizziness.
3-Fever.
4-Sweating.

Streptokinas
e:
Aminocaproic
acid.

Thank you