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AUTOIMUN
Dr. Safari Wahyu Jatmiko
GRAVES DISEASE
Graves' disease:
This is the most common cause of hyperthyroidism and is
PSORIASIS
11
Psoriasis
T-cell mediated inflammatory dz
Epidermal hyperproliferation 2O to
activation of immune system
Altered maturation of skin
Inflammation
Vascular changes
12
13
N
O
R
M
A
L
STRATUM
CORNEUM
STRATUM
GRANULOSUM
STRATUM
SPINOSUM
P Disorganized
S
O Neutrophil
R accumulation
I
A
S Immaturity
I
S Proliferation
STRATUM
BASALE
DERMIS
14
15
16
17
18
Rheumatoid Arthritis
The prevalence of rheumatoid arthritis in most
Caucasian populations approaches 1% among
adults 18 and over and increases with age,
approaching 2% and 5% in men and women,
respectively, by age 65
The incidence also increases with age, peaking
between the 4th and 6th decades
The annual incidence for all adults has been
estimated at 67 per 100,000
Rheumatoid Arthritis
Both prevalence and incidence are 2-3 times
greater in women than in men
African Americans and native Japanese and
Chinese have a lower prevalence than Caucasians
Several North American Native tribes have a high
prevalence
Genetic factors have an important role in the
susceptibility to rheumatoid arthritis
Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune disease in
which the normal immune response is directed
against an individual's own tissue, including the
joints, tendons, and bones, resulting in
inflammation and destruction of these tissues
The cause of rheumatoid arthritis is not known
Investigating possibilities of a foreign antigen, such as a virus
Immunology
Macrophages:
Produce cytokines
Cytokines (TNF-) cause
systemic features
Release chemokines
recruit PMNs into synovial
fluid/membrane
B cells:
Release cytokines
Plasma cells that produce
Ab
Proliferation of T cells
Activation of B cells
Initiates
proinflammatory/jointdamaging processes
TH-1 cells:
Osteoclasts:
Bone erosion
Juxta-articular & Systemic
osteoporosis
Pathophysiology
Cytokine release
Infiltration of leukocytes
Change in cell-surface adhesion molecules & cytokines
Destruction of bone & cartilage
Rheumatoid Arthritis
Description
Morning stiffness
Arthritis of 3 or more
joints
Arthritis of hand joints
Symmetric arthritis
Rheumatoid nodules
Serum rheumatoid factor
Radiographic changes
Diabetes Mellitus
Type 1 Diabetes
What is Diabetes?
Diabetes Mellitus the presence of elevated glucose levels in the blood due to
absolute or relative insufficiencies of insulin
Autoimmune destruction of the cells in the pancreas which are used to product insulin
1. Insulin administration
Type 2
Used to be seen in older patients, now disease is becoming more prevalent in children
as obesity grows among children
1. Life style change
2. Oral medications
i. Improve insulin production
ii. Regulate abnormal release of glucose by the liver
iii. Decrease insulin resistance
3. Insulin administration
Gestational diabetes
Type 1
Genetic element/mutation, susceptibility to triggers:
Viral infections
Stress
Environmental exposure - exposure to certain chemicals or drugs
Importance of Control
Complications of Diabetes
Diabetic Ketoacidosis
Fat break down accelerates and increase the production of fatty acids
Low blood sugar, too much insulin or not enough glucose to cover insulin treatment
Heal slowly
Fail to heal
Infection
Vascular diseases
Damage to arteries
Systemic Lupus
Erythematosus
Lupus
Systemic lupus
erythematosus (also called
SLE, or lupus) is an
autoimmune disease of the
body's connective tissues.
Autoimmune means that the
immune system attacks the
tissues of the body. In SLE,
the immune system primarily
attacks parts of the cell
nucleus.
Lupus = Autoimmunity
Systemic and affects connective tissue
T-cells
B-cells
Complement System
Signal Transduction
Genetic Associations
HLAs are loci on genes that code for
certain chain on the MHC complex
HLA-DR2
HLA-DR3
HLA-DQB1 Involved in mediating
production of antibodies to ds-DNA
Main Pathology
The plasma cells are producing antibodies
that are specific for self proteins, namely
ds-DNA
Overactive B-cells
Suppressed regulatory function in T-cells
Lack of T-cells
Activation of the Complement system
Overactive B-cells
Estrogen is a stimulator of B-cell activity
Lupus is much more prevalent in females of
ages 15-45
Height of Estrogen production
T-cell Malfunctions
Fc region switch
Leads to malfunction in signaling and
decreased IL-2 production
IgG Pathogen
IgG is the most pathogenic
because it forms intermediate sized
complexes that can get to the small
places and block them.
LE Cell
The LE cell is a
neutrophil that has
engulfed the antibodycoated nucleus of
another neutrophil.
LE cells may appear in
rosettes where there
are several neutrophils
vying for an individual
complement covered
protein.
UV
light
Self
Ag
External Ag
Skin cell
Genetic susceptibility
APC
T cell
T cell
IC
APC
Defective IC
clearance
B cell
A
b
Target
Symptoms
Non-specific:
Fatigue
Weight loss
Malaise = generally feeling ill
Fever
Anorexia (over time)
Arthritis
90% of patients experience arthritic symptoms
Symmetrical
Appears in hands, wrists, and knees mainly
Skin Manifestations
Malar or
Butterfly Rash
Discoid Rash
Stimulated by
UV light
Skin
manifestations
only appear in
30-40% of lupus
patients.
Normal
Glomerulonephritis
Other Manifestations
Cardiac
Central Nervous System
Hematological